Mpvs 300 signal conditioner

Manufactured by Millar

Sourced in United States

The MPVS-300 Signal Conditioner is a versatile device designed to condition and process various types of electrical signals. It serves as an interface between sensors or transducers and data acquisition systems, ensuring accurate and reliable signal processing.

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Lab products found in correlation

Spr 839, by Millar (5 mentions) Mylab 30cv system, by Esaote (4 mentions) Mylab 30cv ultrasound system, by Esaote (1 mentions)

6 protocols using mpvs 300 signal conditioner

Echocardiography and Invasive Hemodynamic Monitoring in Mice

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After anesthetization with 1.5% isoflurane, echocardiography was performed to evaluate the structure and function of the left ventricle with a MyLab 30CV ultrasound system (Esaote SpA, Genoa, Italy) equipped with a 10‐MHz phased array transducer as previously described.⁶ The left ventricular (LV) end systolic diameter, LV end diastolic diameter, and posterior wall thickness were recorded. Based on these data, the ejection fraction and fractional shortening were calculated.
Invasive hemodynamic monitoring was performed with an aria pressure–volume conductance system (MPVS‐300 Signal Conditioner, Millar Instruments, Houston, TX, USA). Briefly, mice were anesthetized by 2% isoflurane inhalation, and a 1.4‐French catheter transducer (SPR‐839; Millar Instruments, Houston, TX, USA) was inserted into the LV via the right carotid artery. All data were recorded and analyzed via pressure–volume analysis data analysis software (Millar, Houston, TX, United States).

Wang H.B., Yang J., Shuai W., Yang J., Liu L.B., Xu M, & Tang Q.Z. (2020). Deletion of Microfibrillar‐Associated Protein 4 Attenuates Left Ventricular Remodeling and Dysfunction in Heart Failure. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 9(17), e015307.

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Cardiac Structure and Function Assessment

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Mice subjected to 24 h of reperfusion were anesthetized by inhalation of 1.5–2% isoflurane (Fan et al., 2017 (link)). The cardiac structure and function were monitored using a MyLab 30CV system (Biosound Esaote, Inc.) equipped with a 15 MHz probe in a small animal ultrasound instrument. Parameters were obtained from more than three beats and then averaged. Left ventricular internal diameter at end-diastole (LVIDd), left ventricular internal diameter at end-systole (LVIDs) and left ventricular fractional shortening (LVFS) were tested. Hemodynamic parameters were obtained using a 1.4-French catheter-tip micromanometer catheter (SPR-839; Millar Instruments, Houston, TX, United States ), which was inserted into the left ventricle (LV) through the right carotid artery. Subsequently, pressure-volume parameters were recorded using an ARIA pressure-volume conductance system (MPVS-300 Signal Conditioner, Millar Instruments, Houston, TX, United States) coupled to a Power Lab/4SPA/D converter, and then analyzed by Lab Chart 8 software.

Zhang M., Wei L., Xie S., Xing Y., Shi W., Zeng X., Chen S., Wang S., Deng W, & Tang Q. (2021). Activation of Nrf2 by Lithospermic Acid Ameliorates Myocardial Ischemia and Reperfusion Injury by Promoting Phosphorylation of AMP-Activated Protein Kinase α (AMPKα). Frontiers in Pharmacology, 12, 794982.

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Echocardiographic and Hemodynamic Evaluations in Mice

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Echocardiography and hemodynamic evaluations were performed after the mice (n=10 per group) were anesthetized by inhalation of isoflurane at a concentration of 1.5% to 2.0%. A MyLab30CV system (Biosound Esaote) with a 15‐MHz probe was used for echocardiography. M‐mode tracings derived from the short axis of the left ventricle at the level of the papillary muscles were recorded. Percentage of ejection fraction, left ventricular (LV) end‐diastolic diameter, LV end‐systolic diameter, and LV wall thickness were obtained.
For hemodynamic analysis, cardiac catheterization was conducted using a catheter conductor. Under the condition of pressure control, the catheter was inserted into the LV cavity via the right carotid artery. An Aria pressure‐volume conductance system (MPVS‐300 Signal Conditioner; Millar Instruments) coupled with a PowerLab/4SP A/D converter were used to recorded pressure signals and decreased rate of pressure increase.

Xu W., Zhang L., Zhang Y., Zhang K., Wu Y, & Jin D. (2019). TRAF1 Exacerbates Myocardial Ischemia Reperfusion Injury via ASK1–JNK/p38 Signaling. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 8(21), e012575.

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Echocardiographic and Hemodynamic Evaluation in Mice

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Mice were anesthetized by inhalation of 1.5-2% isoflurane. Echocardiography was performed to evaluate the structure and function of the left ventricle using a MyLab 30CV system (Biosound Esaote, Inc.) equipped with a 15-MHz probe. To measure the LV end-diastolic dimension (LVEDD), and LV fractional shortening (FS), M-mode tracings derived from the short axis of the left ventricle at the level of the papillary muscles were recorded; parameters were obtained from at least three beats and averaged. For the haemodynamic analysis, a 1.4-French catheter-tip micromanometer catheter (SPR-839; Millar Instruments, Houston, TX, USA) was inserted into the left ventricle via the right carotid artery to obtain invasive haemodynamic measurements. An aria pressure volume conductance system (MPVS-300 Signal Conditioner, Millar Instruments, Houston, TX, USA) coupled with a PowerLab/4SP A/D converter was used to continuously record the heart rates, pressure, and volume signals.

Guo Z., Tuo H., Tang N., Liu F.Y., Ma S.Q., An P., Yang D., Wang M.Y., Fan D., Yang Z, & Tang Q.Z. (2022). Neuraminidase 1 deficiency attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in diabetic cardiomyopathy mice. International Journal of Biological Sciences, 18(2), 826-840.

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Invasive Cardiac Hemodynamic Measurements

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A 1.4-French catheter tip micromanometer catheter (SPR-839; Millar Instruments, Houston, TX, USA) was used to obtain hemodynamic parameters, which was inserted into the left ventricle (LV) through the right carotid artery, as previously described²⁵ . Subsequently, ARIA pressure-volume (PV) conductance system (MPVS-300 signal conditioner, Millar Instruments, Houston, TX, USA) coupled with Power Lab/4SPA/D converter was used to measure PV parameters and display PV curve. All hemodynamic parameters were analyzed by the laboratory chart 8.0.

Xie S., Xing Y., Shi W., Zhang M., Chen M., Fang W., Liu S., Zhang T., Zeng X., Chen S., Wang S., Deng W, & Tang Q. (2022). Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia–reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination. Acta Pharmaceutica Sinica. B, 12(11), 4138-4153.

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Echocardiographic and Hemodynamic Assessment in Mice

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Mice were anesthetized by inhalation of 1.5-2% isoflurane. Echocardiography was performed to evaluate the structure and function of the left ventricle using a MyLab 30CV system (Biosound Esaote, Inc.) equipped with a 15-MHz probe. To measure the LV end-systolic diameter (LVESD), LV end-diastolic dimension (LVEDD), and LV fractional shortening (FS), M-mode tracings derived from the short axis of the left ventricle at the level of the papillary muscles were recorded; parameters were obtained from at least three beats and averaged. For the haemodynamic analysis, a 1.4-French catheter-tip micromanometer catheter (SPR-839; Millar Instruments, Houston, TX, USA) was inserted into the left ventricle via the right carotid artery to obtain invasive haemodynamic measurements. An aria pressure-volume conductance system (MPVS-300 Signal Conditioner, Millar Instruments, Houston, TX, USA) coupled with a PowerLab/4SP A/D converter was used to continuously record the heart rates, pressure, and volume signals.

Fan D., Yang Z., Liu F.Y., Jin Y.G., Zhang N., Ni J., Yuan Y., Liao H.H., Wu Q.Q., Xu M., Deng W, & Tang Q.Z. (2017). Sesamin Protects Against Cardiac Remodeling Via Sirt3/ROS Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 44(6).

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