Chloroquine phosphate

Manufactured by Selleck Chemicals

Sourced in United States

Chloroquine phosphate is a laboratory chemical compound used for research purposes. It is a white, crystalline solid that is soluble in water. Chloroquine phosphate is a salt of chloroquine, which is a medication used to treat and prevent malaria. The core function of chloroquine phosphate in a laboratory setting is as a research tool, without further interpretation on its intended use.

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Lab products found in correlation

Rapamycin, by Selleck Chemicals (1 mentions) Zstk474, by Selleck Chemicals (1 mentions) Mk 2206, by Selleck Chemicals (1 mentions) β actin, by Proteintech (1 mentions) Cisplatin, by Selleck Chemicals (1 mentions) Nvp bez235, by Selleck Chemicals (1 mentions) 3 methyladenine, by Selleck Chemicals (1 mentions) Polyethylene glycol 300 peg300, by Merck Group (1 mentions)

2 protocols using chloroquine phosphate

Autophagy Protein Analysis Protocol

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Polyclonal antibody against LC3-I/II (Sigma-Aldrich, St. Louis, MO, USA), antibody against β-actin and SQSTM1 rabbit polyclonal antibody/p62 (both from ProteinTech Group, Inc., Chicago, IL, USA) were used at a dilution of 1:1,000. Monoclonal anti-enterovirus antibody (Dako, Carpinteria, CA, USA) was used at a dilution of 1:100. Goat anti-mouse IgG horseradish peroxidase-conjugated secondary antibody and goat anti-rabbit IgG horseradish peroxidase-conjugated secondary antibody (both from CWBIO, Beijing, China) were used at a dilution of 1:2,000. Rapamycin, ZSTK474, MK2206, and chloroquine phosphate were purchased from Selleck Chemicals (Houston, TX, USA).

Chang H., Li X., Cai Q., Li C., Tian L., Chen J., Xing X., Gan Y., Ouyang W, & Yang Z. (2017). The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells. International Journal of Molecular Medicine, 40(1), 182-192.

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Combinatorial Drug Synergy Evaluation

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NVP-BEZ235 (S1009), cisplatin (S1166), 3-Methyladenine (S2767) and Chloroquine Phosphate (S4157) were obtained from Selleck Chemical in U.S.A. NVP-BEZ235 was provided as a 20 nM stock solution in 100% DMF. Final DMF concentration was kept constant at 0.1% in control and compound-treated cells. cisplatin solution was provided as a 1 mg/ml stock solution in 0.9% isotonic saline solution. 3-Methyladenine solution was provided as a 100 mM stock solution in PBS. Chloroquine Phosphatesolution was provided as a 50 mM stock solution in water. Working solutions were prepared freshly before addition to the cell media.N-Methylpyrrolidine (NMP,120-94-5) and Polyethylene glycol 300 (PEG300,1546423) were bought from Sigma-Aldrich.

Huang J.C., Cui Z.F., Chen S.M., Yang L.J., Lian H.K., Liu B., Su Z.H., Liu J.S., Wang M., Hu Z.B., Ouyang J.Y., Li Q.C, & Lu H. (2017). NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma. Oncotarget, 9(12), 10483-10496.

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