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Lgx818

Manufactured by Novartis
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LGX818 is a laboratory equipment product manufactured by Novartis. It is designed for precise and reliable measurement and analysis tasks in a laboratory setting. The core function of LGX818 is to facilitate accurate data collection and processing for research and testing purposes.

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Lab products found in correlation

Hygromycin stock solution, by Thermo Fisher Scientific (1 mentions) Dabrafenib, by GlaxoSmithKline (1 mentions) Doxycycline, by Merck Group (1 mentions) Vemurafenib, by Plexxikon (1 mentions) Puromycin, by Thermo Fisher Scientific (1 mentions) Trametinib, by GlaxoSmithKline (1 mentions) Plx8394, by Plexxikon (1 mentions) Plx7904, by Plexxikon (1 mentions) Ly3009120, by Active Motif (1 mentions) Lapatinib, by GlaxoSmithKline (1 mentions)

2 protocols using lgx818

1

Multi-Kinase Inhibitor Screening Protocol

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BGB283 and BGB659 were obtained from Beigene. vemurafenib, PLX7904, PLX8394 from Plexxikon. lapatinib, trametinib, dabrafenib from GlaxoSmithKline. LGX818 is from Novartis. LY3009120 purchased from Active Biochem, Doxycycline from Sigma Aldrich, Puromycin, Hygromycin stock solution from Invitrogene., other drugs from Selleckchem. Drugs were dissolved in DMSO to yield 10mM stock and stored at −20°C.
Yao Z., Torres N.M., Tao A., Gao Y., Luo L., Li Q., de Stanchina E., Abdel-Wahab O., Solit D.B., Poulikakos P, & Rosen N. (2015). BRAF mutants evade ERK dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition. Cancer cell, 28(3), 370-383.
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2

Compound Sourcing and Preparation Protocol

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Compounds were obtained from Sigma-Aldrich, Enzo Life Sciences, Selleck Chemicals, and Merck and were dissolved in DMSO at 0.1–50 mM (mainly 10 mM) and stored at –20°C. For a detailed list of compounds, see Supplemental Tables 1 and 2. Spebrutinib was obtained from Celgene, LGX818 from Novartis. ROS-targeting agents (MIS-43, SD07, SD51) were provided by A. Mokhir, Erlangen, Germany.
Dietrich S., Oleś M., Lu J., Sellner L., Anders S., Velten B., Wu B., Hüllein J., da Silva Liberio M., Walther T., Wagner L., Rabe S., Ghidelli-Disse S., Bantscheff M., Oleś A.K., Słabicki M., Mock A., Oakes C.C., Wang S., Oppermann S., Lukas M., Kim V., Sill M., Benner A., Jauch A., Sutton L.A., Young E., Rosenquist R., Liu X., Jethwa A., Lee K.S., Lewis J., Putzker K., Lutz C., Rossi D., Mokhir A., Oellerich T., Zirlik K., Herling M., Nguyen-Khac F., Plass C., Andersson E., Mustjoki S., von Kalle C., Ho A.D., Hensel M., Dürig J., Ringshausen I., Zapatka M., Huber W, & Zenz T. (2017). Drug-perturbation-based stratification of blood cancer. The Journal of Clinical Investigation, 128(1), 427-445.
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