Pmod fusion tool v3

To calculate SUVR values of arrow-indicated areas and contralateral areas at temporal lobe, the volume of interests (VOIs) were manually defined on the basis of the anatomically symmetrical coordinates. The VOIs consisted of 10 × 10 × 10 mm that were placed in fusiform gyrus (FG), middle temporal gyrus (MTG), hippocampus (HIP) and inferior temporal gyrus (ITG) using the PMOD Fusion tool v3.7 (PMOD Technologies). We calculated SUVR values and quantified values of the ratio of arrow-indicated areas to contralateral areas.

MEG was recorded with simultaneous scalp-EEG for 40-min periods during awake and sleep conditions using a 1000 Hz sampling rate and band-pass filter between 0.03 and 330 Hz, with a whole-head system that consisted of 204 planar gradiometers (Elekta, Helsinki, Finland). The location of the dipole sources that best fit the measured magnetic fields was calculated using a single ECD model at the peak of each spike. We selected and presented ECDs that showed >90% goodness-of-fit value for the evaluation. The estimated ECDs were plotted on the co-registered [¹¹C]K-2 images using the PMOD Fusion tool v3.7 (PMOD Technologies). We qualitatively evaluated the locational relationship between the estimated ECDs and brain areas with high [¹¹C]K-2 uptake.