Advia centaur xp

Manufactured by Siemens

Sourced in Germany, United States, Switzerland, Ireland, China, Japan, Croatia, United Kingdom, Sweden

The ADVIA Centaur XP is an automated immunoassay analyzer designed for in vitro diagnostic testing. It is capable of performing a wide range of immunoassay tests, including those for hormones, cardiac markers, infectious diseases, and more. The system features advanced automation and processing capabilities to enable efficient and high-throughput testing.

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Lab products found in correlation

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Close spelling variants of this product

ADVIA Centaur (282 citations) ADVIA Centaur XP Immunoassay System (81 citations) Centaur XP (61 citations) ADVIA Centaur XP analyzer (18 citations) ADVIA Centaur XP system (15 citations) ADVIA Centaur XP analyser (4 citations) ADVIA Centaur XP platform (2 citations) ADVIA Centaur® XP Immunoassay System kits (2 citations) ADVIA Centaur® XP TnI-Ultra (2 citations) ADVIA Centaur XP immunoassay analyzer (2 citations)

262 protocols using advia centaur xp

Thyroid Function Biomarker Assessment

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In cohort A, fasting blood samples from all study visits were drawn and stored at −20°C until analysis. After study completion, plasma was analyzed for TSH and free T4 (FT4) by a two-site chemiluminescent immunometric assay on Cobas 8000 (Roche Diagnostics). The coefficients of variation (CVs) for TSH were 8.3% and 4.2% at levels of 0.084 and 11.3 mIU/L, respectively; for FT4, the CVs were 7.1% and 4.4% at levels of 17 and 33 pmol/L, respectively (20 (link)).
In cohort B, blood samples were analyzed during each visit. TSH and FT4 were analyzed by a chemiluminescent immunoassay on ADVIA Centaur XP or Centaur CP (Siemens). The CVs for TSH were 8.17% and 6.95% at levels of 0.287 and 6.94 mIU/L, respectively; for FT4, the CVs were 8.0% and 3.1% at levels of 11.7 and 25.5 pmol/L, respectively.
TPOAb were analyzed using different commercial methods employed routinely at the local hospital laboratories. In cohort A, TPOAb were measured using AutoDELFIA (PerkinElmer). In cohort B, TPOAb were determined by a chemiluminescent immunoassay on ADVIA Centaur XP (Siemens), and the CV was 5.7%. The cutoff value defining a positive value was 60 kIU/L.

Riis K.R., Larsen C.B., Medici B.R., Jensen C.Z., Winther K.H., Larsen E.L., Ellervik C., la Cour J.L., Hegedüs L., Brix T.H., Poulsen H.E., Knop F.K., Nygaard B, & Bonnema S.J. (2023). Hypothyroid women have persistently higher oxidative stress compared to healthy controls. European Thyroid Journal, 12(6), e230167.

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Thyroid Function Biomarker Measurement

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TSH was measured with the immune method of anti-FITC monoclonal antibody (ADVIA Centaur XP, Siemens Healthcare, Erlangen, Germany), fT3 and fT4 with the chemiluminescent immunoassay method (ADVIA Centaur XP, Siemens Healthcare, Erlangen, Germany), iPTH with the chemiluminescent immunoassay method (IMMULITE® 2000, Siemens Healthcare, Erlangen, Germany) and calcium with the CPC method (ADVIA 2400, Siemens Healthcare, Erlangen, Germany). Free T4 and fT3 were measured only in cases of high or low TSH. Normal levels of TSH were defined as 0.55–4.78 mE/L, fT4 11.5–22.7 pmol/L, fT3 4.6 pmol/L. Hypothyroidism was interpreted as increased TSH with normal or reduced fT3 and fT4 and as substitution of levothyroxine [27 (link)]. Hyperthyroidism was interpreted as treatment with thyreostatic drugs or reduced TSH with normal or increased fT3 and fT4 [28 (link)].

Rakusa M., Vrtovec B., Poglajen G., Janez A, & Jensterle M. (2020). Endocrine disorders after heart transplantation: national cohort study. BMC Endocrine Disorders, 20, 54.

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Thyroid Function Biomarkers Analysis

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TSH, FT₃ and FT₄ were measured with an automated direct chemoluminescence method (Advia Centaur XP, Siemens Healthcare Diagnostics, Erlangen, Germany). TSH is traceable to the 3rd International Standard for TSH (WHO, IRP 81/565). A TSH range from 0.006 to 160 mU/l was linear, and coefficient of variations of inter-assay imprecision ranged from 0.9% to 2.4%. Reference intervals were laboratory established and pre-evaluated for the local population, using 10–23 pmol/l for FT₄, 3.1–6.8 pmol/l for FT₃ and 0.4–4.0 mU/l for TSH (23) (link).
TPO-Abs were determined by a competitive chemoluminescence method (Advia Centaur XP, Siemens Healthcare Diagnostics, reference range <60 U/ml) and TSH-R Abs by competitive ELISA (Euroimmun AG, Lübeck, Germany, reference range <2 U/l).

Midgley J.E., Larisch R., Dietrich J.W, & Hoermann R. (2015). Variation in the biochemical response to l-thyroxine therapy and relationship with peripheral thyroid hormone conversion efficiency. Endocrine Connections, 4(4), 196-205.

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Menstrual Cycle Hormonal Assessment

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Every subject who met the inclusion criteria had an appointment scheduled specifically according to her menstrual cycle: one of the first 6 days of menstruation for women with identifiable menstrual cycles, and any day at their convenience for women with irregular menstrual cycles (i.e., the interval between menstrual periods of more than 2 months). Subjects’ serum estradiol, testosterone, and progesterone levels were assessed during their appointments. Fasting blood samples were collected from all participants in the early morning. The serum concentrations of these sex hormones were measured using the Siemens ADVIA Centaur XP Immunoassay System (ADVIA Centaur XP, Siemens Healthcare Diagnostics Inc., New York, USA) in the Department of Clinical Laboratories in the Third Affiliated Hospital of Sun Yat‐sen University.

Han H., Xia X., Zheng H., Zhong Z., Zhao C., Wang X, & Zhi X. (2022). Factors associated with the high susceptibility to depression of women during the perimenopause. Brain and Behavior, 13(1), e2826.

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Automated Thyroid Function Testing

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TSH, FT3 and FT4 were measured with an automated direct chemoluminescence method (Advia Centaur XP, Siemens Healthcare Diagnostics, Erlangen, Germany). For TSH, the 3rd International Standard for TSH (WHO, IRP 81/565) was used, the range from 0.006 to 160.03 mU/l was linear, and CVs of inter-assay imprecision ranged from 0.9 % to 2.4 %. Laboratory-established and extensively evaluated reference intervals were used, 0.4-4.0 mU/l for TSH, 10-23 pmol/l for FT4, and 3.1-6.8 pmol/l for FT3. Thyroid peroxidase antibodies (TPO-Ab) were determined by a competitive chemoluminescence method (Advia Centaur XP, Siemens Healthcare Diagnostics, Erlangen, Germany, reference range < 60 U/ml) and TSH-receptor antibodies (TSH-R Ab) by a competitive ELISA (Euroimmun AG, Lübeck, Germany, reference range < 2 U/l).

Hoermann R., Midgley J.E., Larisch R, & Dietrich J.W. (2015). Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(9).

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Serum CEA and CA19.9 Immunoassay Protocol

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CEA was assayed using an immune radiometric assay (ADVIA Centaur XP (Siemens Diagnostics, Tarrytown, NY, USA), and the threshold for a positive result was 10 ng/ml. The assay was performed based on the manufacturer's instructions.
Serum CA19.9 determination CA19.9 was assayed with an immunoradiometric assay (ADVIA Centaur XP (Siemens Diagnostics, Tarrytown, NY, USA)), and the threshold for a positive result was 37 ng/ml. The assay was carried out based on the manufacturer's instructions

Aziz M.A.A., Ahmed E.A., Elbanna A., Halim R.A., Afifi K.S., & Nouh H. (2020). Role of circulating miRNA-17-3P as a potential diagnostic biomarker for sporadic colon cancer in Egyptian cohort. Egyptian Liver Journal, 10(1).

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Plasma NE and Serum Cortisol Analysis

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Peripheral venous blood samples for plasma NE and serum cortisol analyses were drawn from participants by professional nurses following standard laboratory procedures for assays. For each subject, 5 ml (mL) of venous blood was extracted using a heparin anticoagulation vacuum tube. Levels of plasma NE were analyzed using high-performance liquid chromatography (HPLC, Agilent 1200 series, Agilent Technology, USA). Serum cortisol levels were analyzed by chemiluminescent immunoassay using ADVIA Centaur and ADVIA Centaur XP systems (ADVIA Centaur XP, Siemens, USA). The ADVIA Centaur cortisol assay is a competitive immunoassay using direct chemiluminescent technology.

Kim N., Kim M.J., Hughes T.L., Kwak H, & Kong I.D. (2020). Relationships of internet gaming reasons to biological indicators and risk of internet gaming addiction in Korean adolescent male game users. BMC Psychiatry, 20, 341.

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Metabolic and Hormonal Profiling in Women

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Blood samples were drawn from an antecubital vein between 8:00 and 10:00 am, after a 12-hour overnight fast. Samples were obtained between days 2 and 10 of the cycle, or on any day in amenorrheic women.
Total cholesterol, high-density lipoprotein cholesterol, triglycerides, and fasting glucose levels were determined by a colorimetric enzymatic method (Siemens Advia 1650, Deerfield, USA). Low-density lipoprotein cholesterol was estimated indirectly by the Friedewald formula [28 (link)]. Total testosterone levels (reference values 0.14–0.76 ng/mL) were measured by chemiluminescence immunoassay (Siemens Advia Centaur XP) with a sensitivity of 0.10 ng/mL and intra- and inter-assay CVs of 3.3% and 7.5%, respectively. Plasma insulin and SHBG levels were measured by chemiluminescence immunoassay (Siemens Advia Centaur XP) with a sensitivity of 0.50 μIU/mL and 0.035 nmol/L, respectively, an intra-assay CV of < 3%, and an inter-assay CV of < 5%. Creatinine levels were determined by the Jaffe reaction without deproteinization. Progesterone levels were determined by electrochemiluminescence immunoassay (CentraLink).

Fighera T.M., dos Santos B.R, & Spritzer P.M. (2023). Lean mass and associated factors in women with PCOS with different phenotypes. PLOS ONE, 18(10), e0292623.

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Anthropometric and Biochemical Evaluation in AI

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All patients with AI and controls underwent anthropometric measurements and biochemical screening. The waist/hip ratio and body mass index (BMI) were calculated. Fasting blood samples were obtained in the morning between 08:00 and 11:00 hours. Serum high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides levels by spectrophotometric assay (Advia 2400, Siemens Healthcare Diagnostics Inc., Tarrytown USA). The fasting serum insulin level was measured using the chemiluminescent immunoassay method (Advia Centaur XP, Siemens Healthcare Diagnostics Inc., Tarrytown, USA). The estimate of insulin resistance was calculated using the HOMA-IR index. TSH, fT3 and fT4 were measured via chemiluminescent microparticle immunoassay (Abbott, Architect i2000, Abbott Laboratories Diagnostics Division, IL, USA). Anti-thyroglobulin antibody (anti-Tg Ab) and anti-thyroperoxidase antibody (anti-TPO Ab) were measured via chemiluminescent competitive immunoassay (Siemens, Advia Centaur XP). Reference limits were as follows: fT3: 1.71-3.71 pg/ mL; fT4: 0.7-1.48 ng/dL, TSH: 0.35-4.94 µIU/mL, anti-Tg Ab: 0-60 U/mL, anti-TPO Ab: 0-57 U/mL. Anti-Tg Ab and anti-TPO Ab concentrations > 60 IU/mL and > 57 IU/mL, respectively, were considered positive.

Karakose M., Karbek B., Sahin M., Arslan M.S., Topaloglu O., Erden G., Demirci T., Calıskan M, & Delibasi T. (2015). The association of autoimmune thyroiditis and non-functional adrenal incidentalomas with insulin resistance. Archives of endocrinology and metabolism, 59(1).

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Piglet Blood Biochemical Profiling

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Piglets were bled (10 animals from each group) from the jugular vein into vacuum blood tubes (BD Vacutiner, United Kingdom) before the morning feeding. Tubes with clot activator were used for biochemical examination. Blood biochemical variables were evaluated before and after the experiment (on days 25 and 61 of the piglets' life). The following parameters were included: aspartate aminotransferase (AST), cholesterol (mmol), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL) cholesterol, triglycerides (TG), phosphorus (IP), magnesium (Mg), potassium (K), sodium (Na), triiodothyronine (T3), thyroxine (T4), immunoglobulin IgG, vitamin B12, alanine aminotransferase (ALT), albumin (ALB), total protein (TP), iron (Fe), glucose (GLU), calcium (Ca), creatinine analyzed by the Jaffe method (CREA), alkaline phosphatase (AP), and urea. They were analyzed with an automatic biochemistry analyzer “SIEMENS ADVIA 1800” (Siemens Healthcare GmbH, Germany) and immunochemical analyses [triiodothyronine (T3) and thyroxine (T4)] by analyzer “SIEMENS ADVIA Centaur XP” (Siemens Healthcare GmbH, Germany) in the accredited laboratory “Anteja” (Klaipeda, Lithuania).

Vadopalas L., Ruzauskas M., Lele V., Starkute V., Zavistanaviciute P., Zokaityte E., Bartkevics V., Pugajeva I., Reinolds I., Badaras S., Klupsaite D., Mozuriene E., Dauksiene A., Gruzauskas R, & Bartkiene E. (2020). Combination of Antimicrobial Starters for Feed Fermentation: Influence on Piglet Feces Microbiota and Health and Growth Performance, Including Mycotoxin Biotransformation in vivo. Frontiers in Veterinary Science, 7, 528990.

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