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Cb17 prkdcscid j mice nod scid

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CB17-Prkdcscid/J mice (NOD/SCID) are an immunodeficient mouse strain that lacks functional B and T cells. This strain is commonly used for xenograft studies and other research applications requiring an immunocompromised animal model.

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Nod cg prkdcscid il2rgtm1wjl szj nsg, by Jackson ImmunoResearch (2 mentions)

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NOD/SCID mice (263 citations) NOD.CB17-Prkdcscid/J (53 citations) NOD.CB17-Prkdcscid/J mice (34 citations) NOD.CB17-Prkdcscid/J (NOD-SCID) mice (17 citations) CB17-Prkdcscid/J mice (10 citations) NOD.CB17-Prkdcscid/J (NOD/SCID) (8 citations) CB17 SCID mice (7 citations) NOD.CB17‐Prkdcscid (6 citations) NOD.CB17-Prkdcscid mice (4 citations) NOD.CB17-PrkdcScid (NOD/SCID) mice (3 citations)

2 protocols using cb17 prkdcscid j mice nod scid

1

Humanized Mouse Models for HIV Research

Cited 1 time
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Mice were created and monitored as previously described (7 (link), 12 (link), 13 (link)). BLT mice were generated by implanting human thymus and liver tissue under the kidney capsule of sub-lethally irradiated NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG, The Jackson Laboratory) mice. BLT mice received 3.5×105 autologous CD34+ hematopoietic stem cells. Humanized MoM were created by transplanting sub-lethally irradiated NOD.CB17-Prkdcscid/J mice (NOD/SCID, The Jackson Laboratory) with approximately 1×106 cord blood or liver-derived CD34+ hematopoietic stem cells. All animals were irradiated prior to stem cell transplantation (BLT mice: 200 rad, MoM: 250 rad). Mice were maintained in a specific pathogen-free facility by the Division of Laboratory Animal Medicine at the University of North Carolina at Chapel Hill (UNC-CH) according to protocols approved by the Institutional Animal Care and Use Committee.
Honeycutt J.B., Thayer W.O., Baker C.E., Ribeiro R.M., Lada S.M., Cao Y., Cleary R.A., Hudgens M.G., Richman D.D, & Garcia J.V. (2017). HIV persistence in tissue macrophages of humanized myeloid only mice during antiretroviral therapy. Nature medicine, 23(5), 638-643.
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2

Humanized Mouse Models for HIV Research

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
Mice were created and monitored as previously described (7 (link), 12 (link), 13 (link)). BLT mice were generated by implanting human thymus and liver tissue under the kidney capsule of sub-lethally irradiated NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG, The Jackson Laboratory) mice. BLT mice received 3.5×105 autologous CD34+ hematopoietic stem cells. Humanized MoM were created by transplanting sub-lethally irradiated NOD.CB17-Prkdcscid/J mice (NOD/SCID, The Jackson Laboratory) with approximately 1×106 cord blood or liver-derived CD34+ hematopoietic stem cells. All animals were irradiated prior to stem cell transplantation (BLT mice: 200 rad, MoM: 250 rad). Mice were maintained in a specific pathogen-free facility by the Division of Laboratory Animal Medicine at the University of North Carolina at Chapel Hill (UNC-CH) according to protocols approved by the Institutional Animal Care and Use Committee.
Honeycutt J.B., Thayer W.O., Baker C.E., Ribeiro R.M., Lada S.M., Cao Y., Cleary R.A., Hudgens M.G., Richman D.D, & Garcia J.V. (2017). HIV persistence in tissue macrophages of humanized myeloid only mice during antiretroviral therapy. Nature medicine, 23(5), 638-643.
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