Ge signa scanner 3 t

Our analysis was conducted on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset publicly available at (adni.loni.usc.edu). The initiative was launched in 2003 as a public-private partnership, led by Principal Investigator Michael W. Weiner, MD (see www.adni-info.org for updates). To match the aim of our study, we combined two types of ADNI datasets:

DWI volumes was taken at two-time points, at the baseline and after 12 months (we refer to this as follow-up). In this set, we used a cohort comprised of 31 Alzheimer’s disease patients (age: 76.5 ± 7.4 years), and 49 healthy elderly subjects (77.0 ± 5.1) matched by age, as well as 57 MCI subjects (age: 75.34 ± 5.93).

The PLINK binary files (BED/BIM/FAM) genotypic data for AD, controls and Early MCI.

The DWI and T1-weighted were obtained by using a GE Signa scanner 3 T (General Electric, Milwaukee, WI, USA). The T1-weighted scans were acquired with voxel size =  $1.2\times 1.0\times 1.0$
mm³ TR = 6.984 ms; TE = 2.848 ms; flip angle = 11°). DWI were acquired at voxel size =  $1.4\times 1.4\times 2.7$
mm³, scan time = 9 min, and 46 volumes (5 T2-weighted images with no diffusion sensitization b0 and 41 diffusion-weighted images b = 1000 s/mm²).

For the imaging, we obtained the DWI volumes at two time points, the baseline and follow-up visits, with 1 year in between. Along with the DWI, we used the T1-weighted images which were acquired using a GE Signa scanner 3T (General Electric, Milwaukee, WI, USA). The T1-weighted scans were obtained with voxel size = 1.2 × 1.0 × 1.0mm³TR = 6.984ms; TE = 2.848 ms; flip angle = 11°, while DWI was obtained with voxel size = 1.4 × 1.4 × 2.7mm³, scan time = 9 min, and 46 volumes (5 T2-weighted images with no diffusion sensitization b0 and 41 diffusion-weighted images b = 1000s/mm²).