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Molt-4, Jurkat (clone E6-1), LS174T, HL-60, WEHI-3, HUVEC, and human dermal fibroblasts were purchased from ATCC. Lox were a kind gift from Dr. Oystein Fodstad (Oslo University Hospital). MKN45, Colo205, MDA-MB-231, and MCF7 were a kind gift from Dr. Henrik Clausen (University of Copenhagen). Tn(−) and Tn(+) LS174T were subcloned from a mixed population as previously described^{19 (link)}. Lox and Jurkat were transfected with full length Cosmc or empty vector (pcDNA3.1+) and selected by G418. Tn(−) cells were further sorted by FACS. Molt-4, Jurkat, Lox, HL-60, MKN45, and Colo205 were cultured in RPMI (Corning) supplemented with 10% FBS and 2% P/S. LS174T, MDA-MB-231, and MCF7 were cultured in DMEM (Corning) supplemented with 10% FBS and 2% P/S. MCF7 were further supplemented with 0.01 mg/ml insulin. WEHI-3 were cultured in Iscove’s (Corning) supplemented with 10% FBS, 0.05 mM 2-ME, and 2% P/S. HUVEC and human dermal fibroblasts were cultured with endothelial cell growth kit-VEGF (ATCC) and fibroblast growth kit- low serum (ATCC) as instructed. All cells were cultured on plastic, except HUVECs, which were cultured on plastic pre-coated with 0.1% gelatin. We did not perform independent verification of cell lines or testing for mycoplasma.