Patients were imaged on either a Biograph 6 TruePoint PET/CT or a Biograph 64 mCT Flow (Siemens Medical Solutions USA, Inc.). Each subject was placed on the imaging table and injected with 10 mCi of 18F-Florbetapir 10–15 s after the start of listmode data acquisition. Image data were acquired at a single-bed position with the patient heart in the center of the field of view. PET data were acquired for 30 min based on findings from previous work (22 ). A low-dose CT (120 kVp, with variable mAs) was acquired for rough anatomical localization and attenuation and scatter correction. CT data were reconstructed using a 512 × 512 image matrix with 1.37 mm isotropic voxels and 5 mm slice thickness.
PET data were histogrammed into 35 frames for dynamic analysis (10 frames of 10 s each, 10 frames of 30 s each, 10 frames of 60 s each, 3 frames of 255 s each) as well as into single static sinograms for reconstruction. PET data were reconstructed using OSEM iterative reconstruction algorithms to reconstruct a 200 × 200 image matrix with 2.67 mm isotropic voxel and a 2 mm slice thickness. All PET data were reconstructed with point spread function resolution recovery (HD•PET, Siemens Medical Solutions USA, Inc.) applied.
A complete outline of the clinical protocol is provided in the Section3 .
PET data were histogrammed into 35 frames for dynamic analysis (10 frames of 10 s each, 10 frames of 30 s each, 10 frames of 60 s each, 3 frames of 255 s each) as well as into single static sinograms for reconstruction. PET data were reconstructed using OSEM iterative reconstruction algorithms to reconstruct a 200 × 200 image matrix with 2.67 mm isotropic voxel and a 2 mm slice thickness. All PET data were reconstructed with point spread function resolution recovery (HD•PET, Siemens Medical Solutions USA, Inc.) applied.
A complete outline of the clinical protocol is provided in the Section