Before the procedure, the New Zealand rabbits were anesthetized via intramuscular injection. The animals were placed in a supine position with the neck hyperextended under fluoroscopic guidance (Artis zee DSA system, SIEMENS, Germany). The whole process was completed through a 5-Fr stent delivery system. A 12-Fr dilator (12-F dilator, Cook Medical) was used to dilate the entrance. Then, an intratracheal channel was created with a 0.035-inch guidewire (Terumo Corporation, Tokyo, Japan) and 5-Fr catheter (Terumo Corporation, Tokyo, Japan). The delivery system was pushed with the stent over the guidewire, and the stent was released at least 1.5–2 cm cranially to the carina (as shown in Fig. 6 a). The animals were then clinically monitored and sacrificed 4 weeks after stenting.
5 fr catheter
Manufactured by Terumo
Sourced in Japan
The 5-Fr catheter is a medical device used for various diagnostic and therapeutic procedures. It is a flexible tube with a diameter of 5 French (approximately 1.67 millimeters) designed for insertion into blood vessels or other body cavities. The core function of the 5-Fr catheter is to provide a conduit for the introduction or withdrawal of fluids, medications, or other medical instruments during medical procedures.
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4 protocols using 5 fr catheter
1
Tracheal Stenting in Rabbit Model
2
Transarterial Chemoembolization for Liver Tumors
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TACE was performed by senior hepatologists with at least 5 years of experience in interventional techniques. The procedure was commenced by introducing a 5-Fr catheter (Terumo, Tokyo, Japan) via the femoral artery punctured using the Seldinger technique. Superior mesenteric, celiac angiography, and indirect portovenography were performed to localize the tumors and assess the portal blood flow. Using a coaxial catheter technique, a 2.6-Fr microcatheter (Terumo, Japan) was superselectively advanced to the tumor feeding arteries. A chemotherapeutic agent was administered as slowly as possible by injecting a mixture of 20-60 mg doxorubicin and 2-12.5 mL lipiodol (Lipiodol Ultra-Fluid; Laboratoire Andre Guerbet, Aulnay-sous-Bois, France) into the feeder vessels. Polyvinyl alcohol particles of 300 μm diameter (gelatin sponge particles; Cook, IN, USA) mixed with contrast material were slowly injected into the target arteries until arterial flow was static or stasis was approximated. After embolization, hepatic angiography was repeated to assess the extent of vascular occlusion. If the feeding artery was not completely embolized, gelatin sponge particle embolism was repeated.
3
Hepatic Artery Infusion Chemotherapy Protocol
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Digital subtraction angiography (DSA) was used for all procedures. An artery sheath catheter was inserted into the femoral artery by using a modi ed Seldinger technique. After that, the feeding hepatic artery was assessed by inserting a 5-Fr catheter (Terumo) into both the celiac trunk and the superior mesenteric artery. A micro-catheter (Terumo; 2.7-Fr) was inserted into the feeding artery. Additionally, the chemo-drugs were administered via the microcatheter in the HAI. A modi ed FOLFOX6 regimen involving leucovorin (dose, 200 mg/m 2 within 2 h on Day one), oxaliplatin (dose, 85 mg/m 2 within 2 h on Day one), and uorouracil (dose, 400 mg/m 2 in bolus, and then a continuous infusion of 2,400 mg/m 2 within 46 h) was administered. We removed the sheath and the catheter when HAIC was completed. Treatment repetitions were generally performed every 21 days for four to six cycles, unless cases were intolerant of intrahepatic lesion progression or toxicity.
4
Transarterial Chemoembolization for Liver Tumors
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In this study, an associate professor with 15 years of interventional technology experience performed all TACE operations. TACE was performed on the celiac and common hepatic arteries, which were catheterized using a 5Fr catheter (Terumo, Tokyo, Japan) into the femoral artery by the Seldinger's method, and digital subtraction angiography was performed using a nonionic iodine contrast agent. After evaluating the tumor-located segment by cone-beam CT, super-selective intubation of segmental or sub-segment target arteries was performed using a 0.035 mm ultra-slip microcatheter (Terumo, Tokyo, Japan) and verified by DSA inspection. Next, the ultra-slip microcatheter was advanced toward the tumor-feeding artery. Then, chemotherapeutic drugs and embolic agents were manually injected into a tumor-feeding artery, depending on the size and number of tumors, blood supply, and hepatic function of the patient. Pirarubicin or Lobaplatin (50 mg/m 2 ) and absorbable gelatin sponge particles (Nanjing, China) were prepared by mixing 5-10 ml lipiodol (Guerbet, France).
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