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Dynamic hybrid rheometer dhr 3

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The Dynamic Hybrid Rheometer (DHR-3) is a versatile instrument designed to measure the rheological properties of a wide range of materials. It is capable of performing various rheological measurements, including shear, extensional, and oscillatory tests, to characterize the flow and deformation behavior of samples.

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DHR-3 rheometer (86 citations) DHR-3 (56 citations) DHR-3 Hybrid Rheometer (2 citations)

2 protocols using dynamic hybrid rheometer dhr 3

1

Unconfined Compression of 3D Collagen Matrices

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Unconfined compression of 3D organotypic collagen matrices treated with or without PXS-5505 was performed on a TA Instruments Dynamic Hybrid Rheometer (DHR-3, TA Instruments). Remodeled collagen matrices were placed between upper and lower parallel plate geometries. A constant linear compressive rate of 5 µm s−1 was applied to the samples and axial force (N) and gap (mm) were collected every 0.01 s. Data were processed and a stress–strain curve for each replicate was obtained. Bulk elastic modulus (kPa) was obtained as the gradient of the linear region of the stress–strain curve corrected for cross-sectional area of sample and normalized to control. Data points represent biological replicates. No statistical methods were used to predetermine sample sizes but our sample sizes are similar to those reported in previous publications34 (link).
Chitty J.L., Yam M., Perryman L., Parker A.L., Skhinas J.N., Setargew Y.F., Mok E.T., Tran E., Grant R.D., Latham S.L., Pereira B.A., Ritchie S.C., Murphy K.J., Trpceski M., Findlay A.D., Melenec P., Filipe E.C., Nadalini A., Velayuthar S., Major G., Wyllie K., Papanicolaou M., Ratnaseelan S., Phillips P.A., Sharbeen G., Youkhana J., Russo A., Blackwell A., Hastings J.F., Lucas M.C., Chambers C.R., Reed D.A., Stoehr J., Vennin C., Pidsley R., Zaratzian A., Da Silva A.M., Tayao M., Charlton B., Herrmann D., Nobis M., Clark S.J., Biankin A.V., Johns A.L., Croucher D.R., Nagrial A., Gill A.J., Grimmond S.M., Pajic M., Timpson P., Jarolimek W, & Cox T.R. (2023). A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer. Nature Cancer, 4(9), 1326-1344.
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2

Unconfined Compression Analysis of Tissue

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Unconfined compression of in vivo tissue samples was carried out on 2–3-mm cross-sectional slices using a TA Instruments Dynamic Hybrid Rheometer (DHR-3, TA Instruments). Tissue samples were placed between upper and lower parallel plate geometries. A constant linear compressive rate of 5 µm s−1 was applied to the samples and axial force (N) and gap (mm) were collected every 0.01 s. Data were processed and a stress–strain curve for each replicate was obtained. Bulk elastic modulus (kPa) was obtained as the gradient of the linear region of the stress–strain curve corrected for cross-sectional area of sample. Data points represent individual biological replicates.
Chitty J.L., Yam M., Perryman L., Parker A.L., Skhinas J.N., Setargew Y.F., Mok E.T., Tran E., Grant R.D., Latham S.L., Pereira B.A., Ritchie S.C., Murphy K.J., Trpceski M., Findlay A.D., Melenec P., Filipe E.C., Nadalini A., Velayuthar S., Major G., Wyllie K., Papanicolaou M., Ratnaseelan S., Phillips P.A., Sharbeen G., Youkhana J., Russo A., Blackwell A., Hastings J.F., Lucas M.C., Chambers C.R., Reed D.A., Stoehr J., Vennin C., Pidsley R., Zaratzian A., Da Silva A.M., Tayao M., Charlton B., Herrmann D., Nobis M., Clark S.J., Biankin A.V., Johns A.L., Croucher D.R., Nagrial A., Gill A.J., Grimmond S.M., Pajic M., Timpson P., Jarolimek W, & Cox T.R. (2023). A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer. Nature Cancer, 4(9), 1326-1344.
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