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Mevastatin

Manufactured by MedChemExpress
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Mevastatin is a laboratory product used for research purposes. It is an inhibitor of HMG-CoA reductase, a key enzyme involved in the biosynthesis of cholesterol. Mevastatin can be utilized in experimental studies to investigate its effects on various biological and biochemical processes.

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Lab products found in correlation

Fluvastatin, by MedChemExpress (1 mentions) Lovastatin, by MedChemExpress (1 mentions) Pravastatin, by MedChemExpress (1 mentions) Hg 9 91 01, by MedChemExpress (1 mentions) Ly294002, by MedChemExpress (1 mentions)

2 protocols using mevastatin

1

Recombinant Protein Expression in E. coli

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Escherichia coli DH5α was used as the plasmid construction host, E. coli BL21 (DE3) was used as the protein expression host and the biosensor construction platform. Luria-Bertani (LB) medium (1% NaCl, 0.5% yeast extract, and 1% tryptone) was used for E. coli cultivation. When needed, antibiotics were added at required concentration. Simvastatin (ps) was purchased from Sigma-Aldrich, commercial simvastatin containing drug (cm) was purchased from a local pharmacy, lovastatin, mevastatin, pravastatin, and fluvastatin were purchased from MedChem Express.
Li H., Wang Q., Zhao R., Wang Y., Xun L, & Liu H. (2020). Construction of Escherichia coli Whole-Cell Biosensors for Statin Efficacy and Production Test. Frontiers in Cell and Developmental Biology, 8, 404.
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2

Pharmacological Inhibition of Key Pathways

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The primary antibodies used in this study and their working concentration were listed in Supplementary Table S1. The PI3K inhibitor LY294002 (Cat. no. HY-10108), SIK inhibitor HG-9-91-01 (Cat. no. HY-15776), FASN inhibitor C75 (Cat. no. HY-12364) and HMGCR inhibitor Mevastatin (Cat. no. HY-17408) were purchased from MedChemExpress (New Jersey, USA).
Zhao J., Zhang X., Gao T., Wang S., Hou Y., Yuan P., Yang Y., Yang T., Xing J., Li J, & Liu S. (2020). SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway. Cell Death & Disease, 11(1), 25.
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