Trihydrochloride

Manufactured by Merck Group

Trihydrochloride is a chemical compound that serves as a reagent in laboratory settings. It is used to conduct various scientific experiments and analyses. The core function of Trihydrochloride is to facilitate specific chemical reactions and processes required for research and testing purposes.

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Lab products found in correlation

Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Formaldehyde, by Merck Group (1 mentions) Heparin, by Merck Group (1 mentions) Histamine, by Merck Group (1 mentions) λ carrageenan, by Merck Group (1 mentions) Morphine, by Merck Group (1 mentions) Compound 48 80, by Merck Group (1 mentions) Acetic acid, by Merck Group (1 mentions) Ml141, by Merck Group (1 mentions) Gf109203x, by Merck Group (1 mentions) Cdc42, by Merck Group (1 mentions) Ipa 3, by Merck Group (1 mentions)

Spelling variants of this product

BisBenzimide H 33342 trihydrochloride (31 citations) Spermidine trihydrochloride (30 citations) Bisbenzimide H 33342 trihydrochloride (Hoechst 33342) (8 citations) NSC23766 trihydrochloride (6 citations) Hoechst (bisBenzimide H33342 Trihydrochloride, (5 citations) Bisbenzimide trihydrochloride (Hoechst 33258) (4 citations) Hoechst 33342 (bisBenzimide H33342 trihydrochloride; (4 citations) BisBenzimide Hoechst 33342 trihydrochloride (3 citations) Spermidine trihydrochloride (SPD, (3 citations) Arg-Arg β-naphthylamide trihydrochloride (2 citations)

2 protocols using trihydrochloride

Carrageenan-Induced Inflammation Study

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Chemicals,
reagents, and drugs
used throughout this study were obtained from commercial sources and
used as received. We purchased λ-carrageenan, prostaglandin
E2 (PGE2), dextran, histamine, compound 48/80 (4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine, trihydrochloride (C₃₂H₄₅N₃O₃·3HCl)), dimethylsulfoxide
(DMSO), acetic acid, and formaldehyde from Sigma-Aldrich (St Louis,
MO). Morphine, naloxene, and heparin were acquired from Merck (São
Paulo, SP, Brazil). All drugs were dissolved in sterile saline solution
(0.9%), except AA, which was solubilized in 5% DMSO, and subsequently
diluted in 0.9% NaCl (Vehicle). AA was extracted, isolated, and identified
as described by Gomes Júnior and co-workers.^{66 (link)}

Gomes Júnior A.L., Islam M.T., Nicolau L.A., de Souza L.K., Araújo T.D., Lopes de Oliveira G.A., de Melo Nogueira K., da Silva Lopes L., Medeiros J.V., Mubarak M.S, & Melo-Cavalcante A.A. (2020). Anti-Inflammatory, Antinociceptive, and Antioxidant Properties of Anacardic Acid in Experimental Models. ACS Omega, 5(31), 19506-19515.

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Inhibitors of Macropinocytosis and Protein Kinase

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We used several inhibitors for macropinocytosis and protein kinase. The following were added into the culture medium 1 h before IgG stimulation: trihydrochloride as a Rac1 inhibitor (Sigma Aldrich, St, Luis, MO, 200 μM in H 2 O), dihydrochloride as a Rho-associated coiled-coil forming protein kinase (ROCK) inhibitor (Sigma Aldrich, St Luis, MO, 10 μM in H 2 O), ML141 as a Cdc42 inhibitor (Sigma Aldrich, St Luis, MO, 10 μM in DMSO), IPA-3 as a p21-activated kinase 1 (PAK1) inhibitor (Sigma Aldrich, St Luis, MO, 25 μM in DMSO), and GF109203X as a PKC inhibitor (Sigma Aldrich, St, Luis, MO, 5 μM in DMSO).

Iwata H., Kamaguchi M., Ujiie H., Nishimura M., Izumi K., Natsuga K., Shinkuma S., Nishie W, & Shimizu H. (2016). Macropinocytosis of type XVII collagen induced by bullous pemphigoid IgG is regulated via protein kinase C. Laboratory investigation; a journal of technical methods and pathology, 96(12).

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