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Nvp adw742

Manufactured by Selleck Chemicals
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NVP-ADW742 is a laboratory equipment product manufactured by Selleck Chemicals. It is a specialized device designed for use in scientific research and experimentation. The core function of NVP-ADW742 is to perform specific analytical tasks within a controlled laboratory environment. This product is intended for use by trained professionals in the field of scientific research and development.

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Lab products found in correlation

Recombinant human igf 1, by Thermo Fisher Scientific (2 mentions) Gsk1838705a, by Selleck Chemicals (1 mentions) Osi 906, by Selleck Chemicals (1 mentions) Dimethyl sulfoxide (dmso), by Nacalai Tesque (1 mentions) Pq401, by Bio-Techne (1 mentions) Osi 906, by LKT Laboratories (1 mentions) Az3146, by Adooq (1 mentions) Ro 3306, by Selleck Chemicals (1 mentions) Cyt 386, by ProSpec (1 mentions) Pd166866, by Selleck Chemicals (1 mentions)

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ADW742 (2 citations)

4 protocols using nvp adw742

1

Evaluation of IGF1R Inhibitors and Doxorubicin

Cited 2 times
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The IGF1R inhibitors OSI-906, NVP-ADW742 and GSK1838705A were purchased from Selleck Chemicals LCC (see Additional file 1: Table S1 for properties) and dissolved in DMSO in a concentration of 10 mM. The IGF1R inhibitors were tested in concentrations up to 1 μM as it was demonstrated previously that higher concentrations lead to an aspecific toxic response [24 (link)]. Recombinant human IGF1 (PeproTech) was used in a concentration of 50 ng/ml [25 (link)]. Doxorubicin was obtained from the in-house hospital pharmacy in a 0.9 % NaCl solution, and used in a concentration range of 1–100 nM.
Peterse E.F., Cleven A.H., De Jong Y., Briaire-de Bruijn I., Fletcher J.A., Danen E.H., Cleton-Jansen A.M, & Bovée J.V. (2016). No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone. BMC Cancer, 16, 475.
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2

Cell Cycle Regulation by Kinase Inhibitors

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The IGF-1R inhibitors PQ401 (2768, Tocris Bioscience, Ellisville, MO, USA), OSI-906 (07333, LKT Laboratories, St. Paul, MN, USA), NVP-ADW742 (S1088, Selleck Chemicals, Houston, TX, USA), the Aurora B inhibitor ZM447439 (JS Research Chemicals Trading, Wedel, Germany), the PLK1 inhibitor BI12536 (A10134, AdooQ Bioscience, Irvine, CA, USA), and the MPS1 inhibitor AZ3146 (A11170, AdooQ Bioscience) were used. For cell-cycle synchronization to M phase, the reversible CDK1 inhibitor RO-3306 (S7747, Selleck Chemicals) was used. These inhibitors were dissolved in DMSO (Nacalai Tesque, Kyoto, Japan). Recombinant human IGF1 was purchased from Peprotech (100-11, London, UK).
Yamagishi A., Ikeda Y., Ikeuchi M., Yuki R., Saito Y, & Nakayama Y. (2020). Targeting Insulin-Like Growth Factor 1 Receptor Delays M-Phase Progression and Synergizes with Aurora B Inhibition to Suppress Cell Proliferation. International Journal of Molecular Sciences, 21(3), 1058.
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3

Steroid Hormone and Growth Factor Signaling

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Chemicals were obtained from Sigma Aldrich (St. Louis, MO) unless otherwise stated. l7, 20β-dihydroxy-4-pregnen-3-one (DHP) was purchased from Steraloids (Newport, RI) and R5020 (promegestone) from Amersham Pharmacia Biotech (Piscataway, NJ). The selective mPRα agonists, l0-ethenyl-l9-norprogesterone (Org OD 02–0) and l9α-methylprogesterone (Org OD l3–0) (Kelder et al., 20l0) were obtained from N.V. Organon (Oss, The Netherlands). The nuclear progesterone antagonist, RU486 (mifepristone), was purchased from MedChem Express (Monmouth Junction, NJ). [l, 2, 6, 7 3H] l7β-Hydroxyprogesterone (85 Ci/mmol) were purchased from Amersham Pharmacia Biotech and converted to [3H]-l7, 20β-dihydroxy-4-pregnen-3-one ([3H]-DHP) enzymatically as described previously (Scott et al., l982). The ErbB2 inhibitor II (4-(3-phenoxyphenyl)-5-cyano-2H-l, 2, 3-triazole) was purchased from Calicochem (Billerica, MA). PTX was purchased from List Biological Laboratories (Campbell, CA). The IGF-l receptor inhibitor, NVP-ADW742 was purchased from Selleck Chemicals (Houston, TX). Human insulin-like growth factor-l receptor (IGF-lR) (middle region) antibody (Product No. AVARp00004_P050) was purchased from Aviva Systems Biology Corp.
Aizen J., Pang Y., Harris C., Converse A., Zhu Y., Aguirre M.A, & Thomas P. (2018). Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation. General and comparative endocrinology, 263, 51-61.
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4

Evaluating Small Molecule Inhibitors

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Mouse FGF2 is a recombinant protein purchased from Prospec (CYT-386). Fresh powder for confirmation was ordered from the NCI’s DTP or from Caymen Chemical. Picropodophyllin and fluvastatin were obtained from the DTP (Fig. 2). Fluvastatin (10010337), simvastatin (MK-733), rosuvastatin (ZD 4522), pravastatin (10010342), atorvastatin (10493), cycloheximide (14126), and mitomycin C (11435) were ordered from Caymen Chemical. PD166866 (S8493) and NVP-ADW742 (S1088) was purchased from SelleckChem. eBioscience™ Cell Proliferation Dye eFluor™ 450 (65-0842-85) and SYTOX™ Red Dead Cell Stain, for 633 or 635 nm (S34859) were purchased from ThermoFisher. I-BET-762 was purchased from JSTAR Research Inc.
Benham V., Bullard B., Dexheimer T.S., Bernard M.P., Neubig R.R., Liby K.T, & Bernard J.J. (2019). Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay. Scientific Reports, 9, 10278.
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