All reagents were purchased from commercial sources and used without further purification unless otherwise specified. Chromatographic purifications were carried out in Fisher 230–400 mesh silica gel unless otherwise specified. Microwave reactions were conducted with a Biotage Initiator microwave reactor. High resolution mass spectra were collected on a Waters LCT Premier XE ESI-TOF mass spectrometer. Optical rotations were measured using an automated polarimeter in a 1 dm cell. NMR spectra were collected at 400, 500, or 600 MHz as indicated. 1H NMR spectra were assigned with the aid of 1D and 2D techniques including COSY, HSQC, HMBC, and TOCSY.
Lct premier xe esi tof mass spectrometer
Manufactured by Waters Corporation
Sourced in United States
The LCT Premier XE ESI-TOF mass spectrometer is a high-resolution, time-of-flight mass spectrometer equipped with electrospray ionization (ESI) source. It is designed to provide accurate mass measurement and identification of a wide range of analytes.
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3 protocols using lct premier xe esi tof mass spectrometer
1
Purification and Characterization of Organic Compounds
2
Quantification of Ado and HX Metabolites
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Ado and HX identification
and quantification
were performed on an Acquity UHPLC chromatograph equipped with a photodiode-array
system and coupled to a LCT Premier XE ESI-TOF mass spectrometer (Waters,
Milford, MA, USA). Chromatographic separation was carried out using
an Acquity BEH C18 (100 × 2.1 mm, 1.7 μm) reverse phased
column (Waters, Mildford, USA). The elution buffers were 0.1% formic
acid in water (A) and acetonitrile (B), and the linear gradient method
consisted of 99% A over 1.5 min, 99–1% over 1.5–6 min,
1% for 2 min, and 99% for 2 min before next injection. Total run time
was 10 min, injection volume was 5 μL, and the flow rate was
set at 300 μL/min. Both metabolites were detected and quantified
after monitoring the UV signal at 254 nm of wavelength.
and quantification
were performed on an Acquity UHPLC chromatograph equipped with a photodiode-array
system and coupled to a LCT Premier XE ESI-TOF mass spectrometer (Waters,
Milford, MA, USA). Chromatographic separation was carried out using
an Acquity BEH C18 (100 × 2.1 mm, 1.7 μm) reverse phased
column (Waters, Mildford, USA). The elution buffers were 0.1% formic
acid in water (A) and acetonitrile (B), and the linear gradient method
consisted of 99% A over 1.5 min, 99–1% over 1.5–6 min,
1% for 2 min, and 99% for 2 min before next injection. Total run time
was 10 min, injection volume was 5 μL, and the flow rate was
set at 300 μL/min. Both metabolites were detected and quantified
after monitoring the UV signal at 254 nm of wavelength.
3
Spectroscopic Characterization of Compounds
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