Depsipeptide

Manufactured by Selleck Chemicals

Depsipeptide is a laboratory compound commonly used in biochemical research. It is a cyclic depsipeptide, a type of molecule composed of both ester and amide bonds. The core function of Depsipeptide is to serve as a tool for investigating various biological processes and pathways in experimental settings.

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4 protocols using depsipeptide

Chemical Compounds for Cancer Research

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Sodium-butyrate and valproate were obtained from Sigma (St. Louis, MO). Vorinostat, belinostat, Depsipeptide, entinostat, ABT-737 and ABT-199 were obtained from Selleck Chemicals (Houston, TX). ABT-263 was obtained from ApexBio (USA). Synthesis of A-1331852 was as described previously (26 ).

Chueh A.C., Tse J.W., Dickinson M., Ioannidis P., Jenkins L., Togel L., Tan B., Luk I., Davalos-Salas M., Nightingale R., Thompson M.R., Williams B.R., Lessene G., Lee E., Fairlie W.D., Dhillon A.S, & Mariadason J.M. (2017). ATF3 repression of BCL-XL determines apoptotic sensitivity to HDAC inhibitors across tumour types. Clinical cancer research : an official journal of the American Association for Cancer Research, 23(18), 5573-5584.

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Romidepsin and KU60019 Treatment Protocol

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Romidepsin (FK228, Depsipeptide) and KU60019 were purchased from Selleckchem.

Scotto L., Serrano X.J., Zullo K., Kinahan C., Deng C., Sawas A., Bates S, & O’Connor O.A. (2020). ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest. Oncotarget, 11(37), 3432-3442.

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Evaluating Epigenetic Modulator Combinations

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MGCD0103, MC1568, Tubastatin A, RGFP966, and FK228 (also called Romidepsin or depsipeptide) were purchased from Selleck Chemicals (Houston, TX). Daunorubicin (DNR) and cytarabine (Ara-C) were purchased from Sigma-Aldrich (St. Louis, MO).

Zhao J., Xie C., Edwards H., Wang G., Taub J.W, & Ge Y. (2016). Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells. Oncotarget, 8(4), 6319-6329.

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Romidepsin Embryo Culture Protocol

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Romidepsin (FK228, Depsipeptide, Selleck) dissolved in dimethyl sulfoxide (DMSO, Sigma) was added to KSOM (for mice embryo) or BO-IVC medium (for cattle embryo) at a final concentration of 50 nM. In control group, equivalent amount of DMSO (0.1%) was also added for embryo culturing.

Dang Y., Li S., Zhao P., Xiao L., Wang L., Shi Y., Luo L., Wang S., Wang H., & Zhang K. (2021). The histone deacetylase activity of HDAC1/2 is required to safeguard zygotic genome activation in mice and cattle.

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