The study protocol was approved by the Cambridgeshire Research and Ethics Committee (Ref. 07/H0306/123) and consent obtained from relatives. Arteries were harvested from human hearts during autopsy in consultation with a senior pathologist. Hearts were excluded if coronary artery thrombosis was the suspected cause of death. All vessels were stored immediately in phosphate-buffered saline at 4°C and imaged within 48 hours of death. The left anterior descending artery (n=14) was dissected and excised, including ≈40 mm of surrounding tissue to maintain overall structural integrity.4 (link) Side branches were ligated and a guide catheter sutured into the left coronary ostium. A 0.014″ coronary guidewire (either BMW Universal or Pilot 50, Abbott Vascular) was advanced permitting delivery of intravascular catheters. The vessel was fixed to a proprietary designed rig and prewarmed (to 37°C). Vessels were imaged under pressure–perfusion at 100 mm Hg before histological processing. VH-IVUS data were acquired using 20-MHz Eagle-Eye Gold catheters (Volcano Corporation) at 0.5 mm/s pullback, with radiofrequency data being captured on the R wave provided by an ECG signal generator. OCT data were acquired by DragonFly C7 catheters (St. Jude Medical) using 25.0 mm/s automated pullback. All imaging data were digitally stored and exported for offline analysis.
Dragonfly c7 catheters
Manufactured by Abbott
Sourced in United States
The DragonFly C7 catheters are a line of medical devices designed for use in diagnostic and interventional procedures. The catheters are intended to provide access and facilitate the introduction of other instruments or materials into the vascular system.
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Lab products found in correlation
3 protocols using dragonfly c7 catheters
1
Imaging of Human Coronary Arteries
2
Plaque Rupture Identification via Multimodal Imaging
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IVUS-VH data were acquired with 20-MHz Eagle-Eye catheters (Volcano Corporation, Rancho, Cordova) using motorized pullback at 0.5 mm/s. OCT data were acquired with Dragonfly C7 catheters (St. Jude Medical, St. Paul, Minnesota) using an automated pullback at 20 mm/s. Plaque classification, identification of rupture (Figure 2 ) and characterization of rupture location along the plaque length (Online Figure 1 ) were performed as previously described (Online Appendix ). IVUS-VH plaque frames that demonstrated ruptures were not included in the final analysis for ruptured plaques, unless otherwise stated, because the extreme luminal eccentricity resulting from rupture at these frames would make PSS calculations unreliable.![]()
Identification of Plaque Rupture Using Gray-Scale Intravascular Ultrasound and Optical Coherence Tomography
3
Postmortem Human Coronary Artery Imaging
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