Agi 6780

Manufactured by MedChemExpress

Sourced in United States

AGI-6780 is a small molecule inhibitor. It targets the protein kinase activity of the SYK enzyme.

Automatically generated - may contain errors

Lab products found in correlation

Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Mouse anti c myc, by Santa Cruz Biotechnology (1 mentions) Mouse anti β actin, by Merck Group (1 mentions) Octyl α ketoglutarate octyl α kg, by Cayman Chemical (1 mentions) Rabbit anti lmp1, by Abcam (1 mentions) Bay 1436032, by MedChemExpress (1 mentions) Enasidenib ag 221, by MedChemExpress (1 mentions) Gsk864, by Merck Group (1 mentions)

2 protocols using agi 6780

Investigating Metabolic Regulators in Cells

Cited 2 times

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Dimethyl sulfoxide (DMSO) was obtained from Sigma–Aldrich (Cat: D2650, St. Louis, MO, USA). Octyl-α-ketoglutarate (octyl-α-KG) and octyl-α-hydroxyglutarate (octyl-2-HG) were from Cayman (Cat: 11970 and 16366, Ann Arbor, MI, USA). AGI-6780 and MG132 were purchased from MedChemExpress (Cat: HY-15734 and HY-13259, Monmouth Junction, NJ, USA).
The following antibodies were used: mouse anti-IDH2 (Cat: ab55271, Abcam, Cambridge, MA, USA), mouse anti-β-actin (Cat: A5441, Sigma), rabbit anti-LMP1 (Cat: ab78113, Abcam), rabbit anti-IDH1 (Cat: ab172964, Abcam), and mouse anti-c-Myc (Cat: sc-40, Santa Cruz, Dallas, TX, USA).
The expression vectors for IDH2 and LMP1 have been described previously [7 (link),14 (link)].

Shi F., He Y., Li J., Tang M., Li Y., Xie L., Zhao L., Hu J., Luo X., Zhou M., Liu N., Fan J., Zhou J., Gao Q., Qiu S., Wu W., Zhang X., Jia W., Bode A.M, & Cao Y. (2020). Wild-type IDH2 contributes to Epstein–Barr virus-dependent metabolic alterations and tumorigenesis. Molecular Metabolism, 36, 100966.

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Detailed Compound Characterization Protocol

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Chemicals were used as purchased
and were >95% pure by HPLC according to the commercial suppliers.
Ivosidenib (AG-120), AGI-5198, Agios 135 (HY-12475), Novartis 224
(HY-18717), Novartis 556 (HY-13972), Vorasidenib (AG-881), BAY-1436032,
AGI-6780, and Enasidenib (AG-221) were purchased from MedChem Express.
ML309 hydrochloride, GSK864, and Sanofi 1 (SML1430) were purchased
from Sigma-Aldrich. SYC-435 (TC-E 5008) was purchased from Bio-Techne.

Liu S., Abboud M., Mikhailov V., Liu X., Reinbold R, & Schofield C.J. (2023). Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors. Journal of Medicinal Chemistry, 66(7), 5279-5288.

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