N acetylcysteine nac

Manufactured by Abcam

N-acetylcysteine (NAC) is a synthetic derivative of the amino acid cysteine. It acts as a precursor to the antioxidant glutathione and can help maintain cellular glutathione levels. NAC is commonly used in research applications as a reagent.

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Lab products found in correlation

Cell apoptosis detection kit, by MultiSciences Biotech (1 mentions) Z vad fmk, by Selleck Chemicals (1 mentions) Sb203580, by Selleck Chemicals (1 mentions) Anti γh2ax, by Abcam (1 mentions) Cell cycle staining kit, by MultiSciences Biotech (1 mentions) Cck 8 assay kit, by Meilun (1 mentions) Gsk 872, by Merck Group (1 mentions) Gsdmd, by Abcam (1 mentions) Vx 765, by MedChemExpress (1 mentions) Gapdh, by Abcam (1 mentions)

2 protocols using n acetylcysteine nac

Investigating Apoptosis Pathways in Lymphoma

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OCI-LY3 and OCI-LY10 cells were kindly provided by professor Wenbin Qian of Zhejiang University (Zhejiang, China). Z-VAD-FMK and SB203580 were obtained from Selleck Chemicals (Houston, TX). CCK-8 Assay kit was purchased from Meilunbio (Dalian, China). N-acetylcysteine (NAC) and glutathione (GSH) were obtained from Abcam (Cambridge, MA). The Cell Apoptosis detection kit and Cell Cycle Staining Kit were purchased from MultiSciences (Hangzhou, China). Primary antibodies, including anti-cleaved-PARP (ab191217), anti-cleaved-Caspase 3(ab32042), anti-Bax (ab32503), anti-Bad(ab32445), anti-Bcl2(ab32124), anti-β-Actin(ab179467), anti-p21(ab109520), anti-p27(ab32034), anti-p53 (ab179477), anti-p38(ab170099), anti-chk1(ab40866), anti-p-chk2, and anti-γ-H2AX, were purchased from abcam (Cambridge, MA). Antibodies including anti-p-p38(9215S), anti-chk2(3440S), anti-p-chk1(2348P) were purchased from Cell Signaling Technology (Massachusetts, USA). Secondary antibodies, including goat anti-rabbit and goat anti-mouse IgG-HRP were obtained from Beyotome (Shanghai, China).

Yu X., Wang X., Wang X., Zhou Y., Li Y., Wang A., Wang T., An Y., Sun W., Du J., Tong X, & Wang Y. (2020). TEOA Inhibits Proliferation and Induces DNA Damage of Diffuse Large B-Cell Lymphoma Cells Through Activation of the ROS-Dependent p38 MAPK Signaling Pathway. Frontiers in Pharmacology, 11, 554736.

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Molecular Mechanisms of Caspase Activation

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SDG was purchased from MedChemExpress. N‐Acetyl cysteine (NAC) was purchased from Abcam (Abcam), GSK'872 was purchased from Sigma‐Aldrich, the caspase‐1 specific inhibitor VX‐765 and 740Y‐P were purchased from MedChemExpress. Primary antibodies of caspase‐1, caspase‐4, caspase‐5, caspase‐11, GAPDH, and GSDMD were purchased from Abcam (Abcam). Antibodies against BCL2‐associated X (BAX), cytochrome c, phosphorylated‐PI3K (p‐PI3K), phosphorylated‐AKT (p‐AKT), PI3K, and AKT were purchased from Cell Signaling Technology.

Chen T., Wang Z., Zhong J., Zhang L., Zhang H., Zhang D., Xu X., Zhong X., Wang J, & Li H. (2022). Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells. Drug Development Research, 83(5), 1152-1166.

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