Bio console 560

Manufactured by Medtronic

Sourced in Germany

The Bio-Console 560 is a laboratory equipment product designed for various biomedical applications. It serves as a general-purpose console that provides power, control, and monitoring functions for connected instruments and devices. The core function of the Bio-Console 560 is to enable the operation and integration of various laboratory equipment within a research or clinical setting.

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Lab products found in correlation

Affinity fusion, by Medtronic (2 mentions) Affinity nttm, by Medtronic (2 mentions) Cardiohelp system, by Getinge (2 mentions) Heparin, by Merck Group (1 mentions) Polystat, by Cole-Parmer (1 mentions) Sodium chloride (nacl), by Baxter (1 mentions) Hls module advanced, by Getinge (1 mentions) Ringer s solution, by Baxter (1 mentions) Mannitol, by Baxter (1 mentions) Actrapid, by Novo Nordisk (1 mentions) Heparin, by Leo pharma (1 mentions) Affinity nt, by Medtronic (1 mentions) Rotaflow, by Getinge (1 mentions) Hls set advanced 7, by Getinge (1 mentions)

6 protocols using bio console 560

Establishment of ECMO Perfusion System

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The ECMO perfusion system was assembled according to the clinical standard^{14 (link)}. The ECMO perfusion system has the main closed-loop circuit directly connected to an animal and consists of a centrifugal pump (Bio-Console 560, Medtronic) that drives autologous blood through the oxygenator (Affinity Fusion, Medtronic) into the animal arterial system. The oxygenator is connected to a refrigerated bath (Polystat, Cole-Parmer) for temperature control and the gas blender (Sechrist Industries), for control of dissolved gases and anaesthesia infusion. The perfusion system has a fluid reservoir, which is used to prime the system and hold the supplement fluid. Furthermore, ECMO perfusion system contained the CDI blood parameter module, and the haematocrit/oxygen saturation probe (Terumo Cardiovascular Systems) are connected on the arterial and venous side, respectively, along with the pressure (PendoTECH) and flow sensors (Bio-Probe TX50, Medtronic). All of the probes and sensors of the ECMO perfusion system are connected to a computer to enable data gathering. Detailed schematics are available on request.
The ECMO perfusion system is primed with 1,000 ml 0.9% sodium chloride (Baxter Healthcare) and 5,000 USP units of heparin (Sigma-Aldrich). After initiation of the perfusion protocol, the reservoir is disconnected from the main circuit.

Andrijevic D., Vrselja Z., Lysyy T., Zhang S., Skarica M., Spajic A., Dellal D., Thorn S.L., Duckrow R.B., Ma S., Duy P.Q., Isiktas A.U., Liang D., Li M., Kim S.K., Daniele S.G., Banu K., Perincheri S., Menon M.C., Huttner A., Sheth K.N., Gobeske K.T., Tietjen G.T., Zaveri H.P., Latham S.R., Sinusas A.J, & Sestan N. (2022). Cellular recovery after prolonged warm ischaemia of the whole body. Nature, 608(7922), 405-412.

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Venoarterial ECMO for Cardiogenic Shock

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Venoarterial ECMO support was initiated in patients with systolic arterial hypotension (<80 mm Hg) or other clinical signs of cardiogenic shock, end‐organ failure, or anaerobic metabolism despite optimized supportive therapeutic measures (fluid, inotropes, intra‐aortic balloon pump). The ECMO system consisted of a pump console (Bio‐Console560, Medtronic, Fridley, MN; or Cardiohelp system, Maquet, Germany) and an inline plasma‐tight hollow‐fiber microporous membrane oxygenator (Affinity‐NTTM, Medtronic, Fridley, MN; or HLS module advanced, Maquet, Germany). All parts of the system were routinely checked every 24 hours by the on‐shift intensive care physician or an experienced perfusionist. The complete system was coated with heparin to prevent clotting. If any signs of fibrin deposits or blood clots were present or if blood oxygenation levels declined drastically, the circuit was changed. Ventilator settings were adapted to ensure lung‐protective ventilation with peak airway pressures below 25 cm H₂O and respiratory tidal volumes between 6 and 8 mL/kg. The fraction of inspired oxygen on the oxygenator was adjusted to maintain a target partial pressure of oxygen of 80 to 100 mm Hg.

Bartko P.E., Wiedemann D., Schrutka L., Binder C., Santos‐Gallego C.G., Zuckermann A., Steinlechner B., Koinig H., Heinz G., Niessner A., Zimpfer D., Laufer G., Lang I.M., Distelmaier K, & Goliasch G. (2017). Impact of Right Ventricular Performance in Patients Undergoing Extracorporeal Membrane Oxygenation Following Cardiac Surgery. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 6(8), e005455.

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Ex Vivo Kidney Perfusion Protocol

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After removal from cold storage the kidneys were weighed and prepared for reperfusion on the ex vivo perfusion circuit. The renal artery, vein and ureter were cannulated and the kidney was flushed with 200 mL of cold Ringer’s solution to remove the preservation solution.
Perfusion was carried out using an adapted paediatric cardiac bypass system (Medtronic, Bioconsole 560) as described previously [4 (link), 5 (link)]. The ex vivo perfusion system was primed with 300 mL Ringer’s solution (Baxter Healthcare, Thetford UK), 2.5 g Mannitol (Baxter Healthcare), 12 mL sodium bicarbonate 8.4% (Fresenius Kabi, Runcorn, UK) and 3000 IU heparin (LEO Pharma A/S, Ballerup, Denmark). Whole blood (300 mL) was then added and recirculated to a temperature of 37.4 °C. The blood-based solution was oxygenated with a balance of 95% oxygen/5% CO₂ at a flow rate of 0.1 L/min.
The blood-based solution was circulated continually through the kidney via the renal artery at a mean arterial pressure of 85 mmHg and pump speed of 1500 RPM. A nutrient solution (Synthamin 17 10%, Baxter Healthcare) with 15 mL of sodium bicarbonate 8.4% and 100 IU of insulin added (Actrapid, Novo Nordisk, London, UK) was infused at a rate of 20 mL/h. Glucose 5% (Baxter Healthcare) was infused at a rate of 5 mL/h and Ringer’s solution was used to replace urine output (mL for mL).

Hosgood S.A., Moore T., Kleverlaan T., Adams T, & Nicholson M.L. (2017). Haemoadsorption reduces the inflammatory response and improves blood flow during ex vivo renal perfusion in an experimental model. Journal of Translational Medicine, 15, 216.

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Venoarterial ECMO After Cardiac Surgery

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We prospectively enrolled all patients undergoing venoarterial ECMO support after cardiovascular surgery between February 2002 and December 2009 at the Vienna General Hospital, a university-affiliated tertiary care center in our registry, as previously published [10 (link)]. No exclusion criteria were applied. The study protocol was reviewed and approved by the Ethics Committee of the Medical University of Vienna and conforms to the Declaration of Helsinki; all patients admitted to the Medical University of Vienna provided written consent at hospital admission. The ECMO circuit consisted of a centrifugal pump console (Bio-Console560; Medtronic, New York, NY, USA) with a hollow-fiber membrane oxygenator (Affinity-NTTM; Medtronic). An experienced perfusionist and the on-shift intensive care physician routinely serviced the ECMO circuit once daily. The circuit was changed if blood oxygenation declined sharply or if significant fibrin deposition or clots were present. Under ECMO therapy, lungs were ventilated at peak airway pressures <25 cmH₂O, physiologic respiratory tidal volumes (6 to 8 ml/kg), a respiratory rate (≤10/min), and the fractional inspired oxygen (FiO₂) was reduced to 0.3. FiO₂ was adjusted by using the ECMO circuit to maintain a PO₂ between 80 and 100 mm Hg. A more-detailed description regarding ECMO management was previously published [10 (link)].

Distelmaier K., Winter M.P., Rützler K., Heinz G., Lang I.M., Maurer G., Koinig H., Steinlechner B., Niessner A, & Goliasch G. (2014). Serum butyrylcholinesterase predicts survival after extracorporeal membrane oxygenation after cardiovascular surgery. Critical Care, 18(1), R24.

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Ex Vivo Heart Perfusion System

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Figure 1 depicts the EVHP system with the primed left ventricle. The system consists of a venous reservoir (Affinity Fusion, Medtronic, Minneapolis, Minnesota), an oxygenator with heat exchanger (Affinity Fusion, Medtronic, Minneapolis, Minnesota), a heater (Sarns Dual Heater Cooler Model 11160) and a centrifugal pump (560A, Medtronic, Minneapolis, Minnesota) mounted on to a Medtronic Performer cardiopulmonary bypass machine (Medtronic, Minneapolis, Minnesota), and a Bio-console 560 (Medtronic, Minneapolis, Minnesota).

Xin L., Yao W., Peng Y., Lu P., Ribeiro R., Wei B., Gellner B., Simmons C., Zu J., Sun Y, & Badiwala M. (2020). Primed Left Ventricle Heart Perfusion Creates Physiological Aortic Pressure in Porcine Hearts. ASAIO journal (American Society for Artificial Internal Organs : 1992), 66(1).

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ECMO Console and Oxygenator Selection

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Consoles and oxygenators were selected according to desired treatment modality, expected blood flow, and gas exchange requirements as well as availability. The following consoles were used in the study population: Cardiohelp System (Getinge, Rastatt, Germany), Bio-Console 560 (Medtronic, Minneapolis, MN), Rotaflow (Getinge), Centrimag (Thoratec, Pleasanton, CA), and iLA activve (Xenios, Heilbronn, Germany). The membrane oxygenators contained hollow fibers made of either polymethylpentene -HLS Set Advanced 7.0 (Getinge), A.L.ONE ECMO Adult (Eurosets, Medolla, Italy), PLS Set (Getinge), iLA (Xenios) -or polypropylene -Affinity NT (Medtronic, Minneapolis, MN). Circuit components coated with albumin/heparin, heparin, or phosphorylcholine were used, except in patients with known HIT.

Nagler B., Hermann A., Robak O., Robak O., Schellongowski P., Buchtele N., Bojic A., Schmid M., Zauner C., Winter M.P., Heinz G., Ullrich R., Kraft F., Wiedemann D., Bernardi M.H., Staudinger T, & Lamm W. (2021). Incidence and Etiology of System Exchanges in Patients Receiving Extracorporeal Membrane Oxygenation. ASAIO journal (American Society for Artificial Internal Organs : 1992), 67(7).

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