4 octyl itaconate 4 oi

Manufactured by MedChemExpress

Sourced in United States

4-octyl itaconate (4-OI) is a chemical compound. It is a dicarboxylic acid with an eight-carbon alkyl chain attached to one of the carboxyl groups. 4-OI is used as a research chemical for various laboratory applications.

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Lab products found in correlation

Dimethyl sulfoxide (dmso), by Thermo Fisher Scientific (1 mentions) Otx015, by Selleck Chemicals (1 mentions) Arv 825, by Selleck Chemicals (1 mentions) Ruxolitinib, by InvivoGen (1 mentions) Abbv 075, by Selleck Chemicals (1 mentions) Ml385, by Selleck Chemicals (1 mentions) Dimethyl fumarate dmf, by Merck Group (1 mentions) Lipopolysaccharides (lps), by Merck Group (1 mentions) Nk 252, by MedChemExpress (1 mentions)

2 protocols using 4 octyl itaconate 4 oi

Evaluating Epigenetic Modulators in Cell Assays

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(+)-JQ-1 (Cat no. SML1524-5MG) was purchased from Sigma. ABBV-075 (Cat no. S8400) (ClinicalTrails.gov Identifier: NCT02391480), OTX015 (Cat no. S7360) (ClinicalTrails.gov Identifier: OTX015&draw=2&rank=5">NCT02698176), ARV-825 (Cat no. S8297) and ML385 (Cat no. S8790) were purchased from Selleckchem. Dimethyl sulfoxide (DMSO) (Item no. 10127403) was purchased from Thermo Fisher Scientific. 4-octyl itaconate (4-OI) was purchased from MedChemExpress (Cat. no. HY-112675). Dimethyl fumarate (DMF) was purchased from Sigma (Cat. No. 227056). Ruxolitinib was purchased from InvivoGen (Cat. No. tlrl-rux). IFN-α2a (Roferon) was obtained from Roche.

Mhlekude B., Postmus D., Stenzel S., Weiner J 3.r.d., Jansen J., Zapatero-Belinchón F.J., Olmer R., Richter A., Heinze J., Heinemann N., Mühlemann B., Schroeder S., Jones T.C., Müller M.A., Drosten C., Pich A., Thiel V., Martin U., Niemeyer D., Gerold G., Beule D, & Goffinet C. (2023). Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection. PLOS Pathogens, 19(9), e1011657.

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Neuroinflammation Model: Microglia Activation

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A post‐SCI neuroinflammation model in vitro was established using neural debris (1 or 2 mg/mL) to stimulate microglia for 24 h. Depending on the experimental paradigm, microglia were pretreated with Ita (10 mM, MedChemExpress, NJ, USA) or 4‐Octyl Itaconate (4‐OI, 125 μM, MedChemExpress) dissolved in.1% DMSO for 3 h; or the Nrf2 activator NK‐252 (10 μM, MedChemExpress) or Nrf2 inhibitor Nrf2‐IN‐1 (5 μM, MedChemExpress) dissolved in.1% DMSO for 48 h. LPS (1 μg/mL, Sigma–Aldrich, St. Louis, MO, USA) dissolved in PBS was used to treat microglia or 293T cells for a further 24 h.

Qian Z., Xia M., Zhao T., Li Y., Li G., Zhang Y., Li H, & Yang L. (2024). ACOD1, rather than itaconate, facilitates p62‐mediated activation of Nrf2 in microglia post spinal cord contusion. Clinical and Translational Medicine, 14(4), e1661.

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