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Cd40 002928

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Cd40−/− (002928) is a genetically modified mouse strain that lacks the CD40 gene. CD40 is a costimulatory protein found on the surface of antigen-presenting cells, such as dendritic cells and B cells, and plays a crucial role in the activation of the adaptive immune response. This mouse strain can be used in research to study the functions of CD40 and its impact on immune system processes.

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Lab products found in correlation

C57bl 6j 000664, by Jackson ImmunoResearch (2 mentions) Cx3cr1creer 020940, by Jackson ImmunoResearch (2 mentions)

2 protocols using cd40 002928

1

Diverse Murine Models for Immunology Research

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University of Minnesota Institutional Animal Care and Use Committee (IACUC) approved all animal studies. 6- to 12-wk-old female and male C57BL/6J (000664), Ifngr1−/− (003288), Tnfrsf1a−/− (003242), Cd40−/− (002928), and CX3CR1CreER (020940) mice were purchased from The Jackson Laboratory and on a C57Bl/6 background. Sm1xRag1−/− mice77 (link), CCR2-CreER-GFP (C57BL/6-Ccr2em1(icre/ERT2)Peng/J) x I-AB-flox (B6.129X1-H2-Ab1tm1Koni/J), OT-II (B6.Cg-Tg(TcraTcrb)425Cbn/J) and Rag−/− (B6.Cg-Rag2tm1.1Cgn/J) were kindly provided by Dr. Marc Jenkins (University of Minnesota). CCR2creERT2 [C57BL/6NTac-Ccr2tm2982(T2A-Cre7ESR1-T2A-mKate2)] reporter mice76 (link) were kindly provided by Burkhart Becker (University of Zurich) and were crossed to R26-tdTomato reporter mice (B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J). Animals were maintained in SPF conditions at the University of Minnesota Research Animals Resources facility with free access to food and water and kept on a 12-hour light-dark cycle.
Ben-Artzi H., Zeelon E., Gorecki M, & Panet A. (1992). Double-stranded RNA-dependent RNase activity associated with human immunodeficiency virus type 1 reverse transcriptase.. Proceedings of the National Academy of Sciences of the United States of America, 89(3), 927-931.
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2

Diverse Murine Models for Immunology Research

Check if the same lab product or an alternative is used in the 5 most similar protocols
University of Minnesota Institutional Animal Care and Use Committee (IACUC) approved all animal studies. 6- to 12-wk-old female and male C57BL/6J (000664), Ifngr1−/− (003288), Tnfrsf1a−/− (003242), Cd40−/− (002928), and CX3CR1CreER (020940) mice were purchased from The Jackson Laboratory and on a C57Bl/6 background. Sm1xRag1−/− mice77 (link), CCR2-CreER-GFP (C57BL/6-Ccr2em1(icre/ERT2)Peng/J) x I-AB-flox (B6.129X1-H2-Ab1tm1Koni/J), OT-II (B6.Cg-Tg(TcraTcrb)425Cbn/J) and Rag−/− (B6.Cg-Rag2tm1.1Cgn/J) were kindly provided by Dr. Marc Jenkins (University of Minnesota). CCR2creERT2 [C57BL/6NTac-Ccr2tm2982(T2A-Cre7ESR1-T2A-mKate2)] reporter mice76 (link) were kindly provided by Burkhart Becker (University of Zurich) and were crossed to R26-tdTomato reporter mice (B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J). Animals were maintained in SPF conditions at the University of Minnesota Research Animals Resources facility with free access to food and water and kept on a 12-hour light-dark cycle.
Patterson M.T., Burrack A.L., Xu Y., Hickok G.H., Schmiechen Z.C., Becker S., Cruz-Hinojoza E., Schrank P.R., Kennedy A.E., Firulyova M.M., Miller E.A., Zaitsev K., Williams J.W, & Stromnes I.M. (2023). Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma. Cell reports, 42(7), 112732.
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