The atherogenic Western diet, composed of 17% (kcal/kcal) protein, 43% carbohydrate, and 41% fat with 1.5 g/kg cholesterol, was purchased from Research Diets. Male and female mice were fed a Western diet for 12 weeks beginning at 8 weeks of age. All procedures were approved by the University of Michigan committee on the use and care of animals, conforming to the guidelines of the International Association for Assessment and Accreditation of Laboratory Animal Care.
Atherogenic western diet
Manufactured by Research Diets
Sourced in United States
The Atherogenic Western diet is a specialized lab diet formulation developed for research purposes. It is designed to induce the development of atherosclerosis and other diet-related diseases in animal models. The diet composition includes a high fat and high cholesterol content to mimic the characteristics of a typical Western-style diet.
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Lab products found in correlation
2 protocols using atherogenic western diet
1
Western Diet Induced Atherosclerosis
2
Atherosclerosis Modulation by SPAG5 Silencing
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Eight-week-old male Apoe−/− mice with C57BL/6J background and wild type C57BL/6J mice were purchased from Shanghai Model Organisms (Shanghai, China). Mice were raised under specific-pathogen-free conditions with a 12 h light-dark cycle. Apoe−/− mice were randomly divided into 3 groups (n = 6): AS group, AS + LV-sh-NC group and AS + LV-sh-SPAG5 group. Control group (n = 6): C57BL/6J mice were fed a normal diet as a control. To silence SPAG5 in vivo, Apoe−/− mice were injected with LV-sh-SPAG5 or LV-sh-NC via the tail vein. Apoe−/− mice were fed an atherogenic Western diet (Research Diets, New Jersey, USA) for 12 weeks. All animal experiments were performed following the NIH Guide for the Care and Use of Laboratory Animals and approved by the Second affiliated hospital of Nanchang University.
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