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Y3125

Manufactured by Merck Group
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The Merck Group's Y3125 is a laboratory equipment designed for general scientific applications. It functions as a versatile tool for various research and analytical tasks. The product details and intended use are not available in this factual and unbiased response.

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Lab products found in correlation

Yohimbine, by Merck Group (2 mentions) P7791, by Merck Group (2 mentions) A8727, by Merck Group (1 mentions) Wb 4101, by Merck Group (1 mentions) I9278, by Merck Group (1 mentions) Bn0086, by Biotrend (1 mentions) C5776, by Merck Group (1 mentions) P1675, by Merck Group (1 mentions) Noradrenaline, by Merck Group (1 mentions) Lipopolysaccharide lps, by Merck Group (1 mentions) Lipopolysaccharides (lps), by Merck Group (1 mentions) Ici 118 551, by Merck Group (1 mentions) P0884, by Merck Group (1 mentions)

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Yohimbine Y3125 (2 citations)

4 protocols using y3125

1

Anxiogenic and Anxiolytic Effects on Stress

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Anxiogenic (via 5mg/kg α2-adrenoreceptor antagonist yohimbine HCl; Y3125, Sigma-Aldrich, N = 16) and anxiolytic effects (via 20mg/kg CRF1 receptor antagonist antalarmin HCl; A8727, Sigma-Aldrich, N = 10) were administered by intraperitoneal injections (ip, 1.5 ml; vehicle N = 14) 30 minutes prior to SAM exposure on day 3 (Cain et al., 2004 (link); Zorrilla et al., 2002 (link)).
Smith J.P., Prince M.A., Achua J.K., Robertson J.M., Anderson R.T., Ronan P.J, & Summers C.H. (2015). Intensity of anxiety is modified via complex integrative stress circuitries. Psychoneuroendocrinology, 63, 351-361.
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2

Noradrenergic Modulation of Neuronal Activity

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Noradrenaline-bitartrate(10 nM - 100 μM; I9278, Sigma), the α1-AR antagonist prazosine (5 µM; P7791, Sigma), the α2-AR antagonist yohimbine (5 µM; Y3125, Sigma), the α2A-AR antagonist BRL 44408 (10 μM, C5776, Sigma), the α2B-AR antagonist ARC 239, the α1A-AR antagonist WB 4101, the α1C, D-AR antagonist CEC (1 nM – 1 µM, Q102, Sigma) and the α1A-AR agonist A61603 (100 nM; A5861, Sigma) were added to the normal aCSF.
To reduce glutamatergic and GABAergic synaptic input to the recorded neurons, 10 µM CNQX (6-cyano-7-nitroquinoxaline-2,3-dione, C127, Sigma-Aldrich), 50 µM DL-AP5 (DL-2-amino-5-phosphonopentanoic acid, BN0086, Biotrend), and 100 µM PTX (picrotoxin, P1675, Sigma Aldrich) was added to the extracellular saline.
Paeger L., Karakasilioti I., Altmüller J., Frommolt P., Brüning J, & Kloppenburg P. (2017). Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. eLife, 6, e25770.
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3

Adrenergic Receptor Antagonists and LPS-Induced Responses

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Lipopolysaccharide (LPS) was purchased from Sigma-Aldrich (from
E. coli 0111:B4, L2630). The following adrenergic
receptor (AR) antagonists were used: for in vivoexperiment: ICI 118,551 (a selective β2-AR antagonist; 2 mg/kg; 5
mg/ml in stock; I127; Sigma) was injected (i.p.) 30 min before
electroacupuncture stimulation (ES) and Yohimbine (a selective α2-AR
antagonist; 0.5 mg/kg; 1 mg/ml in stock; Y3125; Sigma) was administered
(i.p.) 15 mins before ES, using the doses as reported previously (Archer and Fredriksson, 2000 (link); Vranjkovic et al., 2012 (link)). For
in vitro experiment: noradrenaline (A7257, Sigma) was
dissolved in sterile 0.9% saline chloride and was added to cultured
splenocytes (to the final concentration at 50 μM) 30 mins before or 2
hours after LPS (100 ng/ml) addition. ICI 118,551 or Yohimbine was
administrated at the concentrations indicated in figures 30 mins and 15 mins
prior to noradrenaline addition, respectively.
Liu S., Wang Z., Su Y., Ray R.S., Jing X., Wang Y, & Ma Q. (2020). Somatotopic organization and intensity dependence in driving distinct NPY-expressing sympathetic pathways by electroacupuncture. Neuron, 108(3), 436-450.e7.
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4

Adrenaline and Adrenergic Receptor Antagonists in TBI

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Adrenaline (Tonogen, Richter Gedeon, Hungary), 2 mg/kg, was injected intraperitoneally 5 minutes before CTX injection. Adrenaline‐receptor antagonist prazosin (5 mg/kg, P7791, Sigma), yohimbine (1 mg/kg, Y3125, Sigma) and propranolol (3 mg/kg, P0884, Sigma) were dissolved in sterile saline and injected intraperitoneally 15 minutes before TBI.
Tőkési N., Kozák E., Fülöp K., Dedinszki D., Hegedűs N., Király B., Szigeti K., Ajtay K., Jakus Z., Zaworski J., Letavernier E., Pomozi V, & Váradi A. (2020). Pyrophosphate therapy prevents trauma‐induced calcification in the mouse model of neurogenic heterotopic ossification. Journal of Cellular and Molecular Medicine, 24(20), 11791-11799.
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