63Zn was produced in a low-energy cyclotron (GE PETtrace, GE HealthCare, Waukesha, WI) via the 63Cu(p, n)63Zn reaction in an in-house-developed solution target, as previously described.12 (link) The final product, 63Zn-zinc citrate was prepared using an isotonic 4% sodium citrate United States Pharmacopeia solution (Fenwal Inc, Lake Zurich, Illinois) and passed standard quality control tests for Current Good Manufacturing Practice for radiopharmaceutical production.12 (link) Specific activity of 63Zn in the radiopharmaceutical product was 19.4 ± 14.6 GBq/μmol at the end of synthesis. Iron and copper ions were present at concentrations of 2.7 ± 2.5 mg/L and 0.18 ± 0.16 mg/L, respectively. Injection volumes ranged from 3 to 7 mL.
Ge pettrace
Manufactured by GE Healthcare
Sourced in Japan, United States
The GE PETtrace is a compact and versatile cyclotron system designed for the production of positron emission tomography (PET) radioisotopes. It is capable of accelerating protons to high energies, enabling the synthesis of a range of PET tracers used in medical imaging applications.
Automatically generated - may contain errors
3 protocols using ge pettrace
1
Production and Formulation of 63Zn-Zinc Citrate
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63Zn was produced in a low-energy cyclotron (GE PETtrace, GE HealthCare, Waukesha, WI) via the 63Cu(p, n)63Zn reaction in an in-house-developed solution target, as previously described.12 (link) The final product, 63Zn-zinc citrate was prepared using an isotonic 4% sodium citrate United States Pharmacopeia solution (Fenwal Inc, Lake Zurich, Illinois) and passed standard quality control tests for Current Good Manufacturing Practice for radiopharmaceutical production.12 (link) Specific activity of 63Zn in the radiopharmaceutical product was 19.4 ± 14.6 GBq/μmol at the end of synthesis. Iron and copper ions were present at concentrations of 2.7 ± 2.5 mg/L and 0.18 ± 0.16 mg/L, respectively. Injection volumes ranged from 3 to 7 mL.
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63Zn was produced in a low-energy cyclotron (GE PETtrace, GE HealthCare, Waukesha, WI) via the 63Cu(p, n)63Zn reaction in an in-house-developed solution target, as previously described.12 (link) The final product, 63Zn-zinc citrate was prepared using an isotonic 4% sodium citrate United States Pharmacopeia solution (Fenwal Inc, Lake Zurich, Illinois) and passed standard quality control tests for Current Good Manufacturing Practice for radiopharmaceutical production.12 (link) Specific activity of 63Zn in the radiopharmaceutical product was 19.4 ± 14.6 GBq/μmol at the end of synthesis. Iron and copper ions were present at concentrations of 2.7 ± 2.5 mg/L and 0.18 ± 0.16 mg/L, respectively. Injection volumes ranged from 3 to 7 mL.
2
Production and Purification of [18F]Fluoride
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No-carrier-added aqueous [18F]fluoride was produced via the 18O(p,n)18F nuclear reaction through the bombardment of enriched [18O]H2O with 17 MeV protons in a BC1710 cyclotron (The Japan Steel Works, Tokyo, Japan) or a GE PETtrace (GE Healthcare, Chicago, IL, USA), both at the INM-5 (Forschungszentrum Jülich). Radioactivity was measured using a CRC-55tR Dose Calibrator from Capintec, Inc. (Florham Park, The Netherlands) and/or a Curiementor 2 (PTW, Freiburg, Germany). QMA carbonate light plus cartridges (130 mg, Waters GmbH, Eschborn, Germany) were preconditioned with 2 mL H2O. SepPak C18 light cartridges (130 mg, Waters GmbH, Eschborn, Germany) were preconditioned with 5 mL EtOH followed by 5 mL H2O.
3
11C-Methionine PET Brain Imaging Protocol
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The L-[methyl-11C] methionine radiotracer was synthesized utilizing an on-site cyclotron (GE PETtrace; GE Healthcare, Chicago, IL, USA). To ensure stable baseline metabolic conditions, all patients underwent a 4 h fasting period before scanning. Subsequently, patients received injections ranging from 370 to 555 MBq of 11C-methionine on the scan day.
To minimize potential confounding effects, patients were instructed to limit physical activity, followed by a 10 min rest period post-injection. Approximately 10 min after injection, low-dose transmission CT images were acquired to facilitate brain attenuation correction for the PET emission data and provide morphological information.
Whole-brain emission data were acquired in three-dimensional mode, 15–20 min post-injection of 11C-MET, utilizing a Philips Vereos Digital PET/CT scanner (Philips Healthcare, Amsterdam, the Netherlands). This comprehensive imaging protocol ensured optimal visualization and quantification of metabolic activity within the brain tissue.
To minimize potential confounding effects, patients were instructed to limit physical activity, followed by a 10 min rest period post-injection. Approximately 10 min after injection, low-dose transmission CT images were acquired to facilitate brain attenuation correction for the PET emission data and provide morphological information.
Whole-brain emission data were acquired in three-dimensional mode, 15–20 min post-injection of 11C-MET, utilizing a Philips Vereos Digital PET/CT scanner (Philips Healthcare, Amsterdam, the Netherlands). This comprehensive imaging protocol ensured optimal visualization and quantification of metabolic activity within the brain tissue.
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