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Dicalcium phosphate

Manufactured by Merck Group
Sourced in United States, Germany, India

Dicalcium phosphate is a chemical compound commonly used as a dietary supplement and in various industrial applications. It is a colorless, odorless, and tasteless crystalline powder. The core function of dicalcium phosphate is to provide a source of calcium and phosphorus, two essential minerals required for various bodily functions.

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3 protocols using dicalcium phosphate

1

Telmisartan Solid Dispersion Formulation

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Telmisartan, D-mannitol, meglumine, and magnesium stearate were received from Jeil Pharmaceutical Co., Ltd. (Seoul, Korea). Polyvinylpyrrolidone (PVP K25) and crospovidone (Kollidon®® CL-F) were obtained from BASF AG (Ludwigshafen, Germany). Dicalcium phosphate and sodium hydroxide were obtained from Sigma-Aldrich Co. (St. Louis, MO, USA). Microcrystalline cellulose (MCC 101) was obtained from DFE Pharma (Dusseldorf, Germany). F-MELT®® (Type C) was obtained from Fuji Chemical Industries Co., Ltd. (Toyama, Japan). All other reagents were of analytical or HPLC grade and were used as received.
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2

Octacalcium Phosphate-Induced Osteoarthritis

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Octacalcium phosphate crystals
(OCP), a type of basic calcium phosphate (BCP) often deposited in
joints, causing acute inflammatory arthritis and joint degeneration,29 (link) were used to induce OA in this study. OCP precipitate
was collected from dicalcium phosphate (Sigma-Aldrich, Darmstadt,
Germany) and 0.05 M diammonium phosphate solution (Sigma-Aldrich,
Darmstadt, Germany) according to a previous study.30 (link) The OCP powder collected after precipitation was washed
with distilled water and dried at 37 °C. Pterostilbene (PT) with
a purity of 98% was purchased from Combi Blocks (San Diego, USA).
LPS and ATP were purchased from Sigma-Aldrich (Darmstadt, Germany).
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3

Telmisartan-based Formulation Development

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Telmisartan was gifted from Octavius, India. Cinnamon oil and lactose LR were obtained from S.D. Fine chemicals, India. PEG 400, Pluronic F 127, Dicalcium Phosphate and MCC were obtained from Sigma Aldrich, India.
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