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S raclopride

Manufactured by Merck Group
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S (−)-raclopride is a laboratory chemical used in research applications. It is a dopamine D2 receptor antagonist. The core function of S (−)-raclopride is to serve as a tool for scientific investigation and analysis, without interpretation of intended use.

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Lab products found in correlation

Pimozide, by Merck Group (1 mentions) Domperidone, by Merck Group (1 mentions) Dopamine, by Merck Group (1 mentions) Quetiapine, by Merck Group (1 mentions) Benserazide hydrochloride, by Merck Group (1 mentions) Pargyline, by Merck Group (1 mentions) Quinpirole, by Thermo Fisher Scientific (1 mentions) Skf81297, by Thermo Fisher Scientific (1 mentions) 6 hydroxydopamine 6 ohda, by Merck Group (1 mentions) Desipramine, by Merck Group (1 mentions) Pramipexole dihydrochloride, by Merck Group (1 mentions)

Close spelling variants of this product

Raclopride (33 citations) S(−)-raclopride (+)-tartrate salt (6 citations) S(−)-raclopride (+)-tartrate (3 citations)

4 protocols using s raclopride

1

Dopamine Receptor Modulation Protocol

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A dopamine D2-like receptor antagonist, S (−)-raclopride (Sigma-Aldrich, St. Louis, MO), and a D2-like receptor agonist, (−)-quinpirole HCL (Research Biochemicals International, Natick, MA), were dissolved in Ringer’s solution (NaCl 140 mM, KCl 3 mM, MgCl2·6H2O 1 mM, CaCl2·2H2O 1.2 mM) for application by retrograde microdialysis. Raclopride was dissolved in saline for intraperitoneal administration.
Kishikawa Y., Kawahara Y., Ohnishi Y.N., Sotogaku N., Koeda T., Kawahara H, & Nishi A. (2022). Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity. Frontiers in Pharmacology, 13, 988178.
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2

Pharmacological Compounds for Neuroscience Research

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Janssen Pharmaceutica (Beerse, Belgium) supplied clozapine, dopamine, forskolin, JNJ‐37822681, JNJ‐39269646, haloperidol, olanzapine, paliperidone and ziprasidone. Sigma‐Aldrich supplied domperidone, dopamine, pimozide, quetiapine, S‐(+)‐raclopride, risperidone and sertindole. MolPort, (Riga, Latvia) supplied remoxipride and spiperone. Toronto Research Chemicals, Inc., (North York, Canada) supplied bromperidol and (‐)‐nemonapride.
de Witte W.E., Versfelt J.W., Kuzikov M., Rolland S., Georgi V., Gribbon P., Gul S., Huntjens D., van der Graaf P.H., Danhof M., Fernández‐Montalván A., Witt G, & de Lange E.C. (2018). In vitro and in silico analysis of the effects of D 2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations. British Journal of Pharmacology, 175(21), 4121-4136.
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3

Optimizing Neurotransmitter Modulation Experiments

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Drugs (all from Tocris, unless specified otherwise) were reconstituted and stored according to the manufacturers’ recommendations. 6-Hydroxydopamine (6-OHDA; Sigma-Aldrich) was dissolved freshly into sterile 0.9% NaCl and 0.2% ascorbic acid immediately prior to administration to minimize oxidation. Working concentration aliquots of desipramine (25 mg/kg), pargyline (Sigma-Aldrich; 5 mg/kg), S(-)raclopride (Sigma-Aldrich; 1 mg/kg), SCH23390 (Fisher Scientific; 0.2 mg/kg), nomifensine (10 mg/kg), (-)quinpirole (0.3–6 mg/kg), SKF81297 (0.3–6 mg/kg), and L-DOPA (10 mg/kg) were prepared daily in sterile physiological saline and administered intraperitoneally at minimum 10 min prior to experimentation. L-DOPA was co-administered along with the peripheral DOPA decarboxylase inhibitor benserazide hydrochloride (Sigma-Aldrich, 12 mg/kg).
Maltese M., March J.R., Bashaw A.G, & Tritsch N.X. (2021). Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum. eLife, 10, e68041.
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4

Dopamine Receptor Drugs Protocol

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(±)-7-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (7-OH-DPAT) was received from the National Institutes of Mental Health Chemical Synthesis and Drug Supply Program. Pramipexole dihydrochloride and S-(−)-Raclopride were purchased from Sigma-Aldrich (A1237; R121; St. Louis, MO). 7-OH-DPAT, pramipexole, and raclopride were dissolved in 0.9% sterile physiological saline and administered subcutaneously. SB-277011A was obtained from MEGAPharma Kft (Budapest, Hungary) and dissolved in 25% w/v hydroxypropyl-β-cyclodextrin in sterile water and administered intraperitoneally. All solutions were made fresh daily and administered in a volume of 1 ml/kg.
Fraser K.M., Haight J.L., Gardner E.L, & Flagel S.B. (2016). Examining the Role of Dopamine D2 and D3 Receptors in Pavlovian Conditioned Approach Behaviors. Behavioural brain research, 305, 87-99.
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