Oxytetracycline

Citric acid (CA), uric acid (UA), europium nitrate hexahydrate (Eu(NO₃)₃·6H₂O), nicotinic acid, glucose, D-alanine, L-glutamic acid, L-cysteine and L-leucine were purchased from Aladdin Chemistry Co., Ltd. (Shanghai, China). Antibiotics including oxytetracycline, tetracycline, chlortetracycline, doxycycline, metacycline, minocycline, penicillin, azithromycin, streptomycin, ciprofloxacin and norfloxacin were purchased from Shanghai Macklin Biochemical Co., Ltd. (Shanghai, China). All common metal salts were purchased from Sinopharm Chemical Regents Co., Ltd. (Shanghai, China). HEPES buffer (200 mM) with different pH values was prepared by titrating 200 mM HEPES aqueous solution with 3 M NaOH standard solution. Deionized water (18.2 MΩ cm) prepared from the UPHW-I-90T ultrapure water system was used to prepare standard solutions throughout the experiments. Apparatus and characterization are described in the Supplementary Materials.

2-aminoterephthalic acid (ATA, 98%), tetracycline (TET, ≥98%), doxycycline (DOX, ≥98%), oxytetracycline (OTC, ≥98%), chlortetracycline (CTC, ≥98%), chloramphenicol (CAP, 98%), tyrosine (Tyr), histidine (His), serine (Ser), phenylalanine (Phe), arginine (Arg) and cysteine (Cys) were provided by Shanghai Macklin Biochemical Co., Ltd. (Shanghai, China). Zirconium chloride (ZrCl₄, 99%) was purchased from Beijing Yinuokai Technology Co., Ltd. (Beijing, China). Methacrylic acid (MAA, 99%), 2,2-azobisisobutyronitrile (AIBN, 99%) and ethylene glycol dimethacrylate (EGDMA, 98%) were obtained from TCI Development Co., Ltd. (Shanghai, China). N, N-dimethylformamide (DMF), ethanol, glucose, sucrose, MnCl₂·4H₂O, MgCl₂·6H₂O, Zn(NO₃)₂·6H₂O, CaCl₂, NaCl and KCl were supplied by Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China). All reagents and chemicals used in this work were of at least analytical grade. The apparatuses utilized in this study are described in detail in the supporting information.