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Dimethyl sulfoxide (dmso)

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DMSO (Dimethyl Sulfoxide) is a colorless, odorless, and polar aprotic solvent. It has a high boiling point and low toxicity, making it a versatile solvent for a wide range of applications in the laboratory setting. DMSO is commonly used as a cryoprotectant and carrier for various biological compounds, as well as a solvent for chemical reactions and extractions.

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Lab products found in correlation

Hank s balanced salt solution, by Thermo Fisher Scientific (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Decanoic acid, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Bio-Techne (1 mentions) A922500, by Merck Group (1 mentions) Diacylglycerol, by Avanti Polar Lipids (1 mentions)

2 protocols using dimethyl sulfoxide (dmso)

1

Tracking Fatty Acid Metabolism with Alkyne Probes

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Fatty acids: FA 11:0;Y (10-undecynoic acid, TCI Deutschland GmbH), FA 17:0;Y (16-heptadecynoic acid, alkyne-palmitate [47 (link)], FA 19:1;Y (nonadec-9-cis-en-18-ynoic acid, previously named alkyne-oleate [47 (link)] and FA 10:0 (decanoic acid, Merck) were used for labelling experiments as stock solutions (14–20 mM in 80% EtOH). Small molecule inhibitors: etomoxir (Eto), 30 mM in ddH2O from Cayman Chemical; A922500 (DGAT1 inhibitor (D1i)), 10 mM in DMSO (Sigma–Aldrich); JNJ-DGAT2A (DGAT2 inhibitor (D2i)), 10 mM in DMSO (Tocris); Teglicar (Tegli), 10 mM in DMSO (Avanti Polar Lipids). Twenty four-well plates and 100-μm cell strainer were purchased from Sarstedt AG. Willliams medium E was purchased from PAN Biotech. All other cell culture reagents (FCS, 200 mM of glutamine stock and 10,000 U of penicillin-streptomycin solution, Hank's Balanced Salt Solution) were purchased from Invitrogen or Sigma–Aldrich.
Wunderling K., Leopold C., Jamitzky I., Yaghmour M., Zink F., Kratky D, & Thiele C. (2020). Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir. Molecular Metabolism, 45, 101150.
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2

Lipid Standards for Biological Research

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Diacylglycerol (DG; DG[18:0-20:4]; 1-stearoyl-2-arachidonoyl-sn-glycerol; 800818C-10 mg; referred to as 38:4), DG(18:0-22:6; 1-stearoyl-2-docosahexaenoyl-sn-glycerol; 800819C-10 mg; referred to as 40:6), and LPA(18:0; 1-stearoyl-2-hydroxy-sn-glycero-3-phosphate [sodium salt]; 857128P-25 mg) were bought from Avanti Polar Lipids and dissolved in DMSO (dimethyl sulfoxide; Alabama).
Dzobo K.E., Cupido A.J., Mol B.M., Stiekema L.C., Versloot M., Winkelmeijer M., Peter J., Pennekamp A.M., Havik S.R., Vaz F.M., van Weeghel M., Prange K.H., Levels J.H., de Winther M.P., Tsimikas S., Groen A.K., Stroes E.S., de Kleijn D.P, & Kroon J. (2024). Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(3), 720-740.
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