Luna c18 10μ 10 250mm

All common solvent and reagents were obtained by commercial sources. NMR spectra were recorded on Bruker Avance III 700 MHz and these were used both for quality control and to verify the concentration of the stock solutions used for dose response measurements and in vivo studies. An Agilent LC-TOF instrument was used to obtain high-resolution mass spectral data. Purification of all agents was obtained using RP-HPLC on a JASCO preparative system equipped with a PDA detector. The instrument is also equipped with a fraction collector controlled by a ChromNAV system (JASCO). For all agents, a Luna C18 10μ 10 × 250mm (Phenomenex) column was used to purify agents to > 95% purity. For intermediate reagents that were not commercially available, RP-chromatography purification was performed using a CombiFlash (Teledyne ISCO). GM6001 was obtained from Enzo Life science. MMP408 was obtained from EMD Millipore Corp.

Common reagents and routine solvents were obtained by commercial sources. NMR spectra were recorded on Bruker Avance III 700 MHz equipped with a TCI cryoprobe. ¹H NMR measurements in assay buffer were used for quality control and to routinely verify the concentration of the stock solutions used for all studies. Purification of the peptides was obtained using a reverse phase HPLC preparative system (JASCO) equipped with a PDA detector and a fraction collector controlled by a ChromNAV system (JASCO). For all the peptides reported, a Luna C18 10μ 10 × 250mm (Phenomenex) column was used to purify agents to > 95% purity. An Agilent LC-TOF instrument was used to obtain the high-resolution mass spectral data as reported in supplementary Table S2.