Signa system

Manufactured by GE Healthcare

Sourced in United States

The Signa System is a magnetic resonance imaging (MRI) device developed by GE Healthcare. It is designed to capture high-quality images of the body's internal structures and functions. The system utilizes powerful magnets and radio waves to generate detailed, cross-sectional images that can be used for diagnostic and monitoring purposes. The core function of the Signa System is to provide healthcare professionals with the necessary imaging capabilities to support their medical practices.

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Lab products found in correlation

Skyra system, by Siemens (2 mentions) Magnetom avanto system, by Siemens (1 mentions) Quadrature sending and receiving head coil, by GE Healthcare (1 mentions)

Close spelling variants of this product

Signa LX Echospeed System Signa MRI system Signa Horizon LX Echospeed system Signa PET/MRI 3 Tesla system Signa Excite 1.5 T MR imaging system Signa MR system Signa Excite HD 3.0 T System Signa ExciteHD system GE Signa Imaging system GE Signa MRI system

36 protocols using signa system

Optimized fMRI Acquisition and Analysis

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FMRI scanning was performed on a 3T GE Signa System (General Electric; Milwaukee, WI) using a standard radiofrequency coil at the University of Michigan Functional MRI Laboratory. Whole-brain functional images (i.e., blood oxygen level–dependent [BOLD]) were collected from 43 axial, 3-mm-thick slices using a T2*-sensitive gradient echo reverse spiral acquisition sequence (repetition time, 2,000 ms; echo time, 30 ms; 64 × 64 matrix; 220 mm field of view; flip angle, 90°), optimized to minimize susceptibility artifacts (signal loss) at the medial temporal lobe (including the amygdala).^{51 (link)} The first 4 volumes from each run were discarded to allow magnetization to reach equilibrium.
Functional images were processed and analyzed using Statistical Parametric Mapping software (SPM8, Wellcome Trust Center for Neuroimaging, University College London, London, UK; www.fil.ion.ucl.ac.uk/spm). Images were temporally corrected to account for slice time acquisition differences and spatially realigned to the first image of the first run to correct for head movement; motion parameters were entered as regressors of no-interest to control for head movement during scanning. Images were normalized to a Montreal Neurological Institute (MNI) template using the echo-planar imaging (EPI) template, resampled to 2 mm^{3 (link)} voxels and smoothed with an 8 mm isotropic Gaussian kernel.

Fitzgerald J.M., MacNamara A., Kennedy A.E., Rabinak C.A., Rauch S.A., Liberzon I, & Phan K.L. (2016). Individual Differences in Cognitive Reappraisal Use and Emotion Regulatory Brain Function in Combat-Exposed Veterans with and without PTSD. Depression and anxiety, 34(1), 79-88.

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BOLD-Sensitive Whole-Brain fMRI Acquisition

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Scanning was conducted on a 3 Tesla GE Signa System (General Electric; Milwaukee, WI) and performed with blood oxygen-level dependent (BOLD)-sensitive whole-brain fMRI. Images were acquired using a gradient-echo echo-planar imaging sequence with the following parameters: TR = 2s, TE = 25 ms, flip angle = 90°, field of view = 22 x 22 cm², acquisition matrix 64 x 64; 44 axial, 3-mm-thick slices with no gap. For anatomical localization, a high-resolution, T1-weighted volumetric anatomical scan was acquired.
Data from all participants met criteria for quality with minimal motion correction (movements were <3 mm and <3 degrees rotation in any one direction) and the first 4 volumes from each run were discarded to allow for T1 equilibration effects. Conventional preprocessing steps were used in the Statistical Parametric Mapping (SPM8) software package (Wellcome Trust Centre for Neuroimaging, London www.fil.ion.ucl.ac.uk/spm). Briefly, images were temporally corrected to account for differences in slice time collection, spatially realigned to the first image of the first run, normalized to a Montreal Neurological Institute (MNI) template, resampled to 2 x 2 x 2 mm voxels, and smoothed with an 8mm isotropic Gaussian kernel.

Klumpp H., Roberts J., Kapella M.C., Kennedy A.E., Kumar A, & Phan K.L. (2017). Subjective and Objective Sleep Quality Modulate Emotion Regulatory Brain Function in Anxiety and Depression. Depression and anxiety, 34(7), 651-660.

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MRI Imaging with 3T Scanner

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MR imaging was performed with a 3T scanner (Signa system with Excite 14.0; General Electric, Milwaukee, WI).

Radmanesh A., Zamani A.A., Whalen S., Tie Y., Suarez R.O, & Golby A.J. (2014). Comparison of Seeding Methods for Visualization of the Corticospinal Tracts Using Single Tensor Tractography. Clinical neurology and neurosurgery, 0, 44-49.

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Multimodal MRI Cerebral Blood Flow Assessment

Cited 3 times

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All scans were acquired on a 1.5-Tesla Signa system (General Electrics (GE), Waukesha, WI). In the first session when subjects were at rest, imaging with pCASL was followed with phase contrast (PC)-MRI for quantification of total CBF (tCBF). Anatomical imaging was acquired for brain tissue segmentation. The pCASL imaging was performed with the product sequence from GE [14 (link)], which adheres almost completely to the recently internationally recommended implementation of ASL [6 (link)]; a 3D fast spin echo (FSE) using spiral acquisition and background suppression with a scan time of 5 minutes (TR ⁄TE = 4678 ⁄ 9.8 msec, labeling duration 1500 msec, post labeling delay 1525 msec, 512 sampling points on eight spirals; reconstructed matrix 128x128, three averages, slice thickness 4 mm, FOV 24 cm). A PC-MRI scan (TR ⁄TE = 20⁄6.2 msec; flip-angle, 9°; FOV, 22 cm; matrix, 256x256; slice thickness 5 mm; velocity encoding 100 cm/sec) for measuring mean tCBF was prescribed on a PC-MRI sagittal localizer image perpendicular to the carotid arteries at the level of the mid basilar artery (Fig 1). The anatomical image protocol has been described in detail elsewhere [15 (link)] and included T1-weighted 3D spoiled gradient echo, proton density/T2-weighted FSE and fluid attenuated inversion recovery (FLAIR) sequences.

Sigurdsson S., Forsberg L., Aspelund T., van der Geest R.J., van Buchem M.A., Launer L.J., Gudnason V, & van Osch M.J. (2015). Feasibility of Using Pseudo-Continuous Arterial Spin Labeling Perfusion in a Geriatric Population at 1.5 Tesla. PLoS ONE, 10(12), e0144743.

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Standardized Structural MRI Protocol

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Scanning was performed at the IoPPN, London, and Addenbrooke's Hospital, Cambridge, using a 3 T GE Signa System (General Electric). A specialized acquisition protocol using quantitative T1‐mapping was used to ensure standardization of structural magnetic resonance imaging (MRI) scans across scanner platforms. This protocol has previously been validated and extensively described elsewhere (Deoni et al., 2008; Ecker et al., 2012), resulting in high‐resolution structural T1‐weighted inversion‐recovery images, with 1 × 1 × 1 mm resolution, a 256 × 256 × 176 matrix, TR = 1800 ms, TI = 850 ms, FA = 20°, and FOV = 25.6 cm. These images were subsequently used for surface reconstruction.

Mann C., Schäfer T., Bletsch A., Gudbrandsen M., Daly E., Suckling J., Bullmore E.T., Lombardo M.V., Lai M., Craig M.C., Baron‐Cohen S., Murphy D.G, & Ecker C. (2020). Examining volumetric gradients based on the frustum surface ratio in the brain in autism spectrum disorder. Human Brain Mapping, 42(4), 953-966.

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High-Resolution MRI Protocol for Brain Imaging

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MRI scanning was performed at the Brigham and Women’s Hospital in Boston, MA with a 3 Tesla General Electric Signa System (GE Medical Systems). High spatial resolution MR sequences included 3D T1-weighted [inversion recovery spoiled gradient recalled (SPGR)], 3D T2-weighted (CUBE), and diffusion acquisitions. The IR-SPGR sequence had a repetition time (TR) of 7.8 ms, an echo time (TE) of 3 ms, an inversion time of 600 ms, a 10° flip angle, a field of view (FOV) of 256 × 256 mm, a matrix size of 256 × 256, 176 slices, and 1 mm slice thickness. The 3D T2-weighted sequence had a TR of 3 s, a TE of 90 ms, a 90° flip angle, a FOV of 256 × 256 mm, a matrix size of 256 × 256, 176 slices, and 1 mm slice thickness. The high-resolution diffusion acquisition was twice refocused and had a TR of 17 s, TE 78 ms, a 90° flip angle, a FOV of 240 × 240 mm, a matrix size of 144 × 144, 85 slices, 1.7 mm slice thickness, 51 gradient directions with a b-value of 900 s/ mm2, and eight additional non-diffusion-weighted (b0) images. We used the proprietary GE DTI sequence, which on a 3 T GE scanner minimizes TE for each subject.

del Re E.C., Bouix S., Fitzsimmons J., Blokland G.A., Mesholam-Gately R., Wojcik J., Kikinis Z., Kubicki M., Petryshen T., Pasternak O., Shenton M.E, & Niznikiewicz M. (2019). Diffusion abnormalities in the corpus callosum in first episode schizophrenia: Associated with enlarged lateral ventricles and symptomatology. Psychiatry research, 277, 45-51.

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Neuroanatomical Correlates of Impulsivity

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Data from 88 healthy male participants was included in this replication study (Table 1). Specifically, structural T1-weighted images and self-report measures of trait impulsivity data were pooled from various PET studies [35 (link)–38 (link)]. All studies, and their design, were approved by the Regional Ethics Committee in Stockholm and the Karolinska University Hospital Radiation Safety Committee. All subjects gave written informed consent prior to participating according to the Helsinki declaration.
Structural data for 76 subjects was acquired on a 1.5 T GE Signa system (Milwaukee, WI) (hereafter termed Scanner 1) and for 12 subjects on a 1.5T Siemens Magnetom Avanto system (Erlangen, Germany) (hereafter termed Scanner 2). Exclusion criteria for all subjects included historical or present episode of psychiatric illness, alcohol or drug abuse, major somatic illness, or habitual use of nicotine as determined by a physical and psychiatric examination by a physician.

Caravaggio F., Plavén-Sigray P., Matheson G.J., Plitman E., Chakravarty M.M., Borg J., Graff-Guerrero A, & Cervenka S. (2018). Trait impulsivity is not related to post-commissural putamen volumes: A replication study in healthy men. PLoS ONE, 13(12), e0209584.

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High-Resolution Structural Brain Imaging

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For all 164 participants, high-resolution structural T1-weighted volumetric images were acquired at the Centre of Neuroimaging Sciences, Institute of Psychiatry, Psychology, and Neuroscience, London, UK. Images were obtained using a 3-Tesla GE Signa System (General-Electric, Milwaukee, WI) with full-head coverage, 196 contiguous slices (1.1-millimetre (mm) thickness, with 1.09 × 1.09 mm in-plane resolution), a 256 × 256 × 196 matrix, and a repetition time/echo time (TR/TE) of 7/2.8 milliseconds (ms) (flip angle = 20°, FOV = 28 cm). A (birdcage) head coil was used for radiofrequency transmission and reception.

Mann C., Bletsch A., Andrews D., Daly E., Murphy C., Murphy D, & Ecker C. (2018). The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder. Molecular Autism, 9, 49.

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Acquisition of MRI and fMRI Data

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MR images were obtained using a 3.0 Tesla GE Signa system (General Electric, Milwaukee, WI, USA). BOLD functional images were acquired using single-shot gradient-echo echo-planar imaging (EPI) and a standard quadrature head coil (TR/TE = 2000/40 ms, flip angle = 90°, slice gap = 0 mm, FOV = 25.6 cm, in-plane resolution = 128 × 128, 27 axial slices, ascending interleaved sequence, voxel size = 2 × 2 × 4 mm³). Whole brain T1-weighted axial 3D spoiled gradient recalled (SPGR) structural images were acquired using array spatial sensitivity encoding technique (ASSET, i.e., parallel imaging) and an 8-channel head coil (TR/TE = 7.8/3.0 ms, flip angle = 20°, in-plane resolution = 512 × 512, 176 slices, voxel size = 0.5 × 0.5 × 1 mm³).

Tie Y., Rigolo L., Ovalioglu A.O., Olubiyi O., Doolin K.L., Mukundan S J.r, & Golby A.J. (2015). A new paradigm for individual subject language mapping: Movie-watching fMRI. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 25(5), 710-720.

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Bimanual Finger-to-Thumb Movement with Auditory Cues

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The subjects participated in an auditory-cueing bimanual or unimanual finger-to-thumb movement task. Three kinds of movements were elicited by an auditory instruction (move left hand, move right hand, move both hands) in a pseudo-random and balanced sequence and stopped by “stop” instruction. Each movement lasted for 8 s followed by 12 s of rest. The whole experiment lasted for 360 s. During the experiments the subjects were instructed to close their eyes and focus their attention as much as possible. Patients were scanned after their medication had been withdrawn for 4 h.
Data were acquired in a GE Signa System operating at 1.5 T with a gradient echo EPI sequence (TR = 2000 ms, TE = 40 ms, FOV = 24 cm, matrix = 64 × 64 × 24, slice thickness = 5 mm, gap = 1 mm). The 3D structural images were also acquired for each subject with the parameters TR = 12.1 ms, TE = 4.2 ms, FOV = 24 cm, matrix = 256 × 256 × 172, slice thickness = 1.8 mm and gap = 0 mm.

Yan L.R., Wu Y.B., Zeng X.H, & Gao L.C. (2015). Dysfunctional putamen modulation during bimanual finger-to-thumb movement in patients with Parkinson's disease. Frontiers in Human Neuroscience, 9, 516.

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