Bnii instrument

Manufactured by Siemens

Sourced in United States

The BNII instrument is a laboratory equipment product manufactured by Siemens. It is designed to perform automated biochemical analysis. The core function of the BNII instrument is to measure and analyze various biomolecules and compounds in a sample.

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Lab products found in correlation

Bcs xp coagulometer, by Siemens (1 mentions) Cobas 6000 system, by Roche (1 mentions)

5 protocols using bnii instrument

Serum Biomarkers in Patient Samples

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When patients were hospitalized, blood samples were collected and taken into tubes containing 0.1% EDTA for serum analyses at the first time. Serum complement C1q (mg/L) levels were measured by immunity transmission turbidimetry using Siemens BNII instrument, the concentrations of relevant lipoprotein markers, such as total cholesterol (TC) (mmol/L), total triglycerides (TG) (mmol/L), LDL-C (mmol/L), HDL-C (mmol/L), very-low-density lipoprotein cholesterol (VLDL-C) and Lipoprotein (a) (mg/dL) were measured by electro-chemiluminescence immunoassay (Roche Diagnostics, Indianapolis, IN). Plasma haemoglobin A1c (HbA1c) (%), creatine (CREA) (μmol/L) and other laboratorial parameters were measured by a biochemical analyzer according to standard test protocols (Hitachi-7600, Tokyo, Japan).

Wang Y., Zheng J., Li Q., Ma Y., Liu C., Deng J, & Gao D. (2024). The relationship between complement C1q and coronary plaque vulnerability based on optical coherence tomography analysis. Scientific Reports, 14, 9477.

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Automated Biomarker Quantification Methods

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Assays used in the calculation of the BioPredictive algorithms were run on routine automated platforms using standard reagents. Total cholesterol, triglycerides, glucose, ALT, AST, γ-glutamyl transpeptidase (GGT) and total bilirubin were run on a Beckman Coulter (Beckman Coulter, Brea, California, USA) AU series instruments. Haptoglobin, alpha-2-macroglobulin and apo A1 were run on the Siemens (Siemens Healthcare Diagnostics, Tarrytown, New York, USA) BNII instrument.

Bril F., McPhaul M.J., Caulfield M.P., Castille J.M., Poynard T., Soldevila-Pico C., Clark V.C., Firpi-Morell R.J., Lai J, & Cusi K. (2018). Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus. Journal of Investigative Medicine, 67(2), 303-311.

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Lipid and Inflammatory Biomarker Evaluation

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Blood samples were collected after at least 8 h overnight fasting. TC, LDL-C, FPG, HbA1C, plasma triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), uric acid (UA) and cystatin C (Cys C) were measured by standard method in the clinical laboratory of the same hospital. Plasma hsCRP was analyzed by immunophelometry method using Siemens hsCRP immumoreagent on a Siemens BNII instrument.

Sun L., Liu X., Li W, & Jia D. (2019). HDL-C to hsCRP ratio is associated with left ventricular diastolic function in absence of significant coronary atherosclerosis. Lipids in Health and Disease, 18, 219.

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Turbidimetric Scatter Rate Assay

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Rate scatter turbidimetry (Siemens BNII instrument and its supporting reagents).

Wang Y., Wang T., Cai M., Zhu S., Song L, & Wang Q. (2021). Expression and existence forms of mast cell activating molecules and their antibodies in systemic lupus erythematosus. Immunity, Inflammation and Disease, 10(2), 235-240.

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Automated Clinical Laboratory Analyses

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This article is protected by copyright. All rights reserved.
(Alifax). Complement component 3 (C3) and 4 (C4) were analyzed on BNII instrument (Siemens Healthcare) that uses the nephelometric technology. Prothrombin time and plasma fibrinogen concentration were analyzed on BCS-XP coagulometer (Siemens Healthcare).
Albumin/globulin ratio was determined using the CAPILLARYS electrophoresis instrument (Sebia).
Lipid profile analytes including total cholesterol, high density lipoproteins (HDL) and triglycerides were determined by specific colorimetric enzymatic methods on Cobas 6000 system (Roche Diagnostic). Urine pH and urinary specific gravity values were determined by using Atlas instrument (Siemens Healthcare), and urine sediment was analyzed on Iris instrument (Beckman Coulter). The differential count of leukocytes was performed on the automated cell counters Sysmex-XE 2100 (Dasit) (Supplementary Table 1).

Cortelazzo A., De Felice C., Guerranti R., Signorini C., Leoncini S., Zollo G., Leoncini R., Timperio A.M., Zolla L., Ciccoli L, & Hayek J. (2016). Expression and oxidative modifications of plasma proteins in autism spectrum disorders: Interplay between inflammatory response and lipid peroxidation. Proteomics. Clinical applications, 10(11).

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