Inveon pet scanner

Manufactured by Siemens

Sourced in United States, Germany

The Inveon PET scanner is a preclinical imaging system designed for small animal research. It provides high-resolution, high-sensitivity positron emission tomography (PET) imaging capabilities. The Inveon PET scanner is capable of acquiring three-dimensional (3D) PET data for small animals such as mice and rats.

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Lab products found in correlation

Asipro vw software, by Siemens (5 mentions) Asipro vm, by Siemens (4 mentions) Is v1.4.3 sp1, by Siemens (2 mentions) Asipro software, by Siemens (1 mentions) Balb c nude mice, by Charles River Laboratories (1 mentions) Matrigel, by BD (1 mentions) Inveon research workplace, by Siemens (1 mentions) Nano series, by Malvern Panalytical (1 mentions) Tecnai 12, by Thermo Fisher Scientific (1 mentions) Wallac wizard gamma counter, by PerkinElmer (1 mentions) Asipro, by Siemens (1 mentions)

Close spelling variants of this product

Inveon PET small animal scanners Inveon combined micro-PET/CT scanner Inveon Small Animal PET/SPECT/CT scanner Inveon animal PET scanner Inveon™ Hybrid Micro‐PET/CT Scanner Inveon dedicated small-animal PET scanner Inveon Multimodality PET/computed tomography (CT) scanner Inveon micro-PET/CT rodent model scanner Inveon trimodality PET/SPECT/CT scanner Inveon Micro-CT/PET scanner

34 protocols using inveon pet scanner

PET Imaging of Cannabinoid Receptor 1

Cited 3 times

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PET scans were acquired by an Inveon PET scanner (Siemens Medical Solutions, Knoxville, TN, USA). Sprague-Dawley rats were kept under anesthesia with 1–2% (v/v) isoflurane during the scan. The radiotracer (ca. 1 mCi/150–200 μL) was injected via a preinstalled catheter via tail vein. A dynamic scan in 3D list mode was acquired for 90 min. For pretreatment studies, 10 (3 mg/kg), KML29 (3 mg/kg) or URB597 (3 mg/kg) dissolved in 300 μL saline containing 5% ethanol, 5% DMSO and 5% Tween^® 80 was injected at 30 min via the tail vein catheter before the injection of 16. For displacement (“chase”) studies, KML29 (3 mg/kg) was injected at 15 min via the tail vein catheter after the injection of 16. As we previously reported,^{46 (link), 90 (link), 91 (link)} the PET dynamic images were reconstructed using ASIPro VW software (Analysis Tools and System Setup/Diagnostics Tool, Siemens Medical Solutions). Volumes of interest, including the whole brain, cerebral cortex, cerebellum, striatum, thalamus and pons were placed referencing the MRI template software. The radioactivity was decay-corrected and expressed as the standardized uptake value. SUV = (radioactivity per mL tissue/injected radioactivity) x body weight.

Cheng R., Mori W., Ma L., Alhouayek M., Hatori A., Zhang Y., Ogasawara D., Yuan G., Chen Z., Zhang X., Shi H., Yamasaki T., Xie L., Kumata K., Fujinaga M., Nagai Y., Minamimoto T., Svensson M., Wang L., Du Y., Ondrechen M.J., Vasdev N., Cravatt B.F., Fowler C., Zhang M.R, & Liang S.H. (2018). In vitro and In vivo evaluation of 11C-labeled azetidine-carboxylates for imaging monoacylglycerol lipase by PET imaging studies. Journal of medicinal chemistry, 61(6), 2278-2291.

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PET Imaging of Hippocampal Function

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¹⁸F-FDG (1 mCi) was injected via the tail vein, and the injected mice were anesthetized with 2% isoflurane in 100% oxygen. A Siemens Inveon PET scanner (Siemens Medical Solutions, Malvern, PA, USA) was used for PET imaging. The transverse resolution was <1.8 mm at the center. After allowing uptake for 10 min, 30 min of emission PET data were acquired with a 350-650 keV energy window. The list-mode PET data were reconstructed using 3D reprojection methods. The pixel size of the reconstructed images was 0.15 × 0.15 × 0.79 mm³. Attenuation, scatter corrections, and normalization were performed. To identify regional differences between groups, a region of interest (ROI) was drawn in the hippocampus. The maximal value of the ROI was calculated within ROI regions to avoid a partial volume effect. ROIs were drawn on at least 10 subsequent coronal sections of PET data, and then the averaged value of the PET counts of individual mice were used for statistics. Asipro Software (Siemens Healthineers, Erlangen, Germany) was used for ROI delineation. For normalization of body weight and injected dose differences, the PET counts of the hippocampus were normalized to the whole-brain counts.

Yang H., Park S.Y., Baek H., Lee C., Chung G., Liu X., Lee J.H., Kim B., Kwon M., Choi H., Kim H.J., Kim J.Y., Kim Y., Lee Y.S., Lee G., Kim S.K., Kim J.S., Chang Y.T., Jung W.S., Kim K.H, & Bae H. (2022). Adoptive therapy with amyloid-β specific regulatory T cells alleviates Alzheimer's disease. Theranostics, 12(18), 7668-7680.

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PET Imaging of Tumor-Bearing Mice

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PET scans were conducted using
an Inveon PET scanner (Siemens Medical Solutions, Knoxville, TN),
which provides 159 transaxial slices with 0.796 mm (center-to-center)
spacing, a 10 cm transaxial field of view, and a 12.7 cm axial field
of view. All list-mode acquisition data were sorted into three-dimensional
(3D) sinograms, which were then Fourier rebinned into two-dimensional
(2D) sinograms (frames × min: 4 × 1, 8 × 2, 8 ×
5). PET dynamic images were reconstructed with filtered back projection
using a Hanning filter and a Nyquist cutoff of 0.5 cycles/pixel. Tumor
bearing mice were kept in the prone position under anesthesia with
1–2% (v/v) isoflurane during the scan. The tracers (8–17
MBq/200–500 μL) in saline were injected via a preinstalled
tail vein catheter. Immediately after the injection, a dynamic scan
in 3D list mode was acquired for 60 min. Maximum intensity projection
images were obtained for tumor bearing mice. PET dynamic images were
reconstructed by filtered back projection using a Hanning filter with
a Nyquist cutoff of 0.5 cycles/pixel, which was summed using analysis
software (ASIPro VM, Siemens Medical Solutions). Volumes of interest,
including the tumors and muscle, were placed using the ASIPro software.
The radioactivity was decay-corrected for the injection time and expressed
as the percent of the total injection dose per gram tissue (%ID/g).

Hu K., Shang J., Xie L., Hanyu M., Zhang Y., Yang Z., Xu H., Wang L, & Zhang M.R. (2020). PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide. ACS Omega, 5(15), 8508-8514.

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PET Imaging of Radiotracer Uptake in Rats

Cited 3 times

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The general procedure for PET studies was described previously^{39 (link), 41 (link)} with minor modification in this work. Briefly, PET scans were carried out by an Inveon PET scanner (Siemens Medical Solutions, Knoxville, TN, USA). Sprague-Dawley rats were kept under anesthesia using 1–2% (v/v) isoflurane during the scan. The radiotracer (ca. 1 mCi / 150 μL) was injected into the tail vein via a preinstalled catheter. A dynamic scan in 3D list mode was acquired for 90 min. For pretreatment studies, a solution of KML29 (3 mg/kg) in 300 μL saline containing 10% ethanol and 5% Tween^® 80 was injected via the pre-embedded tail vein catheter at 30 min prior to tracer injection. As we previously reported,^{39 (link), 77 (link), 78 (link)} the PET dynamic images were reconstructed using ASIPro VW software (Analysis Tools and System Setup/Diagnostics Tool, Siemens Medical Solutions). Volumes of interest, including the whole brain, hippocampus, cerebral cortex, cerebellum, striatum, thalamus, and pons were placed using ASIPro software. The radioactivity was decay-corrected and expressed as the standardized uptake value. SUV = (radioactivity per mL tissue / injected radioactivity) × body weight.

Chen Z., Mori W., Deng X., Cheng R., Ogasawara D., Zhang G., Schafroth M.A., Dahl K., Fu H., Hatori A., Shao T., Zhang Y., Yamasaki T., Zhang X., Rong J., Yu Q., Hu K., Fujinaga M., Xie L., Kumata K., Gou Y., Chen J., Gu S., Bao L., Wang L., Lee Collier T., Vasdev N., Shao Y., Ma J.A., Cravatt B.F., Fowler C., Josephson L., Zhang M.R, & Liang S.H. (2019). Design, synthesis and evaluation of reversible and irreversible monoacylglycerol lipase positron emission tomography (PET) tracers using a ‘tail switching’ strategy on a piperazinyl azetidine skeleton. Journal of medicinal chemistry, 62(7), 3336-3353.

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Micro-PET Imaging of 18F-FDG Uptake

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¹⁸F-FDG was synthesized according to the method developed by Ido [21 (link)] to a purity of > 95% in the Jiangsu Atomic Energy Laboratory (Jiangsu, China). Micro-PET images were acquired with an Inveon PET scanner (Siemens Preclinical Solutions, LLC, Knoxville, TN, USA). Before scanning, rats were fasted for 8–12 h, after which 7.4–11.1 MBq of ¹⁸F-FDG was injected via the tail vein and PET scans were obtained 60 min later. Anesthesia was maintained during the PET scans with 1.5% isoflurane in 100% oxygen at 1.5 L/min. For the scans, rats were placed prone on the bed of micro-PET, and the limbs were fixed with tape. A 10-min static single-frame scan was acquired with a small-animal PET camera, and images were reconstructed by ordered subsets expectation maximization (OSEM)-3D IAW (Siemens Preclinical Solutions).
Two experienced nuclear medicine physicians examined all PET images in a double-blinded fashion. Regions of interest (ROIs) in the right lungs were drawn using vendor software (IS_v1.4.3 SP1; Siemens Healthineers, Erlangen, Germany). The SUV was calculated as an absolute measure of ¹⁸F-FDG uptake in an ROI as:
[(measured activity concentration, in kBq/mL)/(injected dose, in kBq/body weight, in g)].
All animals were weighed before scanning. SUV_max and SUV_mean were defined as the maximum and mean tracer uptake in the ROIs.

Guo M., Qi L., Zhang Y., Shang D., Yu J, & Yue J. (2019). 18F-Fluorodeoxyglucose positron emission tomography may not visualize radiation pneumonitis. EJNMMI Research, 9, 112.

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Biodistribution of Ga-68/Lu-177 Labeled Peptides

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Animal experiments were conducted in compliance with the German animal protection laws. For in vivo small-animal PET imaging and organ distribution studies, 8-wk-old BALB/c nude mice (Charles River Laboratories) were inoculated subcutaneously at the right shoulder with 5 • 10 6 tumor cells in Matrigel (BD Bioscience).
Xenografts were grown to a 10-to 15-mm diameter. The mice were anesthetized using isoflurane inhalation, and a 100-mL phosphatebuffered saline solution containing 68 Ga-DOTA-SFLAP3 (HNO97, 37.9 MBq; HNO399, 26 MBq; HNO223, 27 MBq) or 68 Ga-DOTA-SFITGv6 (HNO97, 30 MBq; HNO399, 34 MBq; HNO223, 34 MBq) was injected into the tail vein. Three-dimensional PET images were captured (Siemens Inveon PET scanner) as previously described (12) . To assess the biodistribution, 100 mL of a 20 nM 177 Lu-DOTA-SFLAP3 or 177 Lu-DOTA-SFITGv6 solution (1 MBq) were administered as a bolus injection into the tail vein. At each time point (30, 60, 120, 240, 360 min), we sacrificed 3 animals, collected peripheral blood and the respective organs, weighed the tissues, and measured the radioactivity using a g-counter. Radioactivity (MBq) was expressed as percentage of injected dose (%ID) per gram of tissue.

Roesch S., Lindner T., Sauter M., Loktev A., Flechsig P., Müller M., Mier W., Warta R., Dyckhoff G., Herold-Mende C., Haberkorn U, & Altmann A. (2018). Comparison of the RGD Motif-Containing α_vβ₆ Integrin-Binding Peptides SFLAP3 and SFITGv6 for Diagnostic Application in HNSCC. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(11).

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Quantitative PET Imaging of GPC3 Tumor

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Imaging studies were performed using the Siemens Inveon PET scanner. Whole-body imaging was performed on mice on a temperature-controlled bed, anesthetized with 1.5%–2.5% isoflurane with real-time respiratory monitoring. Tumor-bearing mice selected by IVIS imaging were injected with approximately 7.4 MBq (200 μCi) of ⁸⁹Zr-αGPC3-F(ab′)2 (∼50 ug antibody) via the tail vein. Control animals (n = 3) were coinjected with 1 mg of unlabeled αGPC3 as a competition assay. Imaging time points (duration) were as follows: 4 h (20 min), 24 h (30 min), and 72 h (60 min). Details are found in the supplemental data.

Sham J.G., Kievit F.M., Grierson J.R., Chiarelli P.A., Miyaoka R.S., Zhang M., Yeung R.S., Minoshima S, & Park J.O. (2014). Glypican-3–Targeting F(ab′)2 for 89Zr PET of Hepatocellular Carcinoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(12), 2032-2037.

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In vivo PET Imaging of AuNR Biodistribution

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In vivo static PET imaging was performed using an Inveon® PET scanner (Siemens, USA). Approximately 3.8 MBq of ⁶⁴Cu labeled AuNR of each size was injected intravenously to tumor-bearing mice. Five mice were used for each size of AuNR. Sequential PET scans were performed at 1, 3, 5, 8, 12, 24 and 48 h post-injection. The acquisition time was 10 min for the scans before 24 h post-injection and 15 min for the scan at 48 h post injection. The mice were anesthetized by inhalation of isoflurane (1% in 1 L/min oxygen) during each scan. PET images were reconstructed using 3D ordered-subsets expectation maximum followed by maximum a posteriori algorithm with a smoothing parameter of 0.1 (OSEM-3D-MAP).

Tong X., Wang Z., Sun X., Song J., Jacobson O., Niu G., Kiesewetter D.O, & Chen X. (2016). Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery. Theranostics, 6(12), 2039-2051.

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Radiolabeling and Imaging of PRGD2 Peptide

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A lyophilized kit for labeling the PRGD2 peptide purchased from the Jiangsu Institute of Nuclear Medicine was employed according to a previously published study (15 (link)). The radiochemical purity of ¹⁸F−RGD exceeded 95%, and its specific radioactivity exceeded 37 GBq (1,000 mCi)/µmol. All micro-PET images were obtained with an Inveon PET scanner (Siemens Preclinical Solutions, LLC, Knoxville, TN, USA) using ¹⁸F−RGD. With the assistance of the positioning laser from the Inveon system, each tumor-bearing mouse was placed with its tumor located in the center of the field of view to achieve the highest imaging sensitivity. ¹⁸F-RGD PET scans were performed 60 min after tail-vein injection of ¹⁸F−RGD (2.4−3.5 MBq) under isoflurane anesthesia with 1.5% isoflurane in 100% oxygen at a flow rate of 1.5 L/min. The PET scans were acquired on a combined PET/CT scanner for 5 min per field of view. The PET images were reconstructed and analyzed using the OSEM−3D IAM software program (IS_v1.4.3 SP1; Siemens Preclinical Solutions, LLC).

Wu L., Liu J., Wang S., Bai M., Wu M., Gao Z., Li J., Yu J., Liu J, & Meng X. (2022). Negative Correlation Between 18F-RGD Uptake via PET and Tumoral PD-L1 Expression in Non-Small Cell Lung Cancer. Frontiers in Endocrinology, 13, 913631.

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Quantitative PET Imaging of Neurochemical Targets

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PET scans were acquired by an Inveon PET scanner (Siemens Medical Solutions, Knoxville, TN, USA). Sprague-Dawley rats were kept under anesthesia with 1–2% (v/v) isoflurane during the scan. The radiotracer (ca. 1 mCi/150–200 µL) was injected via a preinstalled catheter via tail vein. A dynamic scan in 3D list mode was acquired for 60 min. For pretreatment studies, QCA (1 mg/kg) pre-dissolved in 300 µL saline containing 10% ethanol and 5% Tween^® 80 was injected at 30 min via the tail vein catheter before the injection of [¹¹C]QCA.
As we previously reported,^{78 (link),79 (link)} the PET dynamic images were reconstructed using ASIPro VW software (Analysis Tools and System Setup/Diagnostics Tool, Siemens Medical Solutions). Volumes of interest, including the whole brain, cerebral cortex, cerebellum, striatum, thalamus and pons were placed using ASIPro software. The radioactivity was decay-corrected and expressed as the standardized uptake value. SUV = (radioactivity per mL tissue/injected radioactivity) × body weight.

Zhang X., Kumata K., Yamasaki T., Cheng R., Hatori A., Ma L., Zhang Y., Xie L., Wang L., Kang H.J., Sheffler D.J., Cosford N.D., Zhang M.R, & Liang S.H. (2017). Synthesis and preliminary studies of a novel negative allosteric modulator [11C]QCA for imaging of metabotropic glutamate receptor 2. ACS chemical neuroscience, 8(9), 1937-1948.

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