Acclaim c18 5 μm 120 column

All solvents and reagents were purchased from commercial suppliers (TCI America, Alfa Aesar, AK Scientific, Sigma-Aldrich, Fisher Scientific, Fluka) and were used as received. Deionized water was filtered through the PURELAB Ultra Mk2 system. ¹H, ¹³C{¹H}, ¹H-¹³C{¹H} HSQC and COSY NMR spectra were recorded at ambient temperature on Bruker AV400 instruments, as specified; the NMR spectra are expressed on the δ scale and were referenced to residual solvent peaks. Low-resolution (LR) mass spectrometry was performed using a Waters ZG spectrometer with an ESCI electrospray/chemical-ionization source, and high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS) was performed on a Micromass LCT time-of-flight instrument at the Department of Chemistry, University of British Columbia. Analyses of radiolabeled compounds were performed with both thin layer chromatography (TLC) (i.e. silica aluminum-backed TLC plates and iTLC-impregnated with silica gel (iTLC-SG) strips) purchased from Agilent Technologies. The radio-TLC scanner model was the Cyclone Storage Phosphor System (Cyclone Plus) from Perkin Elmer and the HPLC system was Dionex Ultimate 3000. DIONEX Acclaim C18 5 μm 120 Å column (250 mm × 4.60 mm) was used for separation of free radioactivity and radio-complex. ⁴⁴Sc and ⁸⁶Y were provided by the UW-Madison Cyclotron Lab as 0.1 M HCl solutions.

All solvents and reagents were purchased from commercial suppliers (TCI
America, Alfa Aesar, AK Scientific, Sigma-Aldrich, Fisher Scientific, Fluka) and
were used as received. ¹H, ¹³C,
¹H−¹³C HSQC,
¹H−¹³C HMBC, COSY, and NOESY NMR spectra were
recorded at ambient and elevated temperature on Bruker AV400 instruments, as
specified; the NMR spectra are expressed on the δ scale
and were referenced to residual solvent peaks. Low-resolution (LR) mass
spectrometry was performed using a Waters ZG spectrometer with an ESCI
electrospray/chemical-ionization source, and high-resolution
electrospray-ionization mass spectrometry (HR-ESI-MS) was performed on a
Micromass LCT time-of-flight instrument at the Department of Chemistry,
University of British Columbia. Analyses of radiolabeled compounds were
performed with both iTLC-silicic acid impregnated plates (iTLC-SA) purchased
from Agilent Technologies and radio-HPLC. The TLC scanner model was a BIOSCAN
(system 200 imaging scanner), and the HPLC system was from Agilent Technologies
(1200 series). A DIONEX Acclaim C18 5 μm 120 Å
column (250 mm × 4.60 mm) was used for separation of free radioactivity
and the radio-complex. ⁴⁴Sc was provided by the UW—Madison
Cyclotron Lab in 0.1 M HCl solution (~259 MBq). Deionized water was
filtered through the PURELAB Ultra Mk2 system.