Discovery qdr series

Manufactured by Hologic

Sourced in United States

The Discovery QDR Series is a line of dual-energy X-ray absorptiometry (DXA) equipment designed for bone density and body composition analysis. The system utilizes advanced X-ray technology to provide accurate and precise measurements of bone mineral density and soft tissue composition.

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Lab products found in correlation

Whole body dxa reference database software, by Hologic (4 mentions) Visceral fat software, by Hologic (2 mentions) Discovery wi, by Hologic (1 mentions) Takei 5401, by Takei Scientific Instruments (1 mentions) Rat step phantom p n 010 0758, by Hologic (1 mentions) Hem 907, by Omron (1 mentions) Electronic scale, by Tanita (1 mentions)

33 protocols using discovery qdr series

Sarcopenia Diagnosis and Treatment Protocol

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The diagnosis of sarcopenia was based on Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment [6 (link)].
Muscle mass was measured by dual-energy x-ray absorptiometry (DXA) Hologic scanner (Hologic Discovery QDR Series, Bedford, MA, USA), and ASMI (ratio of appendicular muscle mass to squared height) less than 7.0 kg/m² in male or 5.4 kg/m² in female was defined as low muscle mass.
Hand grip strength was assessed with digital dynamometer (CAMRY EH10, Xiangshan, Guangdong), and HGS less than 28 kg in male or 18 kg in female was defined as low muscle strength.
Physical performance was evaluated by 6-m gait speed test and five chair stand test. It was 6-m gait speed test time more than 6 s (low gait speed) or FCST time no less than 12 s (low FCST) that was defined as low physical performance.

Ge J., Zeng J., Li N., Ma H., Zhao Z., Sun S., Jing Y., Qian C., Fei Z., Qu S., Cui R, & Sheng H. (2022). Soluble interleukin 2 receptor is risk for sarcopenia in Men with high fracture risk. Journal of Orthopaedic Translation, 38, 213-219.

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Evaluating Body Composition and Bone Density

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Dual-energy X-ray absorptiometry (DEXA; Hologic Discovery QDR Series; Hologic Inc., Bedford, MA) was used to evaluate bone mineral density, lean mass, and fat mass. The lean mass was defined as skeletal muscle mass, and appendicular muscle mass was defined as the combined lean mass of both arms and legs. Appendicular skeletal muscle mass index (ASMI), appendicular fat mass index (AFMI), and appendicular bone mineral density (ABMD) were calculated as each measurement divided by height in meters squared. Grip strength was measured using a Smedley-type handgrip dynamometer.

Fujiki S., Watanabe H., Obata H., Suda M., Mitsuma W., Tomii A., Sakai K., Uehara A., Shimizu I., Kashimura T., Ozaki K, & Minamino T. (2021). Adipokines in patients with heart failure under rehabilitation. Acta Bio Medica : Atenei Parmensis, 92(3), e2021195.

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Objective Measurement of Physical Activity and Fitness in Children

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Physical activity was measured using pedometers (Walk 4 Life, Plainfield, IL, USA) over seven consecutive days. As previously suggested [21 ], daily step counts less than 1000 and greater than 30,000 were considered erroneous and discarded. In order to maximise data, all valid days of pedometer data were used in the analyses and incomplete data were adjusted, taking into account between child variation, sex, and day of the week differences using a Best Linear Unbiased Predictor as previously described [22 (link)]. This effectively removes the inherent skewness of the absolute number of steps per day by scaling PA with the square root. Cardio-respiratory fitness (CRF) was measured using the 20m multistage run, a well-established field test for children [23 (link)]. In each data collection phase, the same technician conducted both the fitness and PA measures. Body composition was measured using dual emission x-ray absorptiometry (DEXA, Hologic Discovery QDR Series, Hologic Inc., Bedford, MA, USA) and Hologic Software Version 12.4:7 was used to calculate percent body fat. Height (portable stadiometer to the nearest 0.001m), weight (portable electronic scales to the nearest 0.05 kg) and BMI (kg/m²) were measured in participants without shoes and wearing light clothing using standard measures.

Telford R.M., Telford R.D., Olive L.S., Cochrane T, & Davey R. (2016). Why Are Girls Less Physically Active than Boys? Findings from the LOOK Longitudinal Study. PLoS ONE, 11(3), e0150041.

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Body Composition and Cardiorespiratory Fitness Assessments

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Body weight was measured with a calibrated digital scale (to the nearest 0.1 kg; Tanita® PH‐740) and waist circumference (in centimeters) was measured at the level of the superior iliac crest at months 0, 3, 6, 9, 12, 15, 18, and at a 24‐month follow‐up. Body composition (percent fat mass) was measured using the dual‐energy x‐ray absorptiometry (Hologic Discovery QDR series; Hologic) at months 0, 6, 12, and 18. Cardiorespiratory fitness was measured with a maximal aerobic capacity test (VO₂max) at months 0, 6, 12, and 18 using a modified Balke treadmill protocol¹⁴ and indirect calorimetry (Parvo Medic Truemax 2400).

Ostendorf D.M., Blankenship J.M., Grau L., Arbet J., Mitchell N.S., Creasy S.A., Caldwell A.E., Melanson E.L., Phelan S., Bessesen D.H, & Catenacci V.A. (2021). Predictors of long‐term weight loss trajectories during a behavioral weight loss intervention: An exploratory analysis. Obesity Science & Practice, 7(5), 569-582.

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Body Composition Assessment by DEXA

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The medical history of all patients were reviewed. Anthropometric measurements, including height, weight, WC, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were obtained from all participants. BMI was calculated as weight in kilograms divided by the square of height in meters. Body composition was measured with a DEXA scanner (Hologic Discovery QDR Series; Hologic, Bedford, MA) by a trained technician. All standard procedures were performed as previously described for previous studies (20, 21) : each subject was reclined in a supine position and was scanned from head to foot in the standard mode. The scanning range width was fixed at 60 cm, and the scanning time was $20 min. The Hologic Whole Body DXA Reference Database Software and Hologic Visceral Fat Software were used to estimate the TBF percentage and SAT and VAT volume.

Chen X., Mao Y., Hu J., Han S., Gong L., Luo T., Yang S., Qing H., Wang Y., Du Z., Mei M., Zheng L., Lv X., Tang Y., Zhao Q., Zhou Y., He J.C., Li Q, & Wang Z. (2021). Perirenal Fat Thickness Is Significantly Associated With the Risk for Development of Chronic Kidney Disease in Patients With Diabetes. Diabetes, 70(10).

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Osteoporosis Diagnosis Criteria Protocol

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A patient was diagnosed with osteoporosis if she fulfilled the WHO criteria for osteoporosis (a T-score of ≤ -2.5SD at the total hip, femoral neck, or lumbar spine) or if she had at least one vertebral fracture and a loss of height of more than 25% on radiography or of more than 40% on VFA, according to Genant's classification [27] (link). Criteria for osteopenia were a T-score between -1.0 and -2.5SD at the lumbar spine and/or hip and no morphometric abnormalities (Hologic DXA equipment, Hologic Discovery QDR Series).

van den Berg P., van Haard P.M.M., van der Veer E., Geusens P.P., van den Bergh J.P, & Schweitzer D.H. (2018). A dedicated Fracture Liaison Service telephone program and use of bone turnover markers for evaluating 1-year persistence with oral bisphosphonates. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 29(4).

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Rodent Bone Density Measurement

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Using rodent’s calibration feature, excised legs were scanned with DEXA (Hologic, Discovery QDR Series, Bedford, MA, USA) to obtain BMC, BMD, fat mass, lean mass, and total mass [53 (link)].

Goodarzi P., Wileman C.M., Habibi M., Walsh K., Sutton J., Shili C.N., Chai J., Zhao J, & Pezeshki A. (2022). Effect of Isoleucine and Added Valine on Performance, Nutrients Digestibility and Gut Microbiota Composition of Pigs Fed with Very Low Protein Diets. International Journal of Molecular Sciences, 23(23), 14886.

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Body Composition Assessment Protocol

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Body weight and body composition were measured with a calibrated digital scale (to the nearest 0.2 lbs.). WC (cm) was measured just over the iliac crests using a tape measure. FM and LM were measured with the dual-energy X-ray absorptiometry (DXA, Hologic Discovery QDR Series, Bedford, MA).

Caldwell A.E., Zaman A., Ostendorf D.M., Pan Z., Swanson B.B., Phelan S., Wyatt H.R., Bessesen D.H., Melanson E.L, & Catenacci V.A. (2020). Impact of Combined Hormonal Contraceptive Use on Weight Loss: A Secondary Analysis of a Behavioral Weight Loss Trial. Obesity (Silver Spring, Md.), 28(6), 1040-1049.

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Anthropometric and Body Composition Measures

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Weight (SECA 760) and height (SECA 220) was measured following standard procedures by the same trained investigator in each study center. Thereafter, BMI and sex- and age-specific BMI z-scores according to the World Health Organization reference standards were calculated. Bone mineral content (BMC, in g), (BMD, in g/cm²), body fat percent, and lean mass (LM, in kg) were assessed by Dual-Energy X-Ray Absorptiometry (DXA) using the HOLOGIC Discovery QDR SERIES in ActiveBrains and the HOLOGIC QDR 4500W in EFIGRO.

Muñoz-Hernandez V., Arenaza L., Gracia-Marco L., Medrano M., Merchan Ramirez E., D. Martinez Avila W., Oses M., R. Ruiz J., B. Ortega F, & Labayen I. (2018). Influence of Physical Activity on Bone Mineral Content and Density in Overweight and Obese Children with Low Adherence to the Mediterranean Dietary Pattern. Nutrients, 10(8), 1075.

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DXA Scan for Sarcopenia Diagnosis

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Body composition was measured using a DXA Hologic scanner (Hologic Discovery QDR^Ⓡ Series, Bedford, MA, USA) by a trained technician, including the fat and muscle mass in the head, limbs, trunk, and internal organs. All standard procedures were carried out as previously described in the literature. The Hologic Whole Body DXA reference database software was used to estimate the regional and whole-body lean tissue. The diagnostic criteria for sarcopenia were based on the Baumgartner diagnostic criteria: appendicular lean mass index (ALMI)=appendicular lean mass (ALM=Arm LM + Leg LM) / height2 in kg/m2. The diagnostic criteria of sarcopenia were ALMI < 7.01kg/m2 and < 5.42kg/m2 in males and females, respectively (17 (link)).

Yang Q., Ni X., Zhang Y., Zhu B., Zeng Q., Yang C., Shi J., Zhang C., Cai J., Hu J., Li Q., Jiang Y., Cheng Q, & Cheng C. (2023). Sarcopenia is an independent risk factor for all-cause mortality rate in patients with diabetic foot ulcers. Frontiers in Nutrition, 10, 1097008.

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