Pp242 hydrate

Manufactured by Merck Group

Sourced in Germany

PP242 hydrate is a chemical compound used in laboratory research. It functions as a potent and selective inhibitor of the mammalian target of rapamycin (mTOR) kinase. The product is available in a hydrated form.

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Lab products found in correlation

Mefloquine hydrochloride, by Merck Group (1 mentions) Nvp bez235, by Selleck Chemicals (1 mentions) C6628, by Merck Group (1 mentions) A9434, by Merck Group (1 mentions) D8418, by Merck Group (1 mentions) Pi 103, by Selleck Chemicals (1 mentions) Torin1, by Selleck Chemicals (1 mentions) L1825, by Harvard Bioscience (1 mentions) Rapamycin, by Merck Group (1 mentions) Mitomycin, by Merck Group (1 mentions) Ly294002 hydrochloride, by Merck Group (1 mentions) Everolimus, by Merck Group (1 mentions)

Close spelling variants of this product

PP242

2 protocols using pp242 hydrate

Modulation of Autophagy Pathways

Cited 2 times

Check if the same lab product or an alternative is used in the 5 most similar protocols

Mefloquine hydrochloride (Sigma-Aldrich, M2319), Rapamycin (BioAustralis, BIA-R1183), PP242 hydrate (Sigma-Aldrich, P0037) and PI-103, Torin-1, NVP-BEZ-235 (Selleckchem, S1009) were dissolved in DMSO. Drug concentrations were around the doses (mefloquine 10µM and PI-103, Torin-1, NVP-BEZ-235; PP242, 5µM) previously published for analogous in vitro experiments (6 (link), 22 (link)). Established modulators of autophagy were used at a concentration previously reported in similar in vitro experiments: nocodazole, vinblastine (10µM) (23 (link)), PI-103 (5µM), PP242 (5µM), NH₄Cl (10 to 20mM) (Sigma-Aldrich, A9434), and chloroquine (Sigma-Aldrich, C6628) (CQ, 5 to 25µM) (22 (link)–27 (link)). CQ,and NH₄Cl, were dissolved in PBS (Biochrom, L1825), all the remaining reagents were dissolved in DMSO (Sigma-Aldrich, D8418). Z-Val-Ala-DL-Asp-fluoromethylketone (zVAD-fmk) was purchased from Bachem GmbH (Bachem GmbH, Germany) and used as previously described (28 (link)). Cellular viability remained unaffected even by the highest solvent concentration (DMSO 0.1%).

Shah H., Stankov M., Panayotova-Dimitrova D., Yazdi A., Budida R., Klusmann J.H, & Behrens G.M. (2023). Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death. Frontiers in Oncology, 13, 999738.

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Small Molecule Inhibitor Sourcing

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Rapamycin (sirolimus, molar mass 914.172 g/mol), everolimus (molar mass 958.224 g/mol), LY-294002 hydrochloride, PP242 hydrate and mitomycin were purchased from Sigma-Aldrich, Seelze, Germany.

Stöhr S., Costa R., Sandmann L., Westhaus S., Pfaender S., A.n.g.g.a.k.u.s.u.m.a., Dazert E., Meuleman P., Vondran F.W., Manns M.P., Steinmann E., von Hahn T, & Ciesek S. (2015). Host cell mTORC1 is required for HCV RNA replication. Gut, 65(12), 2017-2028.

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