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Male sprague dawley rats

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Male Sprague-Dawley rats are a commonly used laboratory animal model. They are a strain of albino rats developed at the Sprague-Dawley Animal Company. These rats are widely utilized in various research and testing applications.

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Lab products found in correlation

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Close spelling variants of this product

Sprague-Dawley rats (506 citations) Adult male Sprague-Dawley rats (42 citations) Sprague-Dawley (8 citations) Male Holtzman and Sprague Dawley rats (2 citations) Male Sprague‐Dawley ex‐breeder rats (2 citations) Male Sprague Dawley outbred rats (2 citations)

202 protocols using male sprague dawley rats

1

Acclimation of Male Sprague-Dawley Rats

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Male Sprague-Dawley rats (N = 10) were obtained from Envigo at 7 to 8 weeks of age. TEK-Fresh® (Envigo, Indianapolis, IN) bedding was used in polycarbonate home cages (48.3 × 26.7 × 20.3 cm [l × w × h]) where each rat was housed individually. Upon arrival, rats were handled daily for one week to acclimate them to the colony and personnel. Before the start of the study, food was restricted to maintain weights at 85% free-feed body weight (average ad lib feed weight = 291 g). This weight was increased by 2 g each month. The colony room was temperature- and humidity-controlled with lights on a 12-hour light/dark schedule (lights on at 6 AM). All protocols were approved by the University of Nebraska-Lincoln Institutional Animal Care and Use Committee.
Thompson B.M., Tracy M.E., Huynh Y.W., Dwoskin L.P., Barrett S.T, & Bevins R.A. (2022). Varenicline serves as the training stimulus in the drug discriminated goal-tracking task with rats: Initial evaluation of potential neuropharmacological processes. Behavioural pharmacology, 34(1), 12-19.
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2

Sprague Dawley Rats for Experimental Research

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Male Sprague Dawley rats (200–250 g, 5–7-week-old; Envigo, Milan, Italy) were used in this research. Rats were housed in individual cages (five per cage) and maintained under a 12:12 h light/dark cycle at 21 ± 1 °C and 50 ± 5% humidity. A standard laboratory diet and tap water were available ad libitum. This study was approved by the University of Messina Review Board for the care of animals. Animal care conformed to Italian regulations on the use of animals for experimental and scientific purposes (D.Lgs 2014/26 and EU Directive 2010/63).
D’Amico R., Cordaro M., Siracusa R., Impellizzeri D., Trovato Salinaro A., Scuto M., Ontario M.L., Crea R., Cuzzocrea S., Di Paola R., Fusco R, & Calabrese V. (2021). Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox®. Biomedicines, 9(11), 1683.
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3

Housing and Feeding of Sprague-Dawley Rats

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Male Sprague-Dawley rats (n = 16) (Envigo, Livermore, CA) weighing between 275 and 300 g upon arrival were housed in a temperature (20–22° C) and humidity (45–55%)-controlled facility with artificial lighting (12-h/12-h reverse light-dark cycle, lights off at 10:00AM). Rats were pair-housed in tub cages with a plastic divider separating the rats with ad libitum access to powdered Purina Rat chow 5001 and water, unless noted otherwise. All animal procedures met the guidelines of the National Institutes of Health and were approved by The Scripps Research Institute Institutional Animal Care and Use Committee.
Rupprecht L.E., Kreisler A.D., Spierling S.R., de Guglielmo G., Kallupi M., George O., Donny E.C., Zorrilla E.P, & Sved A.F. (2018). Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology, 235(4), 1131-1140.
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4

Circadian Rhythm Study in Rats

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Additional methodological details are described in the supplemental methods. Subjects 155 Male Sprague-Dawley rats (60 days old; 275-300 g at arrival; Envigo, Indianapolis, IN) were housed individually in a temperature-and humidity-controlled AAALAC-accredited animal facility on a 12:12 h reverse light/dark cycle (0700-1900 lights off) with ad libitum food and water access. Procedures were conducted in the dark/active phase of the rat light cycle. Procedures were approved by the Institutional Animal Care and Use Committee at Marquette University and conducted in compliance with NIH Guidelines.
McReynolds J.R., Wolf C.P., Starck D.M., Mathy J.C., Schaps R., Krause L.A., Hillard C.J, & Mantsch J.R. (2023). Role of mesolimbic cannabinoid receptor 1 in stress-driven increases in cocaine self-administration in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 48(8).
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5

Influences of Age, Housing, and Context on Rats

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Male Sprague Dawley rats (Envigo Inc, Haslett, MI) arrived at post-natal day 25, P25 (60–80 gm, n=51), or P56 (260–280 gm, n=32) and were pair housed upon arrival with ad libitum access to food and water. Humidity and temperature were regulated within the vivarium and rats were maintained on reverse lighting conditions (7 am off, 7 pm on) with all behavioral conditions occurring during the rats’ active cycle. Rats underwent habituation and handling for 7–8 days prior to surgery. Following surgical procedures, rodents were separated into two housing groups (pair vs single) and maintained on 15 gm (adolescent) or 18 gm (adult) of chow, which were adjusted to allow for normal growth (Carroll ME 1985 (link); DePoy et al. 2016 (link); Cho et al. 2018 (link)). Female rats were not included in the current study to focus on Age x Context × Housing factors. All protocols were approved by the Institutional Animal Care and Use Committee (IACUC) at Michigan State University (MSU) and followed the National Research Council’s Guide for the Care and Use of Laboratory Rats.
Cho B.R., Gerena J., Olekanma D.I., Bal A., Charpentier A.N, & Arguello A.A. (2020). Role of adolescent-formed, context-drug-associations on reinstatement of drug-seeking behavior in rats.1. Psychopharmacology, 237(9), 2823-2833.
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6

Sprague-Dawley Rat Housing Protocol

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Male Sprague–Dawley rats (Envigo, Chicago, IL; 240–300 g) were housed in groups of three on a 12 h light/dark cycle with free access to water and food. Protocols for animal experiments in this study were performed in accordance with the guidelines of the National Institute of Health and approved by the Animal Care and Use Committee at Rosalind Franklin University of Medicine and Science.
Martinon D., Lis P., Roman A.N., Tornesi P., Applebey S.V., Buechner G., Olivera V, & Dabrowska J. (2019). Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear. Translational Psychiatry, 9, 140.
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7

Sprague Dawley Rat Housing and Care

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Male Sprague Dawley rats (Envigo, Indianapolis, IN, USA) weighing 300–400g and between ages of postnatal day 80–90 were individually housed in wire-hanging cages in a climate controlled (22–24°C) environment with a 12 hr: 12hr light/dark cycle. Animals were maintained on a diet of ad libitum access to standard rat chow (LabDiet 5001, LabDiet, St. Louis, MO), except where noted. Experiments were performed in accordance with NIH Guidelines for the Care and Use of Laboratory Animals, and all procedures were approved by the local committee of the Institute of Animal Care and Use (University of Southern California).
Noble E.E., Hahn J.D., Konanur V.R., Hsu T.M., Page S.J., Cortella A.M., Liu C.M., Song M.Y., Suarez A.N., Szujewski C.C., Rider D., Clarke J.E., Darvas M., Appleyard S.M, & Kanoski S.E. (2018). Control of feeding behavior by cerebral ventricular volume transmission of melanin-concentrating hormone. Cell metabolism, 28(1), 55-68.e7.
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8

Sprague-Dawley Rat and Swiss Albino Mouse Study

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Male Sprague-Dawley rats (Envigo, Varese, Italy) weighing approximately 200-250 g and male Swiss albino mice (Envigo, Varese, Italy) weighing approximately 23-25 g at the beginning of the experimental procedure were used. Animals were housed in CeSAL (Centro Stabulazione Animali da Laboratorio, University of Florence) and used at least 1 week after their arrival. Four rats and five mice were housed per cage (size 26-41 cm); animals were fed with standard laboratory diet and tap water ad libitum, and kept at 23
Tenci B., Di Cesare Mannelli L., Maresca M., Micheli L., Pieraccini G., Mulinacci N, & Ghelardini C. (2017). Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats. Zeitschrift fur Naturforschung. C, Journal of biosciences, 72(11-12).
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9

Sprague-Dawley Rat Model Study

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All animal use procedures were in strict accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals. The experimental protocol was approved by Virginia Commonwealth University’s Institutional Animal Care and Use Committee and by the Animal Care and Use Review Office of the U.S. Army Medical Research and Material Command. Male Sprague-Dawley rats (Envigo, Indianapolis, Indiana) weighing approximately 300 g and 9 weeks of age were used in this study. Animals were housed 2 per cage at 20°C–22°C with a 12-h light-dark cycle (lights on 06:00–18:00 h) and given free access to food and water.
Phillips K.F., Santos E., Blair R.E, & Deshpande L.S. (2019). Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness. Toxicological Sciences, 169(2), 567-578.
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10

Traumatic Brain Injury in Juvenile Rats

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Male Sprague Dawley rats (Envigo, Indianapolis, IN) were used for all experiments. Rats were housed in a 12 h light: 12 h dark cycle at a constant temperature (23°C ± 2°C) with food and water available ad libitum according to the Association for Assessment and Accreditation of Laboratory Animal Care International guidelines. All rats were acclimated from shipping a minimum of one week prior to experiments. PND17 rats were shipped with the dam. After surgery, post-operative care via physical examination took place to monitor each animal's condition. PND17 rats were returned to their dam following surgery and midline fluid percussion injury (mFPI) until tissue collection (2H, 24H, 7D), or until they were weaned at PND24. Average PND17 pre-surgical weight was 28.2 ± 3.2 g. Average PND35 pre-surgical weight was 135.5 ± 14.3 g. Weights and health conditions were monitored and documented throughout the experiment. Animal care and experiments were approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Arizona (protocol 13–460).
Green T.R., Murphy S.M., Ortiz J.B, & Rowe R.K. (2022). Age-At-Injury Influences the Glial Response to Traumatic Brain Injury in the Cortex of Male Juvenile Rats. Frontiers in Neurology, 12, 804139.
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