Pravastatin

Manufactured by Daiichi Sankyo

Sourced in Thailand, Japan

Pravastatin is a laboratory product manufactured by Daiichi Sankyo. It is a lipid-lowering agent used in research and development. The core function of Pravastatin is to inhibit the enzyme HMG-CoA reductase, which plays a key role in the production of cholesterol in the body.

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Lab products found in correlation

Bp 2000, by Visitech (3 mentions) Ang 2, by Fujifilm (1 mentions) Atorvastatin, by Pfizer (1 mentions) Alzet osmotic pump, by Durect (1 mentions)

2 protocols using pravastatin

Evaluating the Effects of Pravastatin and Phytosterols on Cholesterol Levels

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pravastatin was taken after dinner once daily and phytosterols were taken in the form of a cereal beverage in the morning once daily. Tablets of 40 mg of pravastatin for the study were purchased from Daiichi Sankyo, EUROPE GmbH. The phytosterol product for the study was Hearti Benecol^® which contained 2 g of plant stanols per pack and was purchased directly from Sahapattanavibool Co., LTD., Thailand. A multivitamin preparation was the placebo for pravastatin with Nestvita^® (Nestle Thailand) which minimized an excess of calories from Hearti Benecol^® (Table 1). The nutritional facts of both products were provided by the manufacturers.Table 1

Nutritional facts of phytosterol-enriched cereal beverage and standard cereal beverage

	Hearti Benecol^®	Nestvita^®
Total calories (kcal/1pack)	110	100
Total fat (g)	4	2
Total protein (g)	2	4
Total carbohydrate (g)	17	17
Fiber	1	4
Sugar	3	10
Total plant stanols	2.0	0
Plant stanol ester	1.15

Kietsiriroje N, & Leelawattana R. (2015). Effects of pravastatin, phytosterols, and combination therapy on lipid profile in HIV-infected patients: an open-labelled, randomized cross-over study. BMC Research Notes, 8, 294.

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Evaluating Cardiac Hypertrophy and Fibrosis in SmgGDS Mice

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We used 10-week-old male SmgGDS hetero-deficient (SmgGDS +/-) mice to evaluate cardiac hypertrophy and fibrosis as previously reported because SmgGDS -/-mice are embryo-lethal. 11, (link)19 Age-and sex-matched wild-type (WT) littermate mice were used as controls. Mice were subcutaneously and continuously infused with Ang II (2.0 mg/kg per day; WAKO, Tokyo, Japan) or saline for 2 weeks by Alzet osmotic pumps (model 2002, Durect Corporation, CA), and they were orally administered either atorvastatin (10 mg/kg per day, Pfizer), pravastatin (50 mg/kg per day, Daiichi Sankyo, Tokyo, Japan), or placebo for 2 weeks. 11 (link) Systolic blood pressure was measured using a noninvasive tail-cuff system (BP-2000, Visitech Systems, Inc, NC) before and 2 weeks after pump implantation without anesthesia.

Kudo S., Satoh K., Nogi M., Suzuki K., Sunamura S., Omura J., Kikuchi N., Kurosawa R., Satoh T., Minami T., Ikeda S., Miyata S, & Shimokawa H. (2016). SmgGDS as a Crucial Mediator of the Inhibitory Effects of Statins on Cardiac Hypertrophy and Fibrosis: Novel Mechanism of the Pleiotropic Effects of Statins. Hypertension (Dallas, Tex. : 1979), 67(5).

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