Spss statistics for mac ver 26

Statistical analysis was performed with SPSS Statistics for Mac Ver. 26 (SPSS Inc., Chicago, IL). Patients were divided into three groups (<6, 6–12, and >12 years old) according to previous literature (Döring et al., 2017 (link); Lavigne et al., 2019 (link)). Descriptive statistics included the mean, standard deviation, and median. The categorical variables were expressed as frequency and percentage. Categorical variables were compared using χ² test or Fisher’s exact test. Continuous variables were compared using Mann-Whitney U-test or Kruskal-Wallis H test. The correlation between two continuous variables was examined using the Spearman correlation coefficient. The association of C_min with efficacy and safety was analyzed by logistic regression. Affecting factors of PCZ trough concentrations were analyzed using multivariate analysis by linear regression. p values < 0.05 were considered statistically significant.

Descriptive statistics included the mean, standard deviation, and median. The categorical variables were expressed as frequency and percentage. Baseline demographics and plasma PCZ concentrations differences between groups were analyzed by using the chisquare test, ManneWhitney U test, or KruskaleWallis test, as appropriate. The association of C_min with efficacy and safety was analyzed by logistic regression to obtain the target PCZ trough plasma concentration range. The logistic regression model was calculated according to equation (1), the P_i value reflected the probability of PCZ related response in the individual and was calculated as equation (2). θ₁ is the baseline probability of response; θ₂ is the logarithm of the contribution ratio of drug exposure; λ_i is the logit value, the natural logarithm of odds ratio.
Considering the large variations in PCZ daily doses, we further normalized the PCZ concentrations to dose and investigated their correlation with various potential risk factors. Both univariate and multivariate linear regression analyses were used to identify the relationship between dose normalized PCZ concentration and potential factors. Data analysis was performed with SPSS Statistics for Mac Ver. 26 (SPSS Inc., Chicago, IL). GraphPad Software (GraphPad Prism 7.0) was used for mapping. Values of P < 0.05 were considered statistically significant.