Micro-computed tomography was performed on eXplore Locus Scanner GE Healthcare Biosciences (Canada). The eXplore Locus Scanner uses cone beam volumetric tomography (CBVT), which allows the entire volume of the sample to be imaged in one cycle instead of scanning slice-by-slice. This method provides short image acquisition time, high image quality, and a good signal-to-noise ratio. Chicken meat phantoms (28 (link)) with implanted OxyChip-GNP, microChip-GNP, and gold and polymer-based fiducials were scanned with a 3D voxel resolution of 90 μm (0.0936 mm). All volumes were scanned with the same micro-CT scanner settings (60 kVp, 300 μA X-ray tube current, 100-msec exposure time).
Explore locus scanner
Manufactured by GE Healthcare
Sourced in Canada
The EXplore Locus Scanner is a medical imaging device designed for preclinical research. It provides high-resolution, three-dimensional imaging capabilities for small animal studies. The scanner uses advanced detector technology to capture detailed images of anatomical structures and physiological processes.
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Lab products found in correlation
4 protocols using explore locus scanner
1
Micro-CT Imaging of Chicken Meat Phantoms
2
In vivo Micro-CT Imaging of Murine Femora
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For micro-computed tomography (micro-CT) in vivo imaging, we sacrificed and then scanned each group of mice at 8 μm resolution using the eXplore Locus scanner (GE Healthcare). In the femora, scanning regions were confined to the distal metaphysis, extending proximally 1.7 mm from the proximal tip of the primary spongiosa. BMD, BMC, BVF, TMD, Tb.N., Tb.Sp., Cr.BMD and Cr.BMC were applied for performance of quantitative analysis using software provided with 2.0+ ABA Micro-view of the micro-CT system.
3
Micro-CT Imaging of Implant Integration
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Each implant in the sheep model was imaged at day zero using clinical resolution computed tomography (CT) (Discovery RT, GE Healthcare, ON, Canada) for confirmation of appropriate defect fill. Clinical CTs were not recorded for the rabbit model given the smaller implant size rendering the image resolution too low for effective analysis. Following animal sacrifice of both the rabbits and sheep, microCT imaging was performed on a General Electric Medical Systems Locus Explore Scanner at 45-micron isotropic pixel resolution using an 18 min protocol (Kv = 80, mA = 450). Image slices were reconstructed into 3D images after calibration using a hydroxyapatite (HA) phantom and subsequent image analysis was performed using MicroView (Parallax Innovations, version 2.5.1, Ilderton, Ontario, Canada).
4
Evaluating Bone Resorption around GPC Implants
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GPC implants were imaged using clinical (imaging was done on live sheep) resolution computed tomography (CT) (Discovery RT, GE Healthcare, Mississauga, ON, Canada) at Day 0 and also after six- and 12 weeks post-implantation. Moreover, higher resolution micro-CT images (General Electric Medical Systems Locus Explore Scanner, Mississauga, ON, Canada) were obtained at a 45-micron isotropic pixel resolution (Kv = 80, mA = 450). Next, the image data acquired at different angles were reconstructed into a 3D model and analyzed by MicroView (Parallax Innovations, version 2.5.1, Ilderton, ON, Canada).
Bone resorption leads to lysis of cells and appears as radiolucent lines on radiographs [50 ]. Therefore, to detect any sign of bone resorption, clinical CT and micro-CT images were investigated in order to check the existence of radiolucent lines at the implant–bone interface.
Bone resorption leads to lysis of cells and appears as radiolucent lines on radiographs [50 ]. Therefore, to detect any sign of bone resorption, clinical CT and micro-CT images were investigated in order to check the existence of radiolucent lines at the implant–bone interface.
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