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Sas enterprise guide 8

Manufactured by SAS Institute
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SAS Enterprise Guide 8.3 is a graphical user interface (GUI) application for the SAS System. It provides a point-and-click environment for accessing and managing data, executing SAS programs, and viewing results.

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41 protocols using sas enterprise guide 8

1

Statistical Analyses Across Disciplines

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We conducted analyses using SAS Enterprise Guide 8.1 (SAS Institute, Cary, North Carolina), R version 3.6.1 (R Foundation for Statistical Computing, Vienna, Austria), and ArcMap 10.8 (ESRI, Redlands, California) software.
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2

Outcome Analysis of Patient Cohort

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Demographic characteristics and outcomes with continuous variables were compared using Student’s t-test (Satterthwaite) or Mann–Whitney U test depending on the distribution of the data. The chi-square test was used for categorical variables. Statistical significance was set at p < 0.05. Univariate analysis of the primary outcome was performed using logistic regression analysis to obtain odds ratios and 95% confidence intervals. The Kaplan–Meier curve was used to visualize the primary outcome. All statistical analyses were performed using the statistical software SAS Enterprise Guide 8.1.
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3

Evaluating Serotype-Specific Influenza Vaccine Responses

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For each patient, an overall serotype HAI geometrical mean titer (GMT) was calculated from the 3 serotype-specific HAI titers. An overall serotype of HAI GMT ≥ 40 was considered protective. For group comparisons, the GMT with 95% confidence interval (CI) was calculated for the 3 serotype-specific HAI titers and for the overall serotype of HAI GMT. Continuous data is presented as median + interquartile range (IQR), and categorical data is presented as frequencies with percentages. The nonparametric Mann–Whitney U-test was used to compare continuous variables, χ2 test for categorical variables, and the Kruskal–Wallis nonparametric test for categorical variables with more than 2 groups. Fisher’s exact test was used for categorical variables when expected counts were less than 5. The significance level was 5%. A multivariable logistic regression analysis was applied to the group of vaccinated patients to investigate variables of relevance to achieve an overall serotype HAI GMT ≥ 40. The calculations were carried out using Sas Enterprise Guide 8.1 (Cary, North Carolina, USA).
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4

Maternal Perception of Infant Behavior

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Categorical variables are presented as counts and relative frequencies. Continuous variables are presented as mean and standard deviation (SD) or 95% confidence intervals (CI) if evenly distributed and as median with interquartile range (IQR) if skewed. We analyzed the mothers’ NPI I and II total scores, score differences between NPI I and NPI II and the scores of the six sub-categories crying, feeding, spitting, elimination, sleeping and predictability. For the main outcomes (NPI I and II and NPI score difference), mean and 95% CIs were calculated. To adjust for differences in NPI I, an analysis of covariance was carried out as a sensitivity analysis using a generalized linear model.
Effect sizes were calculated according to Cohen [Cohen’s d = (M2M1)/SDpooled] in order to provide an objective estimation of the strength of effect in addition to the crude and adjusted means. The relative “risk” (= probability) of having a positive direction in the perception of the own baby compared to average babies between the two groups was calculated using an unadjusted linear model.
SAS Enterprise Guide 8.4 (SAS Institute Inc., Cary, NC, United States) was used to perform statistical analyses and produce figures.
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5

SAS Enterprise Guide Statistical Analysis

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SAS Enterprise Guide 8.4 (SAS Institute Inc., Cary, NC, USA) was used to perform statistical analyses and produce figures.
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6

Comparing Continuous and Discrete Variables

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Continuous variables are presented as median with interquartile range (IQR) if skewed and mean with confidence intervals (CI) if normally distributed. Discrete variables are presented as counts and relative frequencies. SAS Enterprise Guide 8.4 (SAS Institute Inc., Cary, NC, USA) was used to perform statistical analyses and produce figures. Effect sizes to compare mean differences (T1 − T2) between the control and intervention groups were calculated according to Cohen using pooled weighted standard deviations.
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7

Anonymized Clinical Data Collection for PICU Capacity Analysis

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Anonymized clinical data were extracted from discharge summaries. Data were entered online into a questionnaire hosted at Microsoft Office Forms 365 for institutional users by the participating centers themselves. Alternatively, anonymized discharge letters were mailed or emailed to the principal study site (Department of Pediatrics I, University Medicine Essen) and entered by local staff (LW and KH) (Figure 1). After the completion of data collection, the raw data were downloaded as a Microsoft Office Excel file and imported into SAS Enterprise Guide 8.4 for statistical analyses.
To determine the percentage of PICU capacities represented by the participating centers, we accessed the DIVI registry of intensive care beds (German Interdisciplinary Association of Intensive Care and Emergency Medicine, Deutsche interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin) and extracted the total number of PICUs, PICU beds in Germany and the number of beds provided by the participating centers in this study. Some children’s hospitals do not report pediatric and neonatal intensive care capacities separately in the DIVI registry. These capacities were ignored for the calculation of the percentage, since we assumed that this is information is missing completely at random.
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8

Lockdown Impact on Pediatric Cases

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Continuous variables are presented as median with interquartile range (IQR) and mean with 95% confidence intervals (CI). For discrete variables, absolute and relative frequencies are given. Standardized morbidity ratios (SMR) for the lockdown period were calculated, adjusting for age and sex. The years from 2017 to 2019 served as reference period to calculate the expected number of cases for 2020. The observed number of cases in 2020 was then divided by the expected number of cases. An SMR > 1 indicates an increase in cases, an SMR < 1 a decrease. We calculated exact 95% CIs if the number of observed events in the lockdown period was <15 and employed the Poisson approximation to calculate CIs in case of ≥15 events [8 (link)]. Additionally, p-values were calculated for all SMRs.
Age groups for calculation of SMRs were defined as 0–1 years, 2–5 years, 6–11 years, and 12–17 years. Three patients with diverse gender, all from the reference period, were excluded from SMR calculations since no patient with diverse gender was admitted during the observation period.
SAS Enterprise Guide 8.4 (SAS Institute Inc., Cary, NC, USA) was used to perform statistical analyses and produce figures. SISA software [9 ] was used to calculate exact and Poisson CIs for SMRs.
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9

SAS Enterprise Guide Statistical Analysis

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SAS Enterprise Guide 8.4 (SAS Institute Inc., Cary, NC, USA) was used to perform statistical analyses and produce figures.
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10

Interrater Reliability Assessment Protocol

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Systematic measurement differences between the two observers were ruled out using Bland-Altman plots (21) . Outliers in the plots were assessed for typing errors, which were corrected if applicable. Next, a second set of Bland-Altman plots was created. This time, both observers reviewed the tracings of all outliers and found the measurements to be plausible in all cases. No changes were made to the original measurements.
To assess interrater reliability, we calculated intraclass correlation coefficients for the upper and lower amplitudes using a two-way mixed model for individual ratings (22) (link). Software SAS Enterprise Guide 8.4 (SAS Institute Inc., Cary, NC, USA) was used to perform statistical analyses and produce figures.
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