Align x

Example 4

Alignment of SEQ ID NO 1 to SEQ ID NO 100 is performed using the software Align X, a component of Vector NTI Advanced 11.5.4 by Invitrogen. Several groups of sequences have at least 90%, at least 70%, or at least 50% nucleotide sequence identity as illustrated in the alignments of FIGS. 9, 10, and 11. In these alignments, only the central variable region of the aptamers is included for simplicity. Thus, oligonucleotides with at least 50%, at least 70%, or at least 90% nucleotide sequence identity to sequences selected from the group consisting of SEQ ID NO 1 to SEQ ID NO 100 are included and may be part of the current invention.

Example 16

Alignment of SEQ ID NO 1 to SEQ ID NO 400 was performed using the software Align X, a component of Vector NTI Advanced 11.5.4 by Invitrogen. Several groups of sequences have at least 90%, at least 70%, or at least 50% nucleotide sequence identity as illustrated in the alignments of FIGS. 5, 6, and 7. In these alignments, only the central variable region of the aptamers was included for simplicity. Thus, oligonucleotides with at least 50%, at least 70%, or at least 90% nucleotide sequence identity to sequences selected from the group consisting of SEQ ID NO 1 to SEQ ID NO 400 are included as part of the current invention. FIG. 5 shows the alignment of exemplary sequences with at least 90% nucleotide sequence identity that are identified during the selection process. FIG. 6 shows the alignment of exemplary sequences with at least 70% nucleotide sequence identity that are identified during the selection process. FIG. 7 shows the alignment of exemplary sequences with at least 50% nucleotide sequence identity that are identified during the selection process.