Ifn λ2 3

Manufactured by R&D Systems

Sourced in United States

IFN-λ2/3 is a recombinant human protein that belongs to the type III interferon family. It is a cytokine that plays a role in the immune response.

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Lab products found in correlation

Il 20, by R&D Systems (1 mentions) Il 24, by R&D Systems (1 mentions) Cxcl1, by R&D Systems (1 mentions) Ifn γ, by R&D Systems (1 mentions) Ifn γ, by BioLegend (1 mentions) Ifn β, by R&D Systems (1 mentions) Multiplex immunoassay, by Merck Group (1 mentions) Ifn γ, by BD (1 mentions)

3 protocols using ifn λ2 3

Measuring Cytokine Levels in BAL, Lung, and Serum

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Levels of IFN-γ, CXCL-1, IFN-λ2/3, IL-20, IL-24 (R&D systems, Minneapolis, MN, United States) and IL-19 (Invitrogen, Waltham, MA, United States) were determined in BAL, lung and serum by enzyme-linked immunosorbent assay (ELISA) using the manufacturer’s recommendation.

Le Roux M., Ollivier A., Kervoaze G., Beke T., Gillet L., Pichavant M, & Gosset P. (2021). IL-20 Cytokines Are Involved in Epithelial Lesions Associated with Virus-Induced COPD Exacerbation in Mice. Biomedicines, 9(12), 1838.

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Quantifying Immune Mediators in BALF

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Commercially available ELISA kits were used to quantify IFN-β (R&D Systems, DY8234-05), IFN-λ2/3 (R&D Systems, DY1789B-05), IFN-γ (BioLegend, 430804), Myeloperoxidase (R&D Systems, DY3667) and Neutrophil Elastase/ELA2 (R&D Systems, DY4517-05) in BALF following the manufacturer’s protocol.

Xue Y., Pan L., Vlahopoulos S., Wang K., Zheng X., Radak Z., Bacsi A., Tanner L., Brasier A.R., Ba X, & Boldogh I. (2023). Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1. Frontiers in Immunology, 14, 1161160.

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Lung Cytokine Profiling in Mice

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A single lung lobe from each mouse was excised and snap frozen before being homogenised in buffers recommended in the manufacturer's instructions. Levels of IL-5, IL-13, IFNγ (BD Biosciences; PharMingen), IFNα, IFNβ (Verikine; PBL Assay Science), CCL7/MCP3 and IFNλ2/3 (R&D Systems) were determined in clarified lung lysates by ELISA. CCL2/MCP1, CCL3/MIP1α, CCL4/MIP1β, CXCL9/MIG and CXCL10/IP10 were measured by employing a Multiplex Immunoassay (Millipore). All concentrations were normalised to lung weight.

Hatchwell L., Collison A., Girkin J., Parsons K., Li J., Zhang J., Phipps S., Knight D., Bartlett N.W., Johnston S.L., Foster P.S., Wark P.A, & Mattes J. (2015). Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia. Thorax, 70(9), 854-861.

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