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Bupivacaine

Manufactured by Henry Schein
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Bupivacaine is a local anesthetic agent used in medical procedures. It is a type of amide-linked local anesthetic that can be used to provide pain relief in various clinical settings. The core function of Bupivacaine is to temporarily block the transmission of pain signals from the affected area to the brain, allowing for pain management during medical treatments.

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Lab products found in correlation

Buprenex, by Henry Schein (1 mentions) Carprofen, by Merck Group (1 mentions) Isoflurane, by Phoenix Pharmaceuticals (1 mentions)

2 protocols using bupivacaine

1

Animal Surgery and Tumor Monitoring Protocols

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All animal procedures were approved by the Rutgers University Institutional Animal Care and Use Committee according to NIH guidelines. All surgery was performed under isoflurane gas and all efforts were made to minimize suffering. During surgery, animals were given Bupivacaine (Henry Schein; Dublin, OH) as a local anesthetic. Post-operative care included local administration of Buprenex (Henry Schein) as a local analgesic followed by daily monitoring for two weeks. For tumor development studies, animals were sacrificed if their tumor volume (as measured by S2 * L/2 where S and L are the shortest and longest diameter in mm, respectively) exceeded 10% of body weight or the mean tumor diameter exceeded 40 mm.
Stires H., Saboya M., Globerman S.P, & Cohick W.S. (2016). Peroral Estradiol Is Sufficient to Induce Carcinogen-Induced Mammary Tumorigenesis in Ovariectomized Rats without Progesterone. PLoS ONE, 11(9), e0162662.
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2

Ovariectomy and Sumatriptan in Rats

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Ovariectomy was performed on female rats at 3–4 weeks (21–28 days) of age (i.e. before puberty). Under isoflurane (2.5%) inhalation anesthesia (Phoenix Pharmaceuticals, St. Joseph, MO, USA) in 97.5% O2, six female rats were treated with 0.5% of bupivacaine (from Henry Schein, Melville, NY, USA) at their surgical incision site and an intramuscular injection of a non-steroidal anti-inflammatory, carprofen [5 mg/kg; Sigma-Aldrich (St. Louis, MO, USA)], followed by removal of the ovaries through bilateral upper flank incisions (Joseph and Levine, 2003b (link), a (link)). The ovarian bundles were tied off with 4-0 silk sutures and the ovaries excised. The fascia and skin were closed with 5-0 silk suture. Five weeks after the surgery sumatriptan (1 ng) was injected intradermally on the dorsum of the hindpaw.
Araldi D., Ferrari L.F., Green P, & Levine J.D. (2016). Marked Sexual Dimorphism in 5-HT1 Receptors Mediating Pronociceptive Effects of Sumatriptan. Neuroscience, 344, 394-405.
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