Englerin a

Manufactured by Carl Roth

Sourced in Germany, United Kingdom

Englerin A is a chemical compound. It is a natural product isolated from the plant Salvia engleri. Englerin A is used in scientific research and laboratory applications.

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Lab products found in correlation

Clemizole, by Bio-Techne (1 mentions) Egta am, by Merck Group (1 mentions) Artemisinin, by Merck Group (1 mentions) Carbachol, by Merck Group (1 mentions) Riluzole hydrochloride, by Bio-Techne (1 mentions) Gsk1702934a, by Bio-Techne (1 mentions) 1 oleoyl 2 acetyl sn glycerol, by Merck Group (1 mentions) Trpc6 pam c20, by Bio-Techne (1 mentions) Norepinephrine, by Merck Group (1 mentions)

2 protocols using englerin a

Rapid Superfusion for Neuron Studies

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All chemicals were purchased from Sigma-Aldrich unless stated otherwise. For Englerin A (Roth, Germany 0.2–1 μM), TEA, clemizole (Tocris, United Kingdom), and sucrose experiments, neurons were rapidly superfused using a gravity-fed fast-flow system. For EGTA-AM pretreatment, neurons were incubated for 5 min in nominally Ca²⁺ free Ringer’s solution in the presence of 300 μ M EGTA-AM (Merck, Germany) and subsequently washed with Ca²⁺-containing Ringer’s solution before recording.

Schwarz Y., Oleinikov K., Schindeldecker B., Wyatt A., Weißgerber P., Flockerzi V., Boehm U., Freichel M, & Bruns D. (2019). TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses. PLoS Biology, 17(9), e3000445.

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Pharmacological Compounds for Research

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Artemisinin, carbachol, norepinephrine, and 1-oleoyl-2-acetyl-sn-glycerol (OAG) were purchased from Sigma-Aldrich. GSK 1702934A, TRPC6-PAM-C20 and riluzole hydrochloride were purchased from Tocris (Bristol, UK), and (−)-englerin A was purchased from Carl Roth (Karlsruhe, Germany).

Hermann C., Treder A., Näher M., Geiseler R., Gudermann T., Mederos y Schnitzler M, & Storch U. (2022). The normalized slope conductance as a tool for quantitative analysis of current-voltage relations. Biophysical Journal, 121(8), 1435-1448.

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