Ifnγr

Manufactured by Jackson ImmunoResearch

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IFNγR−/− is a laboratory mouse model that has a targeted disruption of the interferon-gamma receptor gene. This model is used in research to study the role of interferon-gamma signaling in various biological processes.

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Lab products found in correlation

Ifn γ, by Jackson ImmunoResearch (5 mentions) C57bl 6, by Jackson ImmunoResearch (3 mentions) C57bl 6j, by Jackson ImmunoResearch (2 mentions) C57bl 6 wt, by Jackson ImmunoResearch (1 mentions) Tnfr1 2, by Jackson ImmunoResearch (1 mentions) Ot 2 mice, by Jackson ImmunoResearch (1 mentions) Cd45.1 c57bl 6, by Jackson ImmunoResearch (1 mentions) Balb c, by Jackson ImmunoResearch (1 mentions)

Spelling variants of this product

IFNγR−/− (B6.129S7Ifngr/J), (3 citations) IFNγR KO (3 citations)

8 protocols using ifnγr

Genetically Modified Mice for IFNγ Study

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Wildtype female C57BL/J, CD45.1, Thy1.1, IFNγ−/−, and IFNγR−/− mice were purchased from Jackson Laboratories (Bar Harbor, ME) and housed in a barrier facility at the University of Iowa. Mice were kept under 12h light/dark cycle, fed ad libitum, humanely cared for and studied as approved by the University of Iowa’s Institutional Animal Care and Use Committee.

Boyden A.W., Brate A.A., Stephens L.M, & Karandikar N.J. (2020). Immune autoregulatory CD8 T cells require IFNγ responsiveness to optimally suppress CNS autoimmunity. Journal of immunology (Baltimore, Md. : 1950), 205(2), 359-368.

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Mouse Models for Immune Research

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C57Bl/6 WT, IFNγ^−/−, IFNγR^−/−, TNFR1/2^−/−, Perforin^−/−, and Fas^−/− mice were obtained from Jackson Laboratories. Vα14-Jα281 transgenic mice were provided by Dr. Albert Bendelac [50] (link). CD1d^−/− mice were provided by Dr. Mark Exley [51] (link). MyD88^−/− mice were provided by Dr. Koichi Kobayashi [52] (link).

Rothchild A.C., Jayaraman P., Nunes-Alves C, & Behar S.M. (2014). iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosis. PLoS Pathogens, 10(1), e1003805.

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Pathogen-free Mouse Breeding and Housing

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C57BL/6J (Stock # 000664) and IFNγR^−/− (Stock # 003288) mice were purchased from the Jackson Laboratory. The Gbp^chr3−/− mice were previously described [29 (link)]. All knockout mice were housed and bred under specific pathogen-free conditions and in accordance with the University of Massachusetts Medical School IACUC guidelines. All animals used for experiments were 6–12 weeks.

Olive A.J., Smith C.M., Baer C.E., Coers J, & Sassetti C.M. (2023). Mycobacterium tuberculosis Evasion of Guanylate Binding Protein-Mediated Host Defense in Mice Requires the ESX1 Secretion System. International Journal of Molecular Sciences, 24(3), 2861.

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Murine Models for Immunological Research

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C57BL/6, CD45.1 C57BL/6, IFNγ−/− (GKO), IFNγR−/−, TCRδ−/− and OT-II mice (all on B6 background) were purchased from The Jackson Laboratory (Bar Harbor, ME). CD45.1 OT-II mice were bred at the Lerner Research Institute animal facility. All mice used were between 6–8 weeks of age. All animal procedures were conducted according to the guidelines of the Institutional Animal Care and Use Committee of the Cleveland Clinic.

Visperas A., Shen B, & Min B. (2014). γδ T cells restrain extrathymic development of Foxp3+ inducible regulatory T cells via IFNγ. European journal of immunology, 44(8), 2448-2456.

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Genetically Modified Mouse Models

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Adult C57Bl/6 (wild type, WT) mice (female, age 8–12 weeks) were purchased from Jackson Laboratory (Bar Harbor, ME) and were housed in micro-isolator cages in the animal facilities at National Jewish Health and Colorado State University. Mice on the C57Bl/6 background lacking a functional IFN-γ gene (IFN-γ^−/−) or IFN-γ receptor gene (IFN-γR^−/−) were purchased from Jackson Laboratory as were mice lacking the CCL2 gene (CCL2^−/−). CCR2-GFP reporter mice (on the C57Bl/6 background) were provided by Dr. Eric Pamer (Memorial Sloan Kettering, NY). Foxp3-GFP reporter mice (C57Bl/6 background) were provided by Dr. A. Rudensky (Washington University, St. Louis, MO).

Takeda K., Webb T.L., Ning F., Shiraishi Y., Regan D.P., Chow L., Smith M.J., Ashino S., Guth A.M., Hopkins S., Gelfand E.W, & Dow S. (2018). Mesenchymal Stem Cells Recruit CCR2+ Monocytes to Suppress Allergic Airway Inflammation. Journal of immunology (Baltimore, Md. : 1950), 200(4), 1261-1269.

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Murine Immune Cell Profiling

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C57BL/6J, TCRδ^−/−, IFN-γ^−/−, IFN-γR^−/−, and TCRα^+/−;TCRδ^EGFP/+ mice were purchased from the Jackson Laboratory. All mice were females, aged 7–8 wk old, and weighed 17–22 g at the time of surgery. Animals were maintained under pathogen-free conditions in the animal facility at Jinan University. All procedures were approved by and performed in accordance with the Jinan University’s Institutional Laboratory Animal Care and Use Committee.

Sun G., Yang S., Cao G., Wang Q., Hao J., Wen Q., Li Z., So K.F., Liu Z., Zhou S., Zhao Y., Yang H., Zhou L, & Yin Z. (2018). γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury. The Journal of Experimental Medicine, 215(2), 521-535.

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Genetically Modified Mouse Models

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Six to ten weeks old male mice were used for all experiments. C57BL/6, 129S6, STAT1^−/−, IFNγ^−/−, IFN-γR^−/−, TNF^−/−, and NOS2^−/− mice were purchased from The Jackson Laboratory (Bar Harbor, ME, USA). Phox^−/−/iNOS^−/− mice and fibrin(ogen)^−/− mice were generously provided by Li Chen (Xinan Hospital, Chongqing). Animals were housed in a specific pathogen-free facility and cared for according to the General Hospital of Chinese People's Liberation Army and Yuhuangding Hospital Animal Care and Use Committee guidelines. Five to ten mice were used for each group in our study.

Wang Z., Zhang D.X, & Zhao Q. (2015). Infection-stimulated Anemia Results Primarily from Interferon Gamma-dependent, Signal Transducer and Activator of Transcription 1-independent Red Cell Loss. Chinese Medical Journal, 128(7), 948-955.

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Murine Fungal and Bacterial Infection Models

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Female mice with an average weight of 20 to 25 g were used throughout these studies. Mice of the A/Jcr, BALB/c, and C57BL/6 and its IFN-γ-R^−/− genetic backgrounds were purchased from the Jackson Laboratories, while mice of the CBA/J genetic background were purchased from Harlan Laboratories. Animal studies were performed at the Public Health Research Institute Animal facility. All studies were conducted by following biosafety level 2 (BSL-2) protocols and procedures approved by the Institutional Animal Care and Use Committee (IACUC) and Institutional Biosafety Committee of Rutgers University.
Cryptococcus neoformans clinical strain H99 and its mutants, as well as C. gattii strain R265 and Candida albicans SC5314, were cultured on yeast extract-peptone-dextrose (YPD) medium. Aspergillus fumigatus strain R21 was kindly provided by David Perlin and cultured on potato-dextrose agar (PDA) medium, and Staphylococcus aureus strain USA400 (MRSA) was cultured on LB medium.

Wang Y., Wang K., Masso-Silva J.A., Rivera A, & Xue C. (2019). A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model. mBio, 10(6), e02145-19.

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