Cartigram

Manufactured by GE Healthcare

The Cartigram is a lab equipment product by GE Healthcare. It is designed to perform cartilage imaging and analysis. The core function of the Cartigram is to capture and process images of cartilage for diagnostic and research purposes.

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Lab products found in correlation

Sigma excite hdx, by GE Healthcare (1 mentions) Signa excite hdx, by GE Healthcare (1 mentions) Ge discovery mr750, by GE Healthcare (1 mentions)

4 protocols using cartigram

Knee MRI Imaging Protocol for T2 Mapping

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MR images were acquired using a dedicated quadrature transmit and 16-channel receive knee coil array (Invivo Corp) in a 3-Tesla GE Discovery MR750 (GE Healthcare). Two sequences were collected before and after activity. Following a 3-plane localizer scan a commercial sagittal multi-echo spin echo (MESE) sequence (CartiGram; GE Healthcare) was acquired for T₂ mapping [14 (link)] (relaxation time (TR) 2450 ms, 8 echo times (TE) at multiples of 6.312 ms, flip angle 90°, in-plane resolution 0.625 × 0.625 mm, slice thickness 3 mm, slice spacing 1 mm, field-of-view 16 cm, receiver bandwidth, 488.28 Hz/pixel). All echoes were used in the T₂ fit; the CartiGram sequence uses a crusher gradient to reduce the effect of stimulated echoes (GE Healthcare). For segmentation, a 3D fat-saturated T1-weighted sagittal fast spoiled gradient recalled (fSPGR) sequence was acquired (TR 17.388 ms, TE 5.832 ms, flip angle 18º, in-plane resolution 0.3125 × 0.3125 mm, slice thickness 1 mm, slice spacing 0 mm, field-of-view 16 cm, receiver bandwidth 122.07 Hz/pixel). Pre-activity, the fSPGR scan was collected first and the MESE second. Post-activity, the MESE was acquired first. This order of acquisition was used to minimize recovery of T₂ post activity.

Gatti A.A., Keir P.J., Noseworthy M.D, & Maly M.R. (2022). Investigating acute changes in osteoarthritic cartilage by integrating biomechanics and statistical shape models of bone: data from the osteoarthritis initiative. Magma (New York, N.y.), 35(5), 861-873.

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Knee MRI Imaging Protocol for Children

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All subjects underwent an MRI examination of the knee on the same 3-T scanner (Sigma Excite HDx, GE Healthcare) at the American Family Children’s Hospital using an 8-channel phased-array extremity coil (Precision Eight TX/TR High Resolution Knee Array, Invivo). The MRI examination consisted of multiplanar proton density–weighted and T2-weighted fast spin-echo sequences with and without fat suppression and a commercially available T2 mapping sequence (Cartigram, GE Healthcare). The imaging parameters of all sequences are summarized in Table 1.

Nguyen J.C., Allen H., Liu F., Woo K.M., Zhou Z, & Kijowski R. (2018). Maturation-Related Changes in T2 Relaxation Times of Cartilage and Meniscus of the Pediatric Knee Joint at 3 T. AJR. American journal of roentgenology, 211(6), 1369-1375.

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Retrospective Knee MRI Study Protocol

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This retrospective study was performed in compliance with the Health Insurance Portability and Accountability Act regulations, with approval from our institutional review board, and with a waiver of informed consent. MRI data sets were obtained from 175 patients with knee pain (99 men and 76 women, with an average age of 46.5 years and an age range of 16–74 years) who underwent a clinical MRI examination of the knee at our institution between December 15, 2010, and October 15, 2016, using the same 3.0-T MRI unit (Signa Excite HDx; GE Healthcare, Waukesha, Wis) and eight-channel phased-array extremity coil (Invivo, Orlando, Fla). The MRI data sets consisted of sagittal frequency-selective fat-suppressed T2-weighted fast spin-echo, sagittal proton density–weighted fast spin-echo, and sagittal multiecho spin-echo T2 map (Cartigram; GE Healthcare) sequences. The imaging parameters of all sequences are summarized in Table 2.

Liu F., Zhou Z., Samsonov A., Blankenbaker D., Larison W., Kanarek A., Lian K., Kambhampati S, & Kijowski R. (2018). Deep Learning Approach for Evaluating Knee MR Images: Achieving High Diagnostic Performance for Cartilage Lesion Detection. Radiology, 289(1), 160-169.

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Cartilage Assessment via T2 Mapping

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Magnetic resonance imaging was used to assess the cartilage state by T2 mapping using the GE CartiGram as described previously 4 at baseline and 6 and 12 months after treatment. Briefly, mean T2 relaxation values (ms) were sampled in 88 well-defined regions of interest (ROIs) including at the patellar cartilage (24 ROIs), femoral condyles (32 ROIs), and tibial condyles (32 ROIs). We have shown previously that values in healthy individuals distribute normally, with a mean (and median) of 37 ms and a SD of 7 ms. The 95% percentile value was 50 ms. 4 To analyze the assay results, we averaged the values in each area (88 ROIs). Those above 50 ms, which reveal poor-quality remodeling inflammatory tissue, [31] [32] [33] were counted to compute the poor cartilage index (PCI, expressed as a % of all values obtained in the 88 ROIs), as described in the Results. Values above 90 ms were not used for computations. Values at 100% represent the worst possible PCI, and those at 5% or below are considered healthy. The MRI tests were completed in all the 15 control patients and 12 of the 15 test patients.

Vega A., Martín-Ferrero M.A., Del Canto F., Alberca M., García V., Munar A., Orozco L., Soler R., Fuertes J.J., Huguet M., Sánchez A, & García-Sancho J. (2015). Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial. Transplantation, 99(8).

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