In 16 PASC patients, CE-CT was performed in our institution. In the remaining 15 PASC patients, CE-CT was performed in the other two institutions. Among the 31 PASC patients, CT was performed (a) with SOMATOM Definition (Siemens Healthcare, Germany) in 12, (b) with Optima 670 (GE Healthcare, Tokyo, Japan) in eight, (c) with Philips Brilliance 64 (Philips Healthcare, DA Best, Netherlands) in seven, and (d) with GE Lightspeed 64 VCT (GE Healthcare, United States) in four. Among the 81 PDAC patients, 63 patients underwent CE-CT in our institution (a) with Optima 670 (GE Healthcare, Tokyo, Japan) and (b) with Philips Brilliance 64 (Philips Healthcare, DA Best, Netherlands). The remaining 18 patients underwent CE-CT in the other two institutions (a) with SOMATOM Definition (Siemens Healthcare, Germany) and (b) with GE Lightspeed 64 VCT (GE Healthcare, United States). Similar protocols were adopted during the CT examinations: 120 kVp, 200–400 mAs, gantry rotation time of 0.5 s, helical pitch of 1.375, matrix of 512, and slice thickness of 1.0 mm, with a reconstruction interval of 1.0 mm. For multiphase imaging, 100–120 ml of non-ionic intravenous contrast media (Omnipaque, 350 mg I/ml, GE Healthcare) was administrated at a fixed rate of 3.0 ml/s. The scanning time delay was 40 s for the late arterial phase and 70 s for the portal venous phase.
Optima 670
Manufactured by GE Healthcare
Sourced in Japan, Netherlands
The Optima 670 is a lab equipment product from GE Healthcare. It is a general-purpose centrifuge designed for a variety of clinical and research applications. The Optima 670 features a compact and ergonomic design, with a rotor capacity of up to 6 tubes. It operates at a maximum speed of 6,000 rpm and can generate a maximum relative centrifugal force of 4,020 xg. The Optima 670 is a reliable and versatile centrifuge suitable for a wide range of laboratory workflows.
Automatically generated - may contain errors
Lab products found in correlation
Brilliance 64, by Philips (4 mentions)
Ultravist 300, by Bayer (3 mentions)
Discovery hd 750, by GE Healthcare (2 mentions)
Ge lightspeed vct 64, by GE Healthcare (1 mentions)
Omnipaque, by GE Healthcare (1 mentions)
Somatom definition, by Siemens (1 mentions)
Revolution frontier, by GE Healthcare (1 mentions)
Somatom definition flash, by GE Healthcare (1 mentions)
5 protocols using optima 670
1
Multi-institution CE-CT Imaging in PASC and PDAC
2
Multi-Phase CT Imaging of PNETs and PDAC
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CT images were obtained by different multi-detector CT (MDCT) scanners. The following CT machines were used: Philips Brilliance 64 (Philips Healthcare, DA Best, the Netherlands), Discovery HD750 (GE Healthcare, Milwaukee, Wisconsin, USA), and optima 670 (GE healthcare, Tokyo, Japan). Dynamic CT images consisting of the unenhanced, arterial, portal venous and delayed phase images were obtained. All CE-CT were with the intravenous administration of Ultravist (Ultravist 300, Bayer Schering Pharma AG, 1.2 ml/kg body weight) at a rate of 3.0 ml/s followed by 40ml saline solution through the elbow vein via a power injector. The imaging parameters were as follows: tube voltage, 120 kVp; tube current, 200–400 mAs; a helical pitch of 1.375; slice thickness, 3.0 mm; slice interval, 3.0 mm, and a reconstruction interval of 1.25 mm. Fourteen cases of PNETs and 31 cases of PDAC patients underwent a 4-phase CT examination (unenhanced, arterial, portal venous, and delayed phase). The other 4 cases of PNETs and 8 cases of PDAC patients underwent a 3-phase CT examination (unenhanced, arterial and portal venous phase). The mean imaging time delay was 30 s for the arterial phase, 60s for the portal venous phase, and 120s for the delayed phase.
3
Multidetector Spiral CT Imaging of CMFP and PDAC
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All pathologically diagnosed patients underwent multidetector spiral CT (MSCT) examinations. Unenhanced and three-phase contrast material enhanced CT examinations were performed by using the Discovery HD750 (GE Healthcare, Milwaukee, WI, USA), Philips Brilliance 64 (Philips Healthcare, DA Best, the Netherlands) and optima 670 (GE Healthcare, Tokyo, Japan). MSCT scanning was performed through the elbow vein of patients with the help of a power injector (Ulrich Medical, Berlin, Germany). A total of 80–100 mL of nonionic contrast media (Ultravist 300, Bayer Schering Pharma AG, Berlin, Germany ) with 1.2 mL/kg of body weight was administrated at a rate of 3.0 mL/s followed by 40 mL saline solution. The CT scanning parameters were as follows: tube voltage of 120 kVp; tube current of 200–400 mAs; a helical pitch of 1.375; slice thickness of 3.0 mm; slice interval of 3.0 mm; and a reconstruction interval of 1.25 mm. Nineteen cases of CMFP and 39 cases of PDAC patients underwent a 4-phase CT examination (unenhanced, arterial, portal venous, and delayed phase). The other two cases of CMFP and eight cases of PDAC patients underwent a 3-phase CT examination (unenhanced, arterial, and portal venous phase). The enhanced images were obtained at the arterial phase (30 s), the portal venous phase (60 s), and the delayed phase (120 s).
4
Diagnostic Criteria for COVID-19 Patients
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The diagnostic criteria for suspected cases are as defined in the 6th edition of the Diagnosis and Treatment Program for COVID-19 of China [6 ]. Nasopharyngeal swabs or sputum specimens were collected for running RT-PCR tests. Patients with first negative results received repeated tests after an interval of at least 1 day. All suspected cases were divided into positive and negative groups according to the results of the RT-PCR test. Patients who were negative before but positive on retests were eventually defined as positive.
All patients were prepared for CT scan examination; 33 patients were scanned on an Optima 670 CT scanner, GE, 41 patients were scanned on Revolution Frontier, GE, and 56 patients were scanned on a SOMATOM Definition Flash, Japan. Examinations followed the normal chest protocols. The overall scan time was 2 s, and the slice thickness for reconstruction was 1.25 mm. All the reports were issued after double-blind reviews by two radiologists and were resolved by a chief radiologist when opinions diverged.
This study was approved by the Ethics of Committees of the local hospital. Informed consent for this retrospective study was waived.
All patients were prepared for CT scan examination; 33 patients were scanned on an Optima 670 CT scanner, GE, 41 patients were scanned on Revolution Frontier, GE, and 56 patients were scanned on a SOMATOM Definition Flash, Japan. Examinations followed the normal chest protocols. The overall scan time was 2 s, and the slice thickness for reconstruction was 1.25 mm. All the reports were issued after double-blind reviews by two radiologists and were resolved by a chief radiologist when opinions diverged.
This study was approved by the Ethics of Committees of the local hospital. Informed consent for this retrospective study was waived.
5
Standardized Multi-Detector CT Imaging
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Multi-detector CT systems, including Philips Brilliance 64 (Philips Healthcare, DA Best, the Netherlands) and Optima 670 (GE Healthcare, Tokyo, Japan), were used for CT scanning following a standardized protocol. Three-phase examinations consisted of unenhanced, arterial, and portal phases were performed on all patients. CT scanning parameters were as follows: tube voltage, 120 kVp; current, 200–400 mAs; pitch, 1.375; rotation speed, 0.75 s; slice thickness, 3.0 mm; slice interval, 3.0 mm; and a reconstruction interval of 1.25 mm. Following unenhanced imaging, non-ionic contrast media Ultravist 300 (Bayer Schering Pharma AG, Berlin, Germany) was administrated intravenously (1.2–1.5 ml/kg) at a rate of 3.0 ml/s followed by 40 ml saline solution, using a power injector (Ulrich Medical, Ulm, Germany). Arterial and portal phase scanning were obtained at 35 and 60 s.
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