Discovery 3t ge mr750

Manufactured by GE Healthcare

Sourced in United States

The Discovery 3T GE-MR750 is a 3 Tesla magnetic resonance imaging (MRI) system designed for clinical use. It features a superconducting magnet and provides high-quality image acquisition capabilities. The system is intended for general diagnostic imaging purposes.

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Lab products found in correlation

32 channel head coil, by Siemens (1 mentions) Prisma scanner, by Siemens (1 mentions) Gadovist, by Bayer (1 mentions)

Close spelling variants of this product

GE 3T Discovery MR750 scanner 3T Discovery MR750 GE Discovery MR750 GE MR750 Discovery MR750 3T Discovery MR750

11 protocols using discovery 3t ge mr750

Multimodal MRI Investigation of Healthy Females

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Magnetic resonance imaging data was acquired on a 3-Tesla MRI medical scanner (Discovery 3T GE-MR750, General Electric, Milwaukee, Wisconsin) equipped with a 32-channel and 8-channel phased array receiving coil. The 32-channel coil was used for all the sequences; The 8-channel coil was used, in addition, for acquisition of the 3D T1 images (see further) as we found signal inhomogeniety at the frontal and occipital poles when employing the 32-channel coil, not present when using the 8-channel col. The 32-channel coil was preferable for acquisition of the fMRI data. ALL the subjects were investigated with identical protocols. 3D T1-weighted spoiled gradient (SPGR) images were acquired with 1 mm3 isotropic voxel size (TE = 3.1ms, TR = 7.9ms, TI = 450ms, FoV = 24cm, 176 axial slices, flip angle of 12 deg.). MR sequences included resting state functional MRI, (closed eyes, 10 minutes) performed with a gradient echo pulse sequence using a voxel size of 3x3 mm, (TE = 30ms, TR = 2500ms, FoV = 28.8cm, 44 interleaved axial slices, 3mm thickness, flip angle of 90 deg.). Finally, there was a clinical sagital FLAIR: TE/TR = 117/8000, TI = 2255, ETL = 140, ARC acceler. R = 2 x 2 (slice, phase), FoV: 27cm, 224x224, slice thickness, 1.2 mm.
The female controls were tested day 10–14 of the menstrual cycle (all had regular 4 weeks cycles).

Manzouri A, & Savic I. (2018). Multimodal MRI suggests that male homosexuality may be linked to cerebral midline structures. PLoS ONE, 13(10), e0203189.

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Multimodal Neuroimaging Acquisition Protocol

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MRI data was acquired on a 3 Tesla MRI scanner (Discovery 3T GE-MR750, General Electric, Milwaukee, Wisconsin) using a 32-channel head coil. Resting-state functional MRI data were acquired with a gradient echo pulse sequence with: voxel size of 2.25 × 2.25 × 3 mm, TR/TE = 2500/30 ms, FOV = 28.8 cm, 45 interleaved axial slices, 90 flip angle. Each resting-state scan totaled 7 min 35 s and participants were instructed to rest with eyes closed, to remain as still as possible, and not to sleep while the sequence was acquired. Structural data, 3D T1-weighted Spoiled Gradient Echo pulse sequence, were acquired with voxel size 0.94 × 0.94 × 1 mm, TR/TE = 7.91/3.06 ms, TI = 450 ms, FOV = 24 cm, 176 axial slices, and 12 flip angle.

Moody T.D., Feusner J.D., Reggente N., Vanhoecke J., Holmberg M., Manzouri A., Sorouri Khorashad B, & Savic I. (2020). Predicting outcomes of cross-sex hormone therapy in transgender individuals with gender incongruence based on pre-therapy resting-state brain connectivity. NeuroImage : Clinical, 29, 102517.

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Harmonizing MRI Data Acquisition Parameters

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In Stockholm, magnetic resonance imaging (MRI) data were acquired on a 3-Tesla MRI scanner (Discovery 3 T GE-MR750, General Electric, Milwaukee, WI) equipped with an 8-channel phased array receiving coil. T1-weighted images were acquired with a Spoiled Gradient Echo Pulse (SPGR) sequence with following parameters: 1 mm isotropic voxel size; TR = 7.9 ms; TE = 3.1 ms; FoV = 23 cm; flip angle = 12°. In Los Angeles, MRI data were acquired on a 3-Tesla Siemens Prisma scanner with a 32-channel head coil. T1-weighted images were acquired with a Magnetization Prepared Rapid Acquisition Gradient Echo (MPRAGE) sequence with the following parameters: 1 mm isotropic voxel size; distribution factor 50%; TR = 1900 ms; TE = 3.26 ms; flip angle = 9°. Before initiation of this collaborative study, we carefully harmonized data acquisition parameters to minimize effects of scanner difference.

Khorashad B.S., Wang Y., Holmberg M., Dhejne C, & Savic I. (2024). Gender Incongruence and Autistic Traits: Cerebral and Behavioral Underpinnings. Archives of Sexual Behavior, 53(5), 1873-1884.

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Structural and Diffusion MRI Protocol

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Magnetic resonance imaging data was acquired on a 3-Tesla MRI scanner (Discovery 3 T GE-MR750, General Electric, Milwaukee, Wisconsin) equipped with a 32-channel/or 8-channel phased array receiving coil. 3D T1-weighted Spoiled Gradient Echo pulse sequence (SPGR) images were acquired with 1 mm³ isotropic voxel size (TE = 3.1 ms, TR = 7.9 ms, TI = 450 ms, FoV = 24 cm, 176 axial slices, flip angle 12 deg.). Multi-slice diffusion-weighted imaging was performed using an echo planar imaging sequence with 1 × 1 mm in-plane resolution, [TE = 83 ms, TR 8000 ms, FoV = 24 cm, 60 interleaved axial slices, thickness = 2.9 mm, 60 diffusion gradient directions (b = 1000)]. For the diffusion sequences we used a 32-channel phased array receiving coil, and for the T1 sequence we used an 8-channel coil because it provided better demarcations between white and grey matter in the occipital cortex for the purposes of the Freesurfer analyses (http://freesurfer.net/) used for calculation of ICVs.

Burke S.M., Manzouri A.H, & Savic I. (2017). Structural connections in the brain in relation to gender identity and sexual orientation. Scientific Reports, 7, 17954.

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Structural MRI Protocol for Cortical Analysis

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MRI data were acquired on a 3-Tesla MRI scanner (Discovery 3T GE-MR750, General Electric, Milwaukee, Wisconsin), equipped with a 32-channel or 8-channel phased array receiving coil. 3D T1-weighted Spoiled Gradient Echo pulse sequence (SPGR) images were acquired with 1 mm3 isotropic voxel size (TE = 3.1 ms, TR = 7.9 ms, TI = 450 ms, FoV = 24 cm, 176 axial slices, flip angle 12°). We used an 8-channel coil because it provided better demarcations between white and grey matter in the occipital cortex for the purposes of the FreeSurfer analyses.

Kilpatrick L.A., Holmberg M., Manzouri A, & Savic I. (2019). Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls. The European journal of neuroscience, 50(8), 3269-3281.

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High-Resolution 3D MRI Brain Imaging

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3D T1-weighted SPGR (spoiled gradient echo; TE = 3.1 ms, TR = 7.9 ms, TI = 450 ms, FOV = 24 cm, matrix = 240×240, 176 axial slices, flip angle = 12 degree) were acquired with 1 mm³ isotropic resolution using a 3-Tesla MRI medical scanner (Discovery 3T GE-MR750, General Electric, Milwaukee, Wisconsin) equipped with an 8-channel phased array receiving coil.

Abé C., Johansson E., Allzén E, & Savic I. (2014). Sexual Orientation Related Differences in Cortical Thickness in Male Individuals. PLoS ONE, 9(12), e114721.

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Multimodal Neuroimaging Acquisition Protocol

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Magnetic resonance imaging data was acquired on a 3 Tesla MRI scanner (Discovery 3 T GE‐MR750, General Electric, Milwaukee, WI). Functional MRI of both the body perception and body localizer tasks was performed with a gradient echo pulse sequence using a voxel size of 3.03 × 3.03 × 3.5 mm (TE = 30 ms, TR = 2000 ms, FoV = 23 cm, 41 bottom up interleaved axial slices, 3 mm thickness, 75° flip angle) and a 32‐channel head coil. 3D T1‐weighted Spoiled Gradient Echo pulse sequence (SPGR) images were acquired with 1 mm³ isotropic voxel size (TE = 3.1 ms, TR = 7.9 ms, TI = 450 ms, FoV = 23 cm, 176 axial slices, 12° flip angle) using an 8‐channel coil.

Burke S.M., Majid D.S., Manzouri A.H., Moody T., Feusner J.D, & Savic I. (2018). Sex differences in own and other body perception. Human Brain Mapping, 40(2), 474-488.

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Multimodal Brain Imaging Protocol

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This acquisition of MRI data has been detailed elsewhere^{25 (link)} and will be reviewed here too. The images were acquired on a 3-T MRI scanner (Discovery 3 T GE-MR750, General Electric) equipped with a 32-channel phased array receiving coil for all the sequences. 3D T1-weighted Spoiled Gradient Echo pulse sequence (SPGR) images were acquired with 1 mm 3 isotropic voxel size (time echo [TE] = 3.1 ms, time repetition [TR] = 7.9 ms, time to inversion [TI] = 450 ms, field of view = 24 cm, 176 axial slices, flip angle 12°). Resting-state functional MRI (fMRI) was performed with a gradient echo pulse sequence using a voxel size of 2.25 × 2.25 × 3 mm (TE = 30 ms, TR = 2500 ms, FoV = 28.8 cm, 45 bottom-up interleaved axial slices, 3 mm thickness, flip angle 90°). During the fMRI session, which lasted 8 min, participants were instructed to close their eyes, not to try to solve any special task but just “let the mind wander,” and to try not to fall asleep.

Khorashad B.S., Manzouri A., Feusner J.D, & Savic I. (2021). Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles. Scientific Reports, 11, 2799.

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MRI Evaluation of Brain Metastases

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Routine MRI scans for evaluating BMs were performed using a GE 3T Discovery MR750 (GE Healthcare, Milwaukee, WI, USA) scanner. The brain MRI protocol used in this study included three-dimensional (3D) T1-weighted imaging, T2-weighted imaging, fluid-attenuated inversion recovery, SWAN, and subsequent contrast-enhanced 3D T1-weighted imaging. The sequence parameters for SWAN were as follows: repetition time (TR) = 31 ms, echo time (TE) = 3 echoes centered around 23 ms, flip angle = 10°, slice thickness = 2 mm, intersection gap = 0 mm, field of view = 210 mm, matrix number = 320 × 224, and bandwidth = 62.50 kHz (Figure 2).
Two radiologists, who were blinded to the clinical and histopathologic findings, independently evaluated the MR images on the picture archiving and communication system workstation monitors for the following characteristics: number of metastatic lesions, size of the metastatic lesions, and presence of intratumoral hemorrhage. The lesion size was defined as the lesion’s largest dimension in any plane on the MR image. Intratumoral hemorrhage was considered to be present if the lesion contained dark signals on the phase map of SWAN [20 (link)]. All disagreements were resolved by consensus.

Kim S.S., Lee S., Park M., Joo B., Suh S.H, & Ahn S.J. (2023). Associated Factors of Spontaneous Hemorrhage in Brain Metastases in Patients with Lung Adenocarcinoma. Cancers, 15(3), 619.

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MRI-based Fat Fraction Mapping

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Subjects underwent an MRI examination in supine position with a 3-T scanner (GE 3T Discovery MR750; GE Healthcare, Waukesha, WI, USA) using an eight-channel phased-array spine coil. A T1-weighted fast spin-echo (FSE) sequence (axial plane) and an iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL) sequence (axial plane) were used for this study (Table 1).
The IDEAL sequence is a commonly used CSE-MRI technique that provides robust and homogenous water–fat separation. It was processed using the vendor’s routines, including phase error correction and a complex-based water–fat decomposition considering a pre-calibrated six-peak fat spectrum and a single T2*. Axial FF maps were generated from pixel-wise calculation of the ratio of the fat signal over the sum of fat and water signals.

Sollmann N., Bonnheim N.B., Joseph G.B., Chachad R., Zhou J., Akkaya Z., Pirmoazen A.M., Bailey J.F., Guo X., Lazar A.A., Link T.M., Fields A.J, & Krug R. (2022). Paraspinal Muscle in Chronic Low Back Pain: Comparison Between Standard Parameters and Chemical Shift Encoding-Based Water–Fat MRI. Journal of magnetic resonance imaging : JMRI, 56(5), 1600-1608.

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