Pvalbtm1 cre arbr j

All experimental procedures were conducted according to the UK Animals Scientific Procedures Act (1986). Experiments were performed at University of Sussex under personal and project licenses granted by the Home Office following review by the Animal Welfare and Ethics Review Board.
Experiments were performed on 27 adult transgenic mice of either sex (4–10 months old) expressing the Cre recombinase in specific subsets of interneurons on a C57BL/6J background. Results are reported from nine VIP-Cre mice (VIP tm1(cre)Zjh/J Jackson #010908), eight PV-Cre (Pvalb tm1(cre)Arbr/J, Jackson #008069), and ten SST-Cre (SST tm2.1(cre)Zjh/J, Jackson #013044). Mice were housed individually on inverted light-dark cycles and had access to a complex enriched environment after the end of each imaging session. This environment was large (~80 × 40 × 40 cm) and contained a number of toys, platforms and tubes that encouraged motor activity. As a result, mice were engaged in running the large majority of the time during an imaging experiment.

Mice were 6–12 weeks old at the time of experiments. Mice were acquired from Jackson Laboratories: C57BL/6J; CBA/J; Slc32a1^tm2(cre)Lowl/J (VGAT-Cre); Pvalb^tm1(cre)Arbr/J (PV-Cre); Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/J (Ai9). For Fig. 6, data from our previous studies were reanalyzed (Aponte et al. 2021 (link); Kline et al. 2021 (link); Onodera and Kato 2022 ). For this dataset, additional mice were acquired from Jackson Laboratories (Sst^{tm2.1(cre)Zjh}/J (Sst-Cre)) and MMRRC (Tg(Rbp4-Cre)KL100Gsat/Mmucd (Rbp4-Cre); Tg(Tlx3-Cre)PL56Gsat/Mmucd (Tlx3-Cre)). Both female and male animals were used and housed at 21 °C and 40% humidity with a reverse light cycle (12–12 h). All experiments were performed during their dark cycle. All procedures were approved and conducted in accordance with the Institutional Animal Care and Use Committee at the University of North Carolina at Chapel Hill as well as the guidelines of the National Institutes of Health.

All experiments were approved by the Washington University Animal Care and Use Committee. Heterozygotes (+/–) from two cre-driver mice lines on a C57Bl/6J genetic background were used to label parvalbumin-expressing and somatostatin-expressing inhibitory interneurons: SST^{tm2.1(cre)Zjh}/J (SOM-cre) and Pvalb^tm1(cre)Arbr/J (PV-cre; Jackson Labs). All imaging data were from SOM-ints while behavioral data in Figure 1 were from PV- and SOM-ints.